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The map label for this gene is fumC [H]

Identifier: 229587014

GI number: 229587014

Start: 947545

End: 948936

Strand: Direct

Name: fumC [H]

Synonym: RAF_ORF0917

Alternate gene names: 229587014

Gene position: 947545-948936 (Clockwise)

Preceding gene: 229587013

Following gene: 229587015

Centisome position: 74.11

GC content: 36.71

Gene sequence:

>1392_bases
ATGAAAAATTACAGAACCGAAAGTGATTCTTTTGGAGAAATTCAAATAGAAGAAAAATTTTATTGGGGGGCTCAAACTCA
AAGATCTTTAGAAAATTTTAAAATAGGCAAGCAAAAAATGCCTGAAATTTTAATTCGTGCTCTTGCTATTTTAAAAAAAT
GTGCAGCACAGGTTAATCATGAGTTTGGTGATTTAGAAGCTAAAATCGCTATAAGTATAGATAAAGCCACGGATAGAATC
TTAGAAGGCGAATTTGAGGATAATTTTCCTTTAGTAGTTTGGCAAACAGGTTCAGGAACGCAAACAAACATGAATATGAA
CGAGGTTATTGCCTCTATTGCCAACGAAGAATTAACAGGCAAGAAAGGCGGCAAATCTCCGGTACATCCTAACGATCATG
TTAATAAAGGACAATCATCCAACGACTCTTTTCCAACCGCTATGCATATAGCAACCGTACTTGCAACTAAACAGCAACTG
ATACCAGCTTTGAATAATATACTGACCTCTTTGCAGGATAAGTCAAAAGATTGGGACAAAATCATAAAAATAGGACGTAC
CCACTTGCAGGATGCAACTCCTTTAACTCTTAAACAGGAATTCTCCGGATATATTACACAAATAGAGTATGCTTTAGAAC
GCATAGAAAATGCACTACAAAAAGTTTATCTACTGGCCCAAGGAGGCACAGCAGTCGGTACAGGTATTAACTCAAAAATA
GGCTTTGATATAAAATTTGCCGAGAAAGTGGCAGAGTTTACTAAACAACCCTTTAAGACGGCTCCTAATAAATTTGAAAG
TCTAGCTGCTCACGACGCACTAGTAGAATTTTCAGGAACTCTTAATACTATAGCAGTTAGCTTAATGAAAATAGCAAATG
ATATAAGACTGCTCGGCTCCGGTCCAAGATGCGGTCTTGGTGAGCTACATTTACCTGAAAATGAACCTGGTTCTTCTATT
ATGCCCGGTAAAGTAAACCCTACACAAGTCGAAGCTTTAACAATGGTGTGCAGTCAGGTGATGGGGAATCATGTTACGGT
TACTATTGCCGGCTCAAACGGACATCTTGAACTTAACGTATTTAAACCCGTAATAATATACAATATCCTACAATCTATAG
AGCTGTTATCCGATAGCGTAAATAGCTTTGTTACTCACTGTGTTAAAGGATTAGAACCCAATATAGCACGCATTAATGAT
TTACGTGATAAATCTCTAATGCTTGTTACAGCTCTTAATCCGCATATAGGCTATGATAATGCTGCAAAAATTGCTAAAGA
AGCACATAAGCACGGGATCACTTTAAAAGAAGCAGCTAAAAAACTCAATCTTCTATCGGAAGCAAAATTTGATAAAATAG
TAGTACCTGAAAAAATGGTTAGTCAATCTTAG

Upstream 100 bases:

>100_bases
TATATTATAGCTTTGCTAAATTAGCCCAGCAATTAGACTTGAATGCAGTAAGTGATCATTTTATGAAAAAAATAGATAAT
TATATAACATTTAACAATTT

Downstream 100 bases:

