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The map label for this gene is livH [H]

Identifier: 227828702

GI number: 227828702

Start: 2284481

End: 2285401

Strand: Direct

Name: livH [H]

Synonym: M1425_2460

Alternate gene names: 227828702

Gene position: 2284481-2285401 (Clockwise)

Preceding gene: 227828701

Following gene: 227828703

Centisome position: 87.57

GC content: 37.79

Gene sequence:

>921_bases
ATGATAGATCCCTTAATTATAAATACAATAGTCTACGGTTCAATTCTTGGTTTATCGAGTCTCTCCCTAACTTTAACTTA
CCTAACAACTAAGATACCTAATTTCGCTCACGGTATCTTTCTGTTATTTGGCTCTTATATGACCTTTACCATAGCCGAGG
TCTTAAAACAGAATCCATATTTCTCATTACCTATTGCATTCTTATTAGGTGGGGCAATAGCGTTAATCCAATACTATGGA
GTATTGTTACCCCTAAGTATGAGAGGAGGTGGTTTAGTGTCACAAATGGTTGCTACTCTAGCCTTTTCCATATTACTATA
TGGAGGGCTAAACGCATATGCAAGCTATCTTGGCTATGTATACAATGTGCAATCTAGGGATGTAACCTTGGGATTCTTAG
ACTATGAATTATGGGGAGGAATTAGAGCTGTTTTCCTAGTTTCCATCATTTTAGCGATAGCGTTTATACTCTCGCTTTAC
CTCTTTTTGAATAAGACTAGATTAGGCATATCCATTAGGGCTACAGTTGAAAACTCGTCATTGGCTGAAAGCATGGGTAT
AAATACGAAACTAGTTAAGGCAATTTCTTGGTTTTTGGCTGGAGGTATAGCAAGTGCTGCCGGCTCCTTATATCCTTTAC
AATTCGTATTTTCACCCACACTTGCATATTCAATATTACTAAGCATATTCGCAGCAAGTGTACTAGGAGGTTTAATGAGC
CTATTTGGCGGATTTATAGGCGGATTTATAGAGGGATTCATTGAGAAATACATAATGGCTGAATTATCGATCTATTTATC
CCCAGTAATAGGAGTGAGTCCTTTCGTTATCAACCAATACTCAACGTTAGTACCACTCATAGTAGTTGCAGCAGTTCTCT
TAATAGCGCCAAATGGGATTATGGGAATAAGGGTGAAATAA

Upstream 100 bases:

>100_bases
GTTCACAAGTGGAAGGGTTCTTTTTAAAGGTAAACCATCAGAACTTTTGTCAAATCCCGAGTTAGGAAAAATCTTCTTAG
GTTTAGGGGTGTAAGTCAAA

Downstream 100 bases:

>100_bases
TGGCAGTAGATATTTCCTCTCTTATTTTAGCCATAGTCTTAGACTTCTCAGTATATTTGATGGTTGTAATATCATTAAAT
GTAGAAATAGGATTAACTGG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIDPLIINTIVYGSILGLSSLSLTLTYLTTKIPNFAHGIFLLFGSYMTFTIAEVLKQNPYFSLPIAFLLGGAIALIQYYG
VLLPLSMRGGGLVSQMVATLAFSILLYGGLNAYASYLGYVYNVQSRDVTLGFLDYELWGGIRAVFLVSIILAIAFILSLY
LFLNKTRLGISIRATVENSSLAESMGINTKLVKAISWFLAGGIASAAGSLYPLQFVFSPTLAYSILLSIFAASVLGGLMS
LFGGFIGGFIEGFIEKYIMAELSIYLSPVIGVSPFVINQYSTLVPLIVVAAVLLIAPNGIMGIRVK

Sequences:

>Translated_306_residues
MIDPLIINTIVYGSILGLSSLSLTLTYLTTKIPNFAHGIFLLFGSYMTFTIAEVLKQNPYFSLPIAFLLGGAIALIQYYG
VLLPLSMRGGGLVSQMVATLAFSILLYGGLNAYASYLGYVYNVQSRDVTLGFLDYELWGGIRAVFLVSIILAIAFILSLY
LFLNKTRLGISIRATVENSSLAESMGINTKLVKAISWFLAGGIASAAGSLYPLQFVFSPTLAYSILLSIFAASVLGGLMS
LFGGFIGGFIEGFIEKYIMAELSIYLSPVIGVSPFVINQYSTLVPLIVVAAVLLIAPNGIMGIRVK
>Mature_306_residues
MIDPLIINTIVYGSILGLSSLSLTLTYLTTKIPNFAHGIFLLFGSYMTFTIAEVLKQNPYFSLPIAFLLGGAIALIQYYG
VLLPLSMRGGGLVSQMVATLAFSILLYGGLNAYASYLGYVYNVQSRDVTLGFLDYELWGGIRAVFLVSIILAIAFILSLY
LFLNKTRLGISIRATVENSSLAESMGINTKLVKAISWFLAGGIASAAGSLYPLQFVFSPTLAYSILLSIFAASVLGGLMS
LFGGFIGGFIEGFIEKYIMAELSIYLSPVIGVSPFVINQYSTLVPLIVVAAVLLIAPNGIMGIRVK

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=314, Percent_Identity=29.6178343949045, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32877; Mature: 32877

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPLIINTIVYGSILGLSSLSLTLTYLTTKIPNFAHGIFLLFGSYMTFTIAEVLKQNPY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
FSLPIAFLLGGAIALIQYYGVLLPLSMRGGGLVSQMVATLAFSILLYGGLNAYASYLGYV
CCCHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
YNVQSRDVTLGFLDYELWGGIRAVFLVSIILAIAFILSLYLFLNKTRLGISIRATVENSS
EEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCEEEEEEECCHH
LAESMGINTKLVKAISWFLAGGIASAAGSLYPLQFVFSPTLAYSILLSIFAASVLGGLMS
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGGFIGGFIEGFIEKYIMAELSIYLSPVIGVSPFVINQYSTLVPLIVVAAVLLIAPNGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
MGIRVK
EEEEEC
>Mature Secondary Structure
MIDPLIINTIVYGSILGLSSLSLTLTYLTTKIPNFAHGIFLLFGSYMTFTIAEVLKQNPY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
FSLPIAFLLGGAIALIQYYGVLLPLSMRGGGLVSQMVATLAFSILLYGGLNAYASYLGYV
CCCHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
YNVQSRDVTLGFLDYELWGGIRAVFLVSIILAIAFILSLYLFLNKTRLGISIRATVENSS
EEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCEEEEEEECCHH
LAESMGINTKLVKAISWFLAGGIASAAGSLYPLQFVFSPTLAYSILLSIFAASVLGGLMS
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGGFIGGFIEGFIEKYIMAELSIYLSPVIGVSPFVINQYSTLVPLIVVAAVLLIAPNGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
MGIRVK
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]