Click here to switch to the map view.

The map label for this gene is era [H]

Identifier: 229586356

GI number: 229586356

Start: 158759

End: 159778

Strand: Direct

Name: era [H]

Synonym: RAF_ORF0147

Alternate gene names: 229586356

Gene position: 158759-159778 (Clockwise)

Preceding gene: 229586355

Following gene: 229586357

Centisome position: 12.42

GC content: 34.9

Gene sequence:

>1020_bases
ATGACTAATAGACATCTTGCCAAATTCGCTTATAGAGAGGAATTTAAAGGAGACACGGAAGCACTTGCCGCCGCAGTACG
CGAGGATACGAGTACTGGATCGACGTCTCAATTACCTCTAGAAGTGCAGTTTGGGAAGATGCCTAATCAGAAAACGGTAT
CGGTTTGTATAATCGGGCGACCTAATAGCGGAAAATCAACTTTATTAAACAGAATAATCGGTGAGAAGCTTTCAATCGTT
ACCCCAAAAGTTCAAACTACTAGGTCAATTATTACCGGTATTATTACCTTAAAAGATACACAGGTAATTTTATACGATAC
GCCCGGTATATTTGAGCCGAAAGGGAGCTTAGAGAAAGCAATGGTAAGATGTGCGTGGTCTAGTTTGCATAGTGCGGATT
TAGTTCTGTTAATTATTGATAGTCTAAAGTCGTTTGATGATATAACGCATAATATTGTAGATAAGCTTCGCTCACTTAAT
ATTGTTCCGATATTTTTATTGAACAAAATAGACATCGAATCAAAATATCTAAATGACATTAAAGCTTTTTTAACAGAAAA
TCATCCTGATAGCTTGCTTTTTCCTATATCTGCTTTATCAGGCAAAAATATTGATGGATTACTTGAATATATCACAAGTA
AGGCCAAAATTTCTCCTTGGCTTTATGCGGAAGACGACATAACGGATTTACCTATGCGTTTTATTGCAGCAGAAATTACA
AGAGAGCAGTTATTTTTAAATTTGCAGAAAGAACTCCCTTATAAATTAACCGTACAAACCGAAAAATGGGAAGATCTTAA
AGACAAATCCGTAAAGATTAATCAAGTTATAGTAGTTTCAAGAGAGAGCTATAAAACTATAATACTCGGTAAAAATGGCT
CTAAAATCAAAGAAATAGGAGCAAAATCCCGAATGCAAATGGAGAGATTTTTTGGATTTCCTGTTCATTTATTTTTATTC
GTTAAGGTGCGTGAGCTGTGGGAGAATAATCAAGAATTTTATCAGTATATGAAGATATAA

Upstream 100 bases:

>100_bases
GTTCTTGTAAAAGTAAAAGATTATGAACAAACAGGCACTGGTCACGCAATAAAAGAAGCAGAGAAAAACGCAGCACGCAG
CTTATTGCATAGACTTAAAA

Downstream 100 bases:

>100_bases
AGCTGTCACCCTGTGGCTTGACAGGCTTTGTTGGATCGTTTTCGATGTCATTCCCCGAAAGCGGGAATGACATAAAAGCC
ATATAATAATACCAATAAAA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTNRHLAKFAYREEFKGDTEALAAAVREDTSTGSTSQLPLEVQFGKMPNQKTVSVCIIGRPNSGKSTLLNRIIGEKLSIV
TPKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKAMVRCAWSSLHSADLVLLIIDSLKSFDDITHNIVDKLRSLN
IVPIFLLNKIDIESKYLNDIKAFLTENHPDSLLFPISALSGKNIDGLLEYITSKAKISPWLYAEDDITDLPMRFIAAEIT
REQLFLNLQKELPYKLTVQTEKWEDLKDKSVKINQVIVVSRESYKTIILGKNGSKIKEIGAKSRMQMERFFGFPVHLFLF
VKVRELWENNQEFYQYMKI

Sequences:

>Translated_339_residues
MTNRHLAKFAYREEFKGDTEALAAAVREDTSTGSTSQLPLEVQFGKMPNQKTVSVCIIGRPNSGKSTLLNRIIGEKLSIV
TPKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKAMVRCAWSSLHSADLVLLIIDSLKSFDDITHNIVDKLRSLN
IVPIFLLNKIDIESKYLNDIKAFLTENHPDSLLFPISALSGKNIDGLLEYITSKAKISPWLYAEDDITDLPMRFIAAEIT
REQLFLNLQKELPYKLTVQTEKWEDLKDKSVKINQVIVVSRESYKTIILGKNGSKIKEIGAKSRMQMERFFGFPVHLFLF
VKVRELWENNQEFYQYMKI
>Mature_338_residues
TNRHLAKFAYREEFKGDTEALAAAVREDTSTGSTSQLPLEVQFGKMPNQKTVSVCIIGRPNSGKSTLLNRIIGEKLSIVT
PKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKAMVRCAWSSLHSADLVLLIIDSLKSFDDITHNIVDKLRSLNI
VPIFLLNKIDIESKYLNDIKAFLTENHPDSLLFPISALSGKNIDGLLEYITSKAKISPWLYAEDDITDLPMRFIAAEITR
EQLFLNLQKELPYKLTVQTEKWEDLKDKSVKINQVIVVSRESYKTIILGKNGSKIKEIGAKSRMQMERFFGFPVHLFLFV
KVRELWENNQEFYQYMKI

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RPE1 insert domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=339, Percent_Identity=30.6784660766962, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1788919, Length=280, Percent_Identity=37.5, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI2367268, Length=171, Percent_Identity=29.2397660818713, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507259, Length=136, Percent_Identity=30.1470588235294, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24646434, Length=341, Percent_Identity=25.5131964809384, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005728
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 38622; Mature: 38491

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRHLAKFAYREEFKGDTEALAAAVREDTSTGSTSQLPLEVQFGKMPNQKTVSVCIIGR
CCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEC
PNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKA
CCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHEEEEEECCEEEEECCCCCCCCCCHHHHH
MVRCAWSSLHSADLVLLIIDSLKSFDDITHNIVDKLRSLNIVPIFLLNKIDIESKYLNDI
HHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHH
KAFLTENHPDSLLFPISALSGKNIDGLLEYITSKAKISPWLYAEDDITDLPMRFIAAEIT
HHHHCCCCCCCEEEEEHHCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHH
REQLFLNLQKELPYKLTVQTEKWEDLKDKSVKINQVIVVSRESYKTIILGKNGSKIKEIG
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCCHHHHHH
AKSRMQMERFFGFPVHLFLFVKVRELWENNQEFYQYMKI
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
TNRHLAKFAYREEFKGDTEALAAAVREDTSTGSTSQLPLEVQFGKMPNQKTVSVCIIGR
CCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEC
PNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKA
CCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHEEEEEECCEEEEECCCCCCCCCCHHHHH
MVRCAWSSLHSADLVLLIIDSLKSFDDITHNIVDKLRSLNIVPIFLLNKIDIESKYLNDI
HHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHH
KAFLTENHPDSLLFPISALSGKNIDGLLEYITSKAKISPWLYAEDDITDLPMRFIAAEIT
HHHHCCCCCCCEEEEEHHCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHH
REQLFLNLQKELPYKLTVQTEKWEDLKDKSVKINQVIVVSRESYKTIILGKNGSKIKEIG
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCCHHHHHH
AKSRMQMERFFGFPVHLFLFVKVRELWENNQEFYQYMKI
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]