>100_bases
GTTTGATACAAAGATATTAATTTAAACTATTAATATTACTGTATAAAATCTTATAAATAGGATAATATTAAATTAGTCTA
TTATTATATTACCTATGTGA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNHEFGDLEAKIAISIDKATDRI
LEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTGKKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQL
IPALNNILTSLQDKSKDWDKIIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIENALQKVYLLAQGGTAVGTGINSKI
GFDIKFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIANDIRLLGSGPRCGLGELHLPENEPGSSI
MPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNVFKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARIND
LRDKSLMLVTALNPHIGYDNAAKIAKEAHKHGITLKEAAKKLNLLSEAKFDKIVVPEKMVSQS

Sequences:

>Translated_463_residues
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNHEFGDLEAKIAISIDKATDRI
LEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTGKKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQL
IPALNNILTSLQDKSKDWDKIIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIENALQKVYLLAQGGTAVGTGINSKI
GFDIKFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIANDIRLLGSGPRCGLGELHLPENEPGSSI
MPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNVFKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARIND
LRDKSLMLVTALNPHIGYDNAAKIAKEAHKHGITLKEAAKKLNLLSEAKFDKIVVPEKMVSQS
>Mature_463_residues
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNHEFGDLEAKIAISIDKATDRI
LEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTGKKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQL
IPALNNILTSLQDKSKDWDKIIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIENALQKVYLLAQGGTAVGTGINSKI
GFDIKFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIANDIRLLGSGPRCGLGELHLPENEPGSSI
MPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNVFKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARIND
LRDKSLMLVTALNPHIGYDNAAKIAKEAHKHGITLKEAAKKLNLLSEAKFDKIVVPEKMVSQS

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=62.8260869565217, Blast_Score=580, Evalue=1e-166,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=57.1428571428571, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=58.4782608695652, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI87082375, Length=454, Percent_Identity=37.6651982378855, Blast_Score=301, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=60.8225108225108, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI32565146, Length=323, Percent_Identity=63.7770897832817, Blast_Score=428, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=61.304347826087, Blast_Score=581, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=61.4718614718615, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=61.4718614718615, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=58.351409978308, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=58.1896551724138, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=51.9480519480519, Blast_Score=481, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50840; Mature: 50840

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNH
CCCCCCCCCCCCEEEEECEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
EFGDLEAKIAISIDKATDRILEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTG
CCCCCEEEEEEEEEHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
KKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQLIPALNNILTSLQDKSKDWDK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIENALQKVYLLAQGGTAVGTGINSKI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCCCCCCC
GFDIKFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIANDIRLLGS
CCCHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECC
GPRCGLGELHLPENEPGSSIMPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEE
FKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARINDLRDKSLMLVTALNPHIGYDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCCCH
AAKIAKEAHKHGITLKEAAKKLNLLSEAKFDKIVVPEKMVSQS
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEECCHHHHCCC
>Mature Secondary Structure
MKNYRTESDSFGEIQIEEKFYWGAQTQRSLENFKIGKQKMPEILIRALAILKKCAAQVNH
CCCCCCCCCCCCEEEEECEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
EFGDLEAKIAISIDKATDRILEGEFEDNFPLVVWQTGSGTQTNMNMNEVIASIANEELTG
CCCCCEEEEEEEEEHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
KKGGKSPVHPNDHVNKGQSSNDSFPTAMHIATVLATKQQLIPALNNILTSLQDKSKDWDK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
IIKIGRTHLQDATPLTLKQEFSGYITQIEYALERIENALQKVYLLAQGGTAVGTGINSKI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCCCCCCC
GFDIKFAEKVAEFTKQPFKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIANDIRLLGS
CCCHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECC
GPRCGLGELHLPENEPGSSIMPGKVNPTQVEALTMVCSQVMGNHVTVTIAGSNGHLELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEE
FKPVIIYNILQSIELLSDSVNSFVTHCVKGLEPNIARINDLRDKSLMLVTALNPHIGYDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCCCH
AAKIAKEAHKHGITLKEAAKKLNLLSEAKFDKIVVPEKMVSQS
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEECCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA