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The map label for this gene is folE [H]

Identifier: 229586652

GI number: 229586652

Start: 518905

End: 519474

Strand: Direct

Name: folE [H]

Synonym: RAF_ORF0489

Alternate gene names: 229586652

Gene position: 518905-519474 (Clockwise)

Preceding gene: 229586651

Following gene: 229586653

Centisome position: 40.59

GC content: 35.09

Gene sequence:

>570_bases
ATGAGTAAACCAACTAGAGAAGAAGCTACAGAGGCAGTAAGAACGTTACTAAAATTCATTGGTGAAGATCCAAGCAGAGA
AGGGTTGCTTCAAACGCCTGATAGAGTAATTAATAGCTACGTAGAAATATTTTCCGGTTATGGAAAGGATGTAGCAGAAA
TATTAAATACCAAGTTTTATGAAACTTGTAATTTTCAAGATTTTATCTTACTGAATATAAAATTTACCTCTTTCTGTGAA
CATCATATATTACCTTTTAACGGTACAGTAGATATAGCTTATATTCCTGATAATTGTATTGTCGGCATAAGTAAGCTAGC
ACGAATAGTAAATATTTTTGCTAGAAGACTACAAATCCAAGAAAAAATGACGGTACAGATAGCAGAAAGCGTGCAGGAGA
ATTTAAAGCCGCTTGGCGTTGCCGTTAAGATTTCTGCCGTACATAGCTGTATGTCAATGCGTGGCGTAATGCAAGATAAT
AGTGTTATGAATACCATGCATTATACGGGTATATTTGCCGAACAGCAGAAATATCGTCATGAGTTTTTAAACCTTACTGC
TAAAAGGTGA

Upstream 100 bases:

>100_bases
GGAATGATGGGCGGAGGAGGGGTTATTGCTATAGTAGGCGGCTTGATGTTTGTATATATTTGTGTTAAAGTAATATTTTT
TAAAAGTATAAAACTAGCAC

Downstream 100 bases:

>100_bases
TACGTTATTAATGTCATTTCTGCGGAAGTGGGAATCCAGTCATTTTGTCATACCGTGACTTGATTGCGGTATCCAGAAAA
AAATTTAAAAAAACTGGATC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MSKPTREEATEAVRTLLKFIGEDPSREGLLQTPDRVINSYVEIFSGYGKDVAEILNTKFYETCNFQDFILLNIKFTSFCE
HHILPFNGTVDIAYIPDNCIVGISKLARIVNIFARRLQIQEKMTVQIAESVQENLKPLGVAVKISAVHSCMSMRGVMQDN
SVMNTMHYTGIFAEQQKYRHEFLNLTAKR

Sequences:

>Translated_189_residues
MSKPTREEATEAVRTLLKFIGEDPSREGLLQTPDRVINSYVEIFSGYGKDVAEILNTKFYETCNFQDFILLNIKFTSFCE
HHILPFNGTVDIAYIPDNCIVGISKLARIVNIFARRLQIQEKMTVQIAESVQENLKPLGVAVKISAVHSCMSMRGVMQDN
SVMNTMHYTGIFAEQQKYRHEFLNLTAKR
>Mature_188_residues
SKPTREEATEAVRTLLKFIGEDPSREGLLQTPDRVINSYVEIFSGYGKDVAEILNTKFYETCNFQDFILLNIKFTSFCEH
HILPFNGTVDIAYIPDNCIVGISKLARIVNIFARRLQIQEKMTVQIAESVQENLKPLGVAVKISAVHSCMSMRGVMQDNS
VMNTMHYTGIFAEQQKYRHEFLNLTAKR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=174, Percent_Identity=43.1034482758621, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI4503949, Length=174, Percent_Identity=43.1034482758621, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI66932970, Length=162, Percent_Identity=38.2716049382716, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI66932972, Length=138, Percent_Identity=40.5797101449275, Blast_Score=123, Evalue=1e-28,
Organism=Escherichia coli, GI1788476, Length=171, Percent_Identity=38.0116959064327, Blast_Score=110, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=43.2584269662921, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321706, Length=179, Percent_Identity=41.340782122905, Blast_Score=144, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24656782, Length=186, Percent_Identity=43.5483870967742, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24656791, Length=186, Percent_Identity=43.5483870967742, Blast_Score=152, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24656796, Length=186, Percent_Identity=43.5483870967742, Blast_Score=152, Evalue=9e-38,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21571; Mature: 21440

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPTREEATEAVRTLLKFIGEDPSREGLLQTPDRVINSYVEIFSGYGKDVAEILNTKFY
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETCNFQDFILLNIKFTSFCEHHILPFNGTVDIAYIPDNCIVGISKLARIVNIFARRLQIQ
HCCCCCEEEEEEEEHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
EKMTVQIAESVQENLKPLGVAVKISAVHSCMSMRGVMQDNSVMNTMHYTGIFAEQQKYRH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EFLNLTAKR
HHHHHHCCC
>Mature Secondary Structure 
SKPTREEATEAVRTLLKFIGEDPSREGLLQTPDRVINSYVEIFSGYGKDVAEILNTKFY
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETCNFQDFILLNIKFTSFCEHHILPFNGTVDIAYIPDNCIVGISKLARIVNIFARRLQIQ
HCCCCCEEEEEEEEHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
EKMTVQIAESVQENLKPLGVAVKISAVHSCMSMRGVMQDNSVMNTMHYTGIFAEQQKYRH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EFLNLTAKR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA