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The map label for this gene is lon1 [H]

Identifier: 229586735

GI number: 229586735

Start: 613441

End: 615777

Strand: Direct

Name: lon1 [H]

Synonym: RAF_ORF0584

Alternate gene names: 229586735

Gene position: 613441-615777 (Clockwise)

Preceding gene: 229586733

Following gene: 229586736

Centisome position: 47.98

GC content: 34.92

Gene sequence:

>2337_bases
ATGCATAAAAAATCCCTTCCGTTAATGGCACTGAGAGATATGGTAGTATTCCCGGGAGTAATTGCGCCTATTTTTGTGGG
TAGGCCAAAATCGTTGCAAGCACTCTCTAATACTACCATTTTCGAGGAAGATAATAGTAAATACATTTTAGTAACTTTAC
AGAAAAAATTTGATCAAGAAAACCCTAGTACACACGAACTTTATAATACAGCTATACTTGCCAAGATTATCCAAATAGTG
AAGCTGCCTAATAATACGGCAAAAATCTTAATAGAAGCAGTAGCAAGAGTAAAGCTAAGCAATATCAAAGGCGAGGAAGC
TTTTGAAGCAAATTATGAAATTATTCCAGATGAAGAAATATTTGACGTTAATAACATGCGTTCACTCGTTGATAATGCAG
TACAACTATTTAGTAAATATGCGATTAATGATAAGAAAGTTAATGCAGAAATTATTGAAACTATCAATAAAAAAATAAGT
AATAGCACTAATTTCATAGATATTATAAATATATTAGCCTCACATTTGATAACTTCACTTGAGGCAAAGCAGCATTTATT
AGAAGAAACGAGTCCTTTTAAGCGTATCACTACGGTTATTAGTATGCTTACTTCCAATATAGTAAATTCAGAAACCGAGC
AGGCATTGCAGCAAAGAGTACGAAAGCAAATCGAAAAAACGCAGCGTGATTATTATCTGCACGAACAAATGAAAGCTATT
CAAAAAGAGCTTGATGAAGATAAATCAGAACTTGCCGATATTGAGAAAAAAATTAAAAGTTTAAAATTATCAAAAGAAGC
AAAAGAAAAAGCTGAGGCTGAACTTAAGAAACTCCGTACTATGAACCAAATGTCAGCGGAGTCGGGAGTAACGCGTAACT
ATCTTGAGACATTGCTTAGCCTGCCTTGGGGTAAGTATGATAATAGCAAAATAGATATTAACCAAGCAGAGAAAATTTTA
AATCGTGACCATTTTGGACTCGAAAAAGTTAAAGAACGAATTATAGAATATTTAGCGGTATTACAGCGTTCAAGTAAAAT
TAGAGGACCTATATTATGTTTAATAGGTCCGCCAGGGGTCGGTAAAACTTCACTTGTAAAATCTATTGCCGAAGGAATGG
GCAGAAAATATACTAAACTTGCGCTCGGCGGTGTTAGAGACGAAGCAGAAATCAGAGGGCATAGAAAAACTTACCTTGGA
TCAATGCCCGGTAAAATTTTAGGTCAACTTAAGAAAGTTAAGACTAGTAATCCTGTAATGCTGCTTGATGAAATCGATAA
AATGAGTTCTGATTTTAGAGGTGATCCGGCATCCGCTTTGCTTGAGGTATTAGACCCTGAGCAGAATAGTCACTTTGTTG
ATCATTATCTAGAAGTAGAATATGATCTATCAAATGTAATATTTATTGCTACTGCTAACTCTCATGATTTACCTAGAGCT
TTAAGTGATAGAATGGAAAAAATATATATTTCCGGTTATGTAGAGGAAACAAAGCTCCAAATTGCCAGAAATTATTTAGT
TCCAAAACAATTTAAAATGCATAAAATCAAAAAAGATGAAATTACTATATCCGAGACGGCAATTTTGGATTTAATTAGAT
ATTATACCAAGGAATCAGGTGTAAGAGCTTTAGAGCGTGAGATAGGGGCATTAACTAGAAAAGCATTAAAGCAGATTTTA
GCAGATAAAAGTGTTAAGCATATCGCCATAGATAGTAATCATCTTGAAGAATTTTTAGGAGCTAAGAAATATAATTTCGG
GCTTGCCGAGAAAGAAGATCAAATAGGAAGTACTACGGGACTTGCTTATACTGAAGTAGGCGGAGAGCTTTTAACTATAG
AGGCTTTAGCATTTCCAGGGAAAGGTGAAATAAAGACCACCGGAAAACTCGGTGATGTTATGAAAGAATCGGCAATGGCT
GCCTATAGTTGTTTTAGAAGCAGAGCAACAAATTTTGGATTAAAGTATGACAATTATAAAGATTTTGATATTCACATTCA
CGTACCGGCCGGAGCTATTCCAAAAGATGGACCGTCTGCCGGCTGTGCTTTGTTTACGACTATTGTTTCGTTGATGACTA
AAATACCCGTACATCGTACTGTAGCAATGACCGGTGAAATTACTTTAAGAGGCAATGTTTTACCTATAGGTGGTCTTAAA
GAGAAGTTACTTGCTGCAAGTAGGGGAGGTATTAAAACCGTGTTGATTCCTGAAGAAAATGTCAAAGATTTGAAAGATAT
ACCGCCGAATATAAAAGAAAGCTTAGAAATTATATCTGTATCAAATATTGATCAAGTACTTAAGCATGCTTTGGTAGGAA
CACCGATAAATAAATAG

Upstream 100 bases:

>100_bases
TAGTAATAAATTCATAAATATAATTAATAATGGTAGCTTGAAATCAGGTTGATACTATATTATATAGTTAATAATTAGAA
ATTTTAAAAGGTTTTAATTG

Downstream 100 bases:

>100_bases
AGATTTGTTAATAGTCAAAATATCATATATTAAATTAATGCAAGCTATAGTAAAGTAATTCTTTTTGACTTTTCAATCAA
AATGCGATTTTTCTTGCTTA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MHKKSLPLMALRDMVVFPGVIAPIFVGRPKSLQALSNTTIFEEDNSKYILVTLQKKFDQENPSTHELYNTAILAKIIQIV
KLPNNTAKILIEAVARVKLSNIKGEEAFEANYEIIPDEEIFDVNNMRSLVDNAVQLFSKYAINDKKVNAEIIETINKKIS
NSTNFIDIINILASHLITSLEAKQHLLEETSPFKRITTVISMLTSNIVNSETEQALQQRVRKQIEKTQRDYYLHEQMKAI
QKELDEDKSELADIEKKIKSLKLSKEAKEKAEAELKKLRTMNQMSAESGVTRNYLETLLSLPWGKYDNSKIDINQAEKIL
NRDHFGLEKVKERIIEYLAVLQRSSKIRGPILCLIGPPGVGKTSLVKSIAEGMGRKYTKLALGGVRDEAEIRGHRKTYLG
SMPGKILGQLKKVKTSNPVMLLDEIDKMSSDFRGDPASALLEVLDPEQNSHFVDHYLEVEYDLSNVIFIATANSHDLPRA
LSDRMEKIYISGYVEETKLQIARNYLVPKQFKMHKIKKDEITISETAILDLIRYYTKESGVRALEREIGALTRKALKQIL
ADKSVKHIAIDSNHLEEFLGAKKYNFGLAEKEDQIGSTTGLAYTEVGGELLTIEALAFPGKGEIKTTGKLGDVMKESAMA
AYSCFRSRATNFGLKYDNYKDFDIHIHVPAGAIPKDGPSAGCALFTTIVSLMTKIPVHRTVAMTGEITLRGNVLPIGGLK
EKLLAASRGGIKTVLIPEENVKDLKDIPPNIKESLEIISVSNIDQVLKHALVGTPINK

Sequences:

>Translated_778_residues
MHKKSLPLMALRDMVVFPGVIAPIFVGRPKSLQALSNTTIFEEDNSKYILVTLQKKFDQENPSTHELYNTAILAKIIQIV
KLPNNTAKILIEAVARVKLSNIKGEEAFEANYEIIPDEEIFDVNNMRSLVDNAVQLFSKYAINDKKVNAEIIETINKKIS
NSTNFIDIINILASHLITSLEAKQHLLEETSPFKRITTVISMLTSNIVNSETEQALQQRVRKQIEKTQRDYYLHEQMKAI
QKELDEDKSELADIEKKIKSLKLSKEAKEKAEAELKKLRTMNQMSAESGVTRNYLETLLSLPWGKYDNSKIDINQAEKIL
NRDHFGLEKVKERIIEYLAVLQRSSKIRGPILCLIGPPGVGKTSLVKSIAEGMGRKYTKLALGGVRDEAEIRGHRKTYLG
SMPGKILGQLKKVKTSNPVMLLDEIDKMSSDFRGDPASALLEVLDPEQNSHFVDHYLEVEYDLSNVIFIATANSHDLPRA
LSDRMEKIYISGYVEETKLQIARNYLVPKQFKMHKIKKDEITISETAILDLIRYYTKESGVRALEREIGALTRKALKQIL
ADKSVKHIAIDSNHLEEFLGAKKYNFGLAEKEDQIGSTTGLAYTEVGGELLTIEALAFPGKGEIKTTGKLGDVMKESAMA
AYSCFRSRATNFGLKYDNYKDFDIHIHVPAGAIPKDGPSAGCALFTTIVSLMTKIPVHRTVAMTGEITLRGNVLPIGGLK
EKLLAASRGGIKTVLIPEENVKDLKDIPPNIKESLEIISVSNIDQVLKHALVGTPINK
>Mature_778_residues
MHKKSLPLMALRDMVVFPGVIAPIFVGRPKSLQALSNTTIFEEDNSKYILVTLQKKFDQENPSTHELYNTAILAKIIQIV
KLPNNTAKILIEAVARVKLSNIKGEEAFEANYEIIPDEEIFDVNNMRSLVDNAVQLFSKYAINDKKVNAEIIETINKKIS
NSTNFIDIINILASHLITSLEAKQHLLEETSPFKRITTVISMLTSNIVNSETEQALQQRVRKQIEKTQRDYYLHEQMKAI
QKELDEDKSELADIEKKIKSLKLSKEAKEKAEAELKKLRTMNQMSAESGVTRNYLETLLSLPWGKYDNSKIDINQAEKIL
NRDHFGLEKVKERIIEYLAVLQRSSKIRGPILCLIGPPGVGKTSLVKSIAEGMGRKYTKLALGGVRDEAEIRGHRKTYLG
SMPGKILGQLKKVKTSNPVMLLDEIDKMSSDFRGDPASALLEVLDPEQNSHFVDHYLEVEYDLSNVIFIATANSHDLPRA
LSDRMEKIYISGYVEETKLQIARNYLVPKQFKMHKIKKDEITISETAILDLIRYYTKESGVRALEREIGALTRKALKQIL
ADKSVKHIAIDSNHLEEFLGAKKYNFGLAEKEDQIGSTTGLAYTEVGGELLTIEALAFPGKGEIKTTGKLGDVMKESAMA
AYSCFRSRATNFGLKYDNYKDFDIHIHVPAGAIPKDGPSAGCALFTTIVSLMTKIPVHRTVAMTGEITLRGNVLPIGGLK
EKLLAASRGGIKTVLIPEENVKDLKDIPPNIKESLEIISVSNIDQVLKHALVGTPINK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=832, Percent_Identity=37.3798076923077, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=602, Percent_Identity=42.5249169435216, Blast_Score=491, Evalue=1e-138,
Organism=Escherichia coli, GI1786643, Length=774, Percent_Identity=51.421188630491, Blast_Score=777, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=672, Percent_Identity=39.4345238095238, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17556486, Length=544, Percent_Identity=41.7279411764706, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=637, Percent_Identity=38.7755102040816, Blast_Score=453, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24666867, Length=607, Percent_Identity=42.339373970346, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI221513036, Length=607, Percent_Identity=42.339373970346, Blast_Score=465, Evalue=1e-131,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87038; Mature: 87038

