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The map label for this gene is thsC [H]

Identifier: 227828602

GI number: 227828602

Start: 2186400

End: 2188007

Strand: Direct

Name: thsC [H]

Synonym: M1425_2355

Alternate gene names: 227828602

Gene position: 2186400-2188007 (Clockwise)

Preceding gene: 227828601

Following gene: 227828603

Centisome position: 83.81

GC content: 38.5

Gene sequence:

>1608_bases
ATGGCCTATTTATTAAGAGAAGGAACACAAAGATCTACTGGAAACGAGGTAATACTAAACAACATAACTGTAGCCAAAAT
ATTACTGGAAATGCTAAAGTCAAGCCTAGGTCCTAAGGGTTTAGACAAAATGTTGGTGGAAGGACAAGACGTTACAATAA
CCAATGACGGTGCAACAATAGTCAAAAACATGGAAGTGCAGCATCCTACTGCAAAATTACTTATTGAAACCGCTAAAACT
GTTGATACCGAGGTAGGAGATGGGACAACTTCAGTAGTTGTTCTTGCCGGGTTACTATTAGAAAAAGCTGAGGATTTACT
GAATCAGAAGATCCATCCAACTGCCATAATAGAAGGTTATAGGAAGGCTCTAAATTCGTCATTAGACTTGCTAAAAAGTA
TTGCAGATAAGATCAGTCCAGAGGATAGGAAGATAATTCATGATCTAGTATATACTACTCTATCAAGTAAGTTCTTCTCG
ACGGAACACACTCTAGAGAAGATAATAAATCTAGTTATTGAAGCTTCATTGGCGGTATTGGATAAAAGAGATGGAACCTA
TGATCTGGATATTAAGAATATAAAGATTGTAAAAGTTAATGGTGGGGAATTTGACGATAGTGAGCTTGTAAATGGGATCG
TTGTAGATAAGGAACCAACTAATGAGAATATGCCGAGAAGATTGGAAAAAGTTAAGGTAATGTTAGCTGACTTTCCATTA
AAACTTGAAAAAACAGAAATTAGTATGAAGCTGGGAATAACTGACCCCACTCAGATAAAGGGATACTTGGATGAACAAAC
GGCATATGTTAAGCAAATGGTGGATAAGATAAAGGCTATGGGCGTTAAATTGTTTATTACACAGAAGGACATTGATGAAG
TCGCTTCATATTTAATGGGAAAAAGTGGGATAATAGCGTTAAAGAACGTAAAGAGGAGCGACATAGAGTTACTGAGTAGA
GCAACTGGTGCGAAAATTGCAAGTAGCATGAAAGACGCTAATGAGAGTGATTTAGGAGAAGCTAAATTAGTGGAGGTTAG
AAATTTAGGAAAGAACAAATACCTCTTCATTCAATCTGATAAAGCTAAAGCGGTGACTGTAATCATAAAGGGCTCGAATA
ACATGGTAACTGATGAAGCAGAAAGGAGTTTAAATGACGCCTTTAACTCCATAAGAAACTTGTTACTAGAACCCTATATT
GTGGCTGGCGGCGGTGCTGTAGAGGAGGAGTTGGCTAAGAGGTTAAGGGAGAACGCTGGAAAGGTTCCCGGAAAAGAGCA
ATTGGCATTTAATGCATTTGCAGATGCTTTGGAGGAGTACGTTTCAATACTATCAGAAACTGCTGGCATGGATCCCATAA
GTGCGTTAACCGAAATAAGGCATAAACACGCAAACGGATTAAAGAATGCTGGGATTGACATAGTTAAGGCCAGAATTTAC
GATAACATGCTCGAGCTTAAAGTAATTGATTCCCTAAAGGTTAAGGATCAAGTTTTAAAGAGCGCCACGGAAGCTGCTAC
TGCGATTTTAAAGATCGATGATATGATAGCTGCAGCACCTGCAAAGCAACAACCCCAACCACAACAACCAAATCCATACC
TAGGTTAA

Upstream 100 bases:

>100_bases
ATTTTAACTCAACACTATTTTTATTCTACTGTTCAGATCCTTAGATAAAACACAAACTTTATACTTTTCTAAACATAGTA
GAGTCGGAGTGAAAGAAAAC

Downstream 100 bases:

>100_bases
AAGGTTAAGATATGATTATTTTATTTAGGTTTTCTTTATTACTTTATGGAACTAAAAATCACTGATTTCAAAGTTTTCGT
AGCTCAAGCCAATTTCGAAT

Product: thermosome

Products: NA

Alternate protein names: Chaperonin subunit gamma; HSP60 gamma subunit; Thermophilic factor 55 gamma; TF55-gamma; Thermosome subunit 3 [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MAYLLREGTQRSTGNEVILNNITVAKILLEMLKSSLGPKGLDKMLVEGQDVTITNDGATIVKNMEVQHPTAKLLIETAKT
VDTEVGDGTTSVVVLAGLLLEKAEDLLNQKIHPTAIIEGYRKALNSSLDLLKSIADKISPEDRKIIHDLVYTTLSSKFFS
TEHTLEKIINLVIEASLAVLDKRDGTYDLDIKNIKIVKVNGGEFDDSELVNGIVVDKEPTNENMPRRLEKVKVMLADFPL
KLEKTEISMKLGITDPTQIKGYLDEQTAYVKQMVDKIKAMGVKLFITQKDIDEVASYLMGKSGIIALKNVKRSDIELLSR
ATGAKIASSMKDANESDLGEAKLVEVRNLGKNKYLFIQSDKAKAVTVIIKGSNNMVTDEAERSLNDAFNSIRNLLLEPYI
VAGGGAVEEELAKRLRENAGKVPGKEQLAFNAFADALEEYVSILSETAGMDPISALTEIRHKHANGLKNAGIDIVKARIY
DNMLELKVIDSLKVKDQVLKSATEAATAILKIDDMIAAAPAKQQPQPQQPNPYLG

Sequences:

>Translated_535_residues
MAYLLREGTQRSTGNEVILNNITVAKