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The map label for this gene is acdA [H]

Identifier: 227828788

GI number: 227828788

Start: 2380796

End: 2381992

Strand: Direct

Name: acdA [H]

Synonym: M1425_2562

Alternate gene names: 227828788

Gene position: 2380796-2381992 (Clockwise)

Preceding gene: 227828787

Following gene: 227828789

Centisome position: 91.26

GC content: 36.68

Gene sequence:

>1197_bases
ATGGTATTTCCTTTTAAGTCCTTGGAGGATTTTAAAGTAGAAATAACGCAAGATCATGAATTATTAAGAAGTGCAGTTAG
GGATTTTGCTGAAAATATATTGGCAAAGTATGTTGAAAGAGGTGAAAAAGAATTAGATATTCCTTTAGAGGTTAAACAAA
AGGCTAAGGAAATAGGCCTATATGGCTTATTTGCTAGACAAGATTTAGGGGGACAAGGAGCGGATTATTTATCATTGCTT
ACAGCAACAGAGGAGATGGCTAGAATTTGGCCCTCATTTAGCACATTTTTATTAATAAATTGGATGTTTATTTATGCGTT
ATCTAGGTTTGGAAACGAAGAATTAAAGAAAAAATATGTCACACCAGTAGCTAATGGCGATAAAGTAGCTGCATTTGCTG
TTACTGAGCCTGTGGCTGGATCAGATGTAGCTGGTATAAAGACAACAGCAAAGAAATTAGATAGTGAATATGTGATAAAT
GGAAGAAAGATTTTCATAACTAATGGTGATATTGCTGATTATTACTTAATTGCAGCTAGAACATCACCTCCAGATCCTAA
GGCCAGATGGAAAGGCATATCAATGCTTGTTGTGGAGAAAGACGCAGTGAAACCAGTAAGTAGAATCGAAACTACTGGAT
TAAAGTCCTCACATACTGCTGAAATTTTACTTGAGGATGTGAAAACACCCGCCGAAAATCTACTAGGAGAGGAAGGCAAT
GGATTTAAATATGCGGTAAGTTCTTTTGATTTCGCTAGGACCATAGTAGCTTCACAAGCCTTAGGAATTGGACAAGCTGC
ATTAGAGAAAATGATAAATTATTCACTTCAAAGAACTGCATTCGAAAAGAAACTAGCGGAATTTCAATTAGTTCAAACCA
AAGTTTCTGAATCGTTAGCGGATTTGGAAGTGGCAAGACTAATAACCTATTGGGCCGGGACATTGTTCAAGAATGGTAAA
GAAAACGAATACACAGTAGCAGCATCGTTGGCGAAATTCATATCCACCGAATCTGCTGAAAGAATTATATTAAGGGCTAT
GAGTGTCTACGGTGGTTATGGCGTTACTACCTCTACCGGATTGGAGAGAATGCTAAGGGATCTACAAATAATGAAAACAT
ATGAAGGGACAAACGATATTCAAAGGATTAGTGCAGCAAGATTTCTTTACAATAAATTCATTGGTTATAAGGTGTGA

Upstream 100 bases:

>100_bases
AAACGCGGATTACTTGGTTGTAGGCAACGCAATCGATTTCTGTAAAGTTATGTTAAGTAAGCTAGGGAAAAAATAATAAT
GATAAAAACGATTTTATTTT

Downstream 100 bases:

>100_bases
CCTTGTATATTGGTAGTCCAGTTAAGAGAGTTGAAGATTTACGATTTTTGACTGGAAAAGGTAGATACATTGACGACATT
TACTTTCCTAACATGCTATA

Product: acyl-CoA dehydrogenase domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MVFPFKSLEDFKVEITQDHELLRSAVRDFAENILAKYVERGEKELDIPLEVKQKAKEIGLYGLFARQDLGGQGADYLSLL
TATEEMARIWPSFSTFLLINWMFIYALSRFGNEELKKKYVTPVANGDKVAAFAVTEPVAGSDVAGIKTTAKKLDSEYVIN
GRKIFITNGDIADYYLIAARTSPPDPKARWKGISMLVVEKDAVKPVSRIETTGLKSSHTAEILLEDVKTPAENLLGEEGN
GFKYAVSSFDFARTIVASQALGIGQAALEKMINYSLQRTAFEKKLAEFQLVQTKVSESLADLEVARLITYWAGTLFKNGK
ENEYTVAASLAKFISTESAERIILRAMSVYGGYGVTTSTGLERMLRDLQIMKTYEGTNDIQRISAARFLYNKFIGYKV

Sequences:

>Translated_398_residues
MVFPFKSLEDFKVEITQDHELLRSAVRDFAENILAKYVERGEKELDIPLEVKQKAKEIGLYGLFARQDLGGQGADYLSLL
TATEEMARIWPSFSTFLLINWMFIYALSRFGNEELKKKYVTPVANGDKVAAFAVTEPVAGSDVAGIKTTAKKLDSEYVIN
GRKIFITNGDIADYYLIAARTSPPDPKARWKGISMLVVEKDAVKPVSRIETTGLKSSHTAEILLEDVKTPAENLLGEEGN
GFKYAVSSFDFARTIVASQALGIGQAALEKMINYSLQRTAFEKKLAEFQLVQTKVSESLADLEVARLITYWAGTLFKNGK
ENEYTVAASLAKFISTESAERIILRAMSVYGGYGVTTSTGLERMLRDLQIMKTYEGTNDIQRISAARFLYNKFIGYKV
>Mature_398_residues
MVFPFKSLEDFKVEITQDHELLRSAVRDFAENILAKYVERGEKELDIPLEVKQKAKEIGLYGLFARQDLGGQGADYLSLL
TATEEMARIWPSFSTFLLINWMFIYALSRFGNEELKKKYVTPVANGDKVAAFAVTEPVAGSDVAGIKTTAKKLDSEYVIN
GRKIFITNGDIADYYLIAARTSPPDPKARWKGISMLVVEKDAVKPVSRIETTGLKSSHTAEILLEDVKTPAENLLGEEGN
GFKYAVSSFDFARTIVASQALGIGQAALEKMINYSLQRTAFEKKLAEFQLVQTKVSESLADLEVARLITYWAGTLFKNGK
ENEYTVAASLAKFISTESAERIILRAMSVYGGYGVTTSTGLERMLRDLQIMKTYEGTNDIQRISAARFLYNKFIGYKV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=35.15625, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=35.2331606217617, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=35.2331606217617, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI4501859, Length=391, Percent_Identity=33.2480818414322, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI7656849, Length=367, Percent_Identity=31.0626702997275, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4501857, Length=387, Percent_Identity=31.5245478036176, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI21361497, Length=394, Percent_Identity=30.4568527918782, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=30.3896103896104, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=31.6860465116279, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI76496475, Length=401, Percent_Identity=30.1745635910224, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI4557235, Length=398, Percent_Identity=30.1507537688442, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=26.1324041811847, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=26.1324041811847, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=25.7217847769029, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38505218, Length=345, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI7669494, Length=369, Percent_Identity=24.9322493224932, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87081958, Length=378, Percent_Identity=28.3068783068783, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786223, Length=385, Percent_Identity=26.4935064935065, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17570075, Length=383, Percent_Identity=35.7702349869452, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=32.1989528795811, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=30.9895833333333, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17506239, Length=397, Percent_Identity=29.2191435768262, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17508101, Length=379, Percent_Identity=28.7598944591029, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17538396, Length=396, Percent_Identity=28.2828282828283, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17533517, Length=383, Percent_Identity=30.2872062663185, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=31.8181818181818, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17551932, Length=330, Percent_Identity=29.6969696969697, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=290, Percent_Identity=30, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17505929, Length=324, Percent_Identity=28.7037037037037, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=31.095406360424, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=30.4721030042918, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=29.9003322259136, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=385, Percent_Identity=27.012987012987, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17562446, Length=325, Percent_Identity=27.3846153846154, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17531909, Length=250, Percent_Identity=26, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531913, Length=201, Percent_Identity=23.8805970149254, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=314, Percent_Identity=25.4777070063694, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=314, Percent_Identity=25.4777070063694, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=35.656836461126, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=33.9622641509434, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=35.0923482849604, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24666513, Length=381, Percent_Identity=31.758530183727, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=29.7650130548303, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI281363737, Length=283, Percent_Identity=36.3957597173145, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI19920834, Length=396, Percent_Identity=28.2828282828283, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 44376; Mature: 44376

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFPFKSLEDFKVEITQDHELLRSAVRDFAENILAKYVERGEKELDIPLEVKQKAKEIGL
CCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCH
YGLFARQDLGGQGADYLSLLTATEEMARIWPSFSTFLLINWMFIYALSRFGNEELKKKYV
HEEEHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHC
TPVANGDKVAAFAVTEPVAGSDVAGIKTTAKKLDSEYVINGRKIFITNGDIADYYLIAAR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEEC
TSPPDPKARWKGISMLVVEKDAVKPVSRIETTGLKSSHTAEILLEDVKTPAENLLGEEGN
CCCCCCHHHHCCCEEEEEECHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHCCCCCC
GFKYAVSSFDFARTIVASQALGIGQAALEKMINYSLQRTAFEKKLAEFQLVQTKVSESLA
CEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLEVARLITYWAGTLFKNGKENEYTVAASLAKFISTESAERIILRAMSVYGGYGVTTSTG
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
LERMLRDLQIMKTYEGTNDIQRISAARFLYNKFIGYKV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVFPFKSLEDFKVEITQDHELLRSAVRDFAENILAKYVERGEKELDIPLEVKQKAKEIGL
CCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCH
YGLFARQDLGGQGADYLSLLTATEEMARIWPSFSTFLLINWMFIYALSRFGNEELKKKYV
HEEEHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHC
TPVANGDKVAAFAVTEPVAGSDVAGIKTTAKKLDSEYVINGRKIFITNGDIADYYLIAAR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEEC
TSPPDPKARWKGISMLVVEKDAVKPVSRIETTGLKSSHTAEILLEDVKTPAENLLGEEGN
CCCCCCHHHHCCCEEEEEECHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHCCCCCC
GFKYAVSSFDFARTIVASQALGIGQAALEKMINYSLQRTAFEKKLAEFQLVQTKVSESLA
CEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLEVARLITYWAGTLFKNGKENEYTVAASLAKFISTESAERIILRAMSVYGGYGVTTSTG
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
LERMLRDLQIMKTYEGTNDIQRISAARFLYNKFIGYKV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]