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKSLPLMALRDMVVFPGVIAPIFVGRPKSLQALSNTTIFEEDNSKYILVTLQKKFDQE
CCCCCCCHHHHHHHHHHCHHHHHHHCCCCHHHHHHHCCEEEECCCCCEEEEEEEHHCCCC
NPSTHELYNTAILAKIIQIVKLPNNTAKILIEAVARVKLSNIKGEEAFEANYEIIPDEEI
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCEECCCCHH
FDVNNMRSLVDNAVQLFSKYAINDKKVNAEIIETINKKISNSTNFIDIINILASHLITSL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EAKQHLLEETSPFKRITTVISMLTSNIVNSETEQALQQRVRKQIEKTQRDYYLHEQMKAI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELDEDKSELADIEKKIKSLKLSKEAKEKAEAELKKLRTMNQMSAESGVTRNYLETLLS
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LPWGKYDNSKIDINQAEKILNRDHFGLEKVKERIIEYLAVLQRSSKIRGPILCLIGPPGV
CCCCCCCCCEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
GKTSLVKSIAEGMGRKYTKLALGGVRDEAEIRGHRKTYLGSMPGKILGQLKKVKTSNPVM
CHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCEE
LLDEIDKMSSDFRGDPASALLEVLDPEQNSHFVDHYLEVEYDLSNVIFIATANSHDLPRA
EHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHEEEEECCCCEEEEEECCCCCCHHH
LSDRMEKIYISGYVEETKLQIARNYLVPKQFKMHKIKKDEITISETAILDLIRYYTKESG
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHH
VRALEREIGALTRKALKQILADKSVKHIAIDSNHLEEFLGAKKYNFGLAEKEDQIGSTTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHCCCCCC
LAYTEVGGELLTIEALAFPGKGEIKTTGKLGDVMKESAMAAYSCFRSRATNFGLKYDNYK
CEEHHCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DFDIHIHVPAGAIPKDGPSAGCALFTTIVSLMTKIPVHRTVAMTGEITLRGNVLPIGGLK
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCEEECCCHH
EKLLAASRGGIKTVLIPEENVKDLKDIPPNIKESLEIISVSNIDQVLKHALVGTPINK
HHHHHHCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHKKSLPLMALRDMVVFPGVIAPIFVGRPKSLQALSNTTIFEEDNSKYILVTLQKKFDQE
CCCCCCCHHHHHHHHHHCHHHHHHHCCCCHHHHHHHCCEEEECCCCCEEEEEEEHHCCCC
NPSTHELYNTAILAKIIQIVKLPNNTAKILIEAVARVKLSNIKGEEAFEANYEIIPDEEI
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCEECCCCHH
FDVNNMRSLVDNAVQLFSKYAINDKKVNAEIIETINKKISNSTNFIDIINILASHLITSL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EAKQHLLEETSPFKRITTVISMLTSNIVNSETEQALQQRVRKQIEKTQRDYYLHEQMKAI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELDEDKSELADIEKKIKSLKLSKEAKEKAEAELKKLRTMNQMSAESGVTRNYLETLLS
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LPWGKYDNSKIDINQAEKILNRDHFGLEKVKERIIEYLAVLQRSSKIRGPILCLIGPPGV
CCCCCCCCCEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
GKTSLVKSIAEGMGRKYTKLALGGVRDEAEIRGHRKTYLGSMPGKILGQLKKVKTSNPVM
CHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCEE
LLDEIDKMSSDFRGDPASALLEVLDPEQNSHFVDHYLEVEYDLSNVIFIATANSHDLPRA
EHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHEEEEECCCCEEEEEECCCCCCHHH
LSDRMEKIYISGYVEETKLQIARNYLVPKQFKMHKIKKDEITISETAILDLIRYYTKESG
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHH
VRALEREIGALTRKALKQILADKSVKHIAIDSNHLEEFLGAKKYNFGLAEKEDQIGSTTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHCCCCCC
LAYTEVGGELLTIEALAFPGKGEIKTTGKLGDVMKESAMAAYSCFRSRATNFGLKYDNYK
CEEHHCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DFDIHIHVPAGAIPKDGPSAGCALFTTIVSLMTKIPVHRTVAMTGEITLRGNVLPIGGLK
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCEEECCCHH
EKLLAASRGGIKTVLIPEENVKDLKDIPPNIKESLEIISVSNIDQVLKHALVGTPINK
HHHHHHCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]