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The map label for this gene is pdhA [H]

Identifier: 229586511

GI number: 229586511

Start: 351712

End: 352692

Strand: Direct

Name: pdhA [H]

Synonym: RAF_ORF0323

Alternate gene names: 229586511

Gene position: 351712-352692 (Clockwise)

Preceding gene: 229586510

Following gene: 229586512

Centisome position: 27.51

GC content: 38.84

Gene sequence:

>981_bases
GTGGATATTAAGTTAGGAAAATATAAGCCGACAAAGGAAGAATATATAAAAAGCTTTAAAGATATGCTCCTACTGCGTCG
TTTTGAAGAAAAATGCGGTCAGTTATACGGAATGGGAGAAATCGGTGGTTTTTGTCATTTATATATAGGGCAAGAAGCAG
TAATTTCTGCGGTAGATATGGTTAAACACAAAGGTGATAGCACTATTACTAGCTATCGTGACCATGCTCATATTATTTTA
GCAGGCACTGAGCCTAAGTATGTTCTTGCCGAGCTTATGGGGCGTGCTACAGGTTGCTCGAAAGGTAAGGGTGGCTCGAT
GCATTTATTTAATGTACCAAACAAATTTTACGGTGGACACGGTATAGTAGGGGCTCAAGTACCGATAGGCACAGGGCTTG
CGTTTGCTGAAAAATATAACGATACGCATAATATCTGTTTTACTTTTTTAGGTGACGGTGCCGTTAATCAAGGTCAGGTA
TATGAAGCTTTTAATATGGCTGCTTTATGGGGTTTGCCGGTAGTTTATATTATTGAAAATAACGAATATTCGATGGGGAC
GTCTGTAGCACGTTCTACCTTTATGCGTGATTTATATAAGAAAGGGGCATCGTTTGGGATTAAAGGATTTCAGCTAGACG
GTATGGATTTTGAAGAAATGTATGACGGCTCTAAGCAAGCAGCCGAGTATGTTAGAGAAAATAGCTTTCCTCTGATATTA
GAGGTAAAAACTTATCGTTATCGTGGGCATTCGATGTCCGATCCGGCAAAATATCGTAGTAAAGAAGAAGTTGAGCAATA
TAAAGAGCGTGATCCGTTGGTAATAATAAGAAAAACGATACTCGACAATAAATATGTAACCGAAGCGGATTTAAAAGCAA
TAGAACAGTCGGTAAAAGAAATTGTGAAAGAAGCAGTAGAATTCTCAGAAAATTCACCGCTACCTGATGAAGGGGAGTTG
TATACACAGGTGTACTGTTAA

Upstream 100 bases:

>100_bases
TCTTCACCTTCGGATCATGTACCATATTTTGTGACTTTTAATTTACAGATGTCATCCCGTGGTCAAGCCACGGGATGACA
ATAGTCTTAAGGAGTAATTA

Downstream 100 bases:

>100_bases
GGTGTCATTGCGAGGAAAAACTGTAAGTTTTGACGAAGCAATCTCAGGAATTTGTTATTATTTCATGAGATTGTCACGCA
GCCTACGGCTGCTCGTAATG

Product: Pyruvate dehydrogenase e1 component, alpha subunit precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MDIKLGKYKPTKEEYIKSFKDMLLLRRFEEKCGQLYGMGEIGGFCHLYIGQEAVISAVDMVKHKGDSTITSYRDHAHIIL
AGTEPKYVLAELMGRATGCSKGKGGSMHLFNVPNKFYGGHGIVGAQVPIGTGLAFAEKYNDTHNICFTFLGDGAVNQGQV
YEAFNMAALWGLPVVYIIENNEYSMGTSVARSTFMRDLYKKGASFGIKGFQLDGMDFEEMYDGSKQAAEYVRENSFPLIL
EVKTYRYRGHSMSDPAKYRSKEEVEQYKERDPLVIIRKTILDNKYVTEADLKAIEQSVKEIVKEAVEFSENSPLPDEGEL
YTQVYC

Sequences:

>Translated_326_residues
MDIKLGKYKPTKEEYIKSFKDMLLLRRFEEKCGQLYGMGEIGGFCHLYIGQEAVISAVDMVKHKGDSTITSYRDHAHIIL
AGTEPKYVLAELMGRATGCSKGKGGSMHLFNVPNKFYGGHGIVGAQVPIGTGLAFAEKYNDTHNICFTFLGDGAVNQGQV
YEAFNMAALWGLPVVYIIENNEYSMGTSVARSTFMRDLYKKGASFGIKGFQLDGMDFEEMYDGSKQAAEYVRENSFPLIL
EVKTYRYRGHSMSDPAKYRSKEEVEQYKERDPLVIIRKTILDNKYVTEADLKAIEQSVKEIVKEAVEFSENSPLPDEGEL
YTQVYC
>Mature_326_residues
MDIKLGKYKPTKEEYIKSFKDMLLLRRFEEKCGQLYGMGEIGGFCHLYIGQEAVISAVDMVKHKGDSTITSYRDHAHIIL
AGTEPKYVLAELMGRATGCSKGKGGSMHLFNVPNKFYGGHGIVGAQVPIGTGLAFAEKYNDTHNICFTFLGDGAVNQGQV
YEAFNMAALWGLPVVYIIENNEYSMGTSVARSTFMRDLYKKGASFGIKGFQLDGMDFEEMYDGSKQAAEYVRENSFPLIL
EVKTYRYRGHSMSDPAKYRSKEEVEQYKERDPLVIIRKTILDNKYVTEADLKAIEQSVKEIVKEAVEFSENSPLPDEGEL
YTQVYC

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=317, Percent_Identity=46.0567823343849, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI4505685, Length=317, Percent_Identity=43.8485804416404, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI291084742, Length=317, Percent_Identity=43.8485804416404, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI291084744, Length=324, Percent_Identity=42.9012345679012, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI291084757, Length=317, Percent_Identity=38.4858044164038, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI11386135, Length=322, Percent_Identity=25.1552795031056, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI258645172, Length=322, Percent_Identity=25.4658385093168, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17536047, Length=317, Percent_Identity=44.4794952681388, Blast_Score=273, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI32564172, Length=317, Percent_Identity=44.4794952681388, Blast_Score=273, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI86563357, Length=281, Percent_Identity=25.2669039145907, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI86563355, Length=281, Percent_Identity=25.2669039145907, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6321026, Length=311, Percent_Identity=46.9453376205788, Blast_Score=289, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24639740, Length=319, Percent_Identity=43.2601880877743, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24639744, Length=319, Percent_Identity=43.2601880877743, Blast_Score=264, Evalue=5e-71,
Organism=Drosophila melanogaster, GI28571106, Length=319, Percent_Identity=43.2601880877743, Blast_Score=264, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=43.7908496732026, Blast_Score=257, Evalue=9e-69,
Organism=Drosophila melanogaster, GI24639748, Length=327, Percent_Identity=41.5902140672783, Blast_Score=253, Evalue=9e-68,
Organism=Drosophila melanogaster, GI21355903, Length=314, Percent_Identity=24.203821656051, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36703; Mature: 36703

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKLGKYKPTKEEYIKSFKDMLLLRRFEEKCGQLYGMGEIGGFCHLYIGQEAVISAVDM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECHHHHHHHHHH
VKHKGDSTITSYRDHAHIILAGTEPKYVLAELMGRATGCSKGKGGSMHLFNVPNKFYGGH
HHHCCCCCHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHCCCC
GIVGAQVPIGTGLAFAEKYNDTHNICFTFLGDGAVNQGQVYEAFNMAALWGLPVVYIIEN
CEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEC
NEYSMGTSVARSTFMRDLYKKGASFGIKGFQLDGMDFEEMYDGSKQAAEYVRENSFPLIL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHCCHHHHHHHHHCCCCCEEE
EVKTYRYRGHSMSDPAKYRSKEEVEQYKERDPLVIIRKTILDNKYVTEADLKAIEQSVKE
EEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHH
IVKEAVEFSENSPLPDEGELYTQVYC
HHHHHHHHCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MDIKLGKYKPTKEEYIKSFKDMLLLRRFEEKCGQLYGMGEIGGFCHLYIGQEAVISAVDM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECHHHHHHHHHH
VKHKGDSTITSYRDHAHIILAGTEPKYVLAELMGRATGCSKGKGGSMHLFNVPNKFYGGH
HHHCCCCCHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHCCCC
GIVGAQVPIGTGLAFAEKYNDTHNICFTFLGDGAVNQGQVYEAFNMAALWGLPVVYIIEN
CEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEC
NEYSMGTSVARSTFMRDLYKKGASFGIKGFQLDGMDFEEMYDGSKQAAEYVRENSFPLIL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHCCHHHHHHHHHCCCCCEEE
EVKTYRYRGHSMSDPAKYRSKEEVEQYKERDPLVIIRKTILDNKYVTEADLKAIEQSVKE
EEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHH
IVKEAVEFSENSPLPDEGELYTQVYC
HHHHHHHHCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA