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The map label for this gene is rnc

Identifier: 229586355

GI number: 229586355

Start: 158083

End: 158766

Strand: Direct

Name: rnc

Synonym: RAF_ORF0146

Alternate gene names: 229586355

Gene position: 158083-158766 (Clockwise)

Preceding gene: 229586354

Following gene: 229586356

Centisome position: 12.36

GC content: 33.33

Gene sequence:

>684_bases
ATGGAATCATTTGAGAAGTTAGAAAAGCTACTTAGCTATAGTTTCAAAAATAAAGAGCTTTTAATAGAGGCGTTGAGTCA
CCCGTCTTTAAGGCAACATCACGAGTACAAGGATGATAAAGATTATGAACGATTAGAATTTCTAGGTGATGCTGTATTAA
ATTTAGTAATCACAGAAATTTTATTTAGAAATTTTGCAAATTATAATGAGGGGAATTTAGCTAAAATTAGATCATATTTG
GTTTGCAAAGAAACAATATGCATGGTTGGAGCTAAACTTACTTTAAAAAATTATATAATTATGACTCATGGCGAAGAAGT
AGCAGGCGGGCGTGATAATCTTAATAATATAGAAAATGCCACAGAAGCTTTAATTGCAGCTATATATCTTGATAGCAATA
TTGAAACAACCCATGATATTATCGAGAAGTTATGGGCAGAATTTATAAAAGTTCAGAATTTAACGGATTATGACCCAAAA
ACTGCTTTACAAGAATGGGCTCAAGCTAGTGATCATCACCTACCTATATATCGTCTGATCAAAAGAGAAGGAGCCTCCCA
TTCATCGACTTTTACGGTTCTTGTAAAAGTAAAAGATTATGAACAAACAGGCACTGGTCACGCAATAAAAGAAGCAGAGA
AAAACGCAGCACGCAGCTTATTGCATAGACTTAAAAATGACTAA

Upstream 100 bases:

>100_bases
ATGATATAGGAGTTATTAATCTAGTACTAAAGTTAAAGCCATGGATTGAATCTGTTAGGTTAAATCGAATTTTCAGAAAT
CTTTATAACACGGATGCGTA

Downstream 100 bases:

>100_bases
TAGACATCTTGCCAAATTCGCTTATAGAGAGGAATTTAAAGGAGACACGGAAGCACTTGCCGCCGCAGTACGCGAGGATA
CGAGTACTGGATCGACGTCT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MESFEKLEKLLSYSFKNKELLIEALSHPSLRQHHEYKDDKDYERLEFLGDAVLNLVITEILFRNFANYNEGNLAKIRSYL
VCKETICMVGAKLTLKNYIIMTHGEEVAGGRDNLNNIENATEALIAAIYLDSNIETTHDIIEKLWAEFIKVQNLTDYDPK
TALQEWAQASDHHLPIYRLIKREGASHSSTFTVLVKVKDYEQTGTGHAIKEAEKNAARSLLHRLKND

Sequences:

>Translated_227_residues
MESFEKLEKLLSYSFKNKELLIEALSHPSLRQHHEYKDDKDYERLEFLGDAVLNLVITEILFRNFANYNEGNLAKIRSYL
VCKETICMVGAKLTLKNYIIMTHGEEVAGGRDNLNNIENATEALIAAIYLDSNIETTHDIIEKLWAEFIKVQNLTDYDPK
TALQEWAQASDHHLPIYRLIKREGASHSSTFTVLVKVKDYEQTGTGHAIKEAEKNAARSLLHRLKND
>Mature_227_residues
MESFEKLEKLLSYSFKNKELLIEALSHPSLRQHHEYKDDKDYERLEFLGDAVLNLVITEILFRNFANYNEGNLAKIRSYL
VCKETICMVGAKLTLKNYIIMTHGEEVAGGRDNLNNIENATEALIAAIYLDSNIETTHDIIEKLWAEFIKVQNLTDYDPK
TALQEWAQASDHHLPIYRLIKREGASHSSTFTVLVKVKDYEQTGTGHAIKEAEKNAARSLLHRLKND

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=191, Percent_Identity=31.9371727748691, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI155030236, Length=191, Percent_Identity=31.9371727748691, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788920, Length=224, Percent_Identity=32.1428571428571, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193202651, Length=206, Percent_Identity=27.6699029126214, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506883, Length=206, Percent_Identity=27.6699029126214, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137682, Length=237, Percent_Identity=26.5822784810127, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_RICAE (C3PMF3)

Other databases:

- EMBL:   CP001612
- RefSeq:   YP_002844856.1
- ProteinModelPortal:   C3PMF3
- SMR:   C3PMF3
- GeneID:   7815395
- GenomeReviews:   CP001612_GR
- KEGG:   raf:RAF_ORF0146
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26067; Mature: 26067

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESFEKLEKLLSYSFKNKELLIEALSHPSLRQHHEYKDDKDYERLEFLGDAVLNLVITEI
CCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LFRNFANYNEGNLAKIRSYLVCKETICMVGAKLTLKNYIIMTHGEEVAGGRDNLNNIENA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCEEEEECCCHHCCCCCCHHHHHHH
TEALIAAIYLDSNIETTHDIIEKLWAEFIKVQNLTDYDPKTALQEWAQASDHHLPIYRLI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
KREGASHSSTFTVLVKVKDYEQTGTGHAIKEAEKNAARSLLHRLKND
HHCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MESFEKLEKLLSYSFKNKELLIEALSHPSLRQHHEYKDDKDYERLEFLGDAVLNLVITEI
CCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LFRNFANYNEGNLAKIRSYLVCKETICMVGAKLTLKNYIIMTHGEEVAGGRDNLNNIENA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCEEEEECCCHHCCCCCCHHHHHHH
TEALIAAIYLDSNIETTHDIIEKLWAEFIKVQNLTDYDPKTALQEWAQASDHHLPIYRLI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
KREGASHSSTFTVLVKVKDYEQTGTGHAIKEAEKNAARSLLHRLKND
HHCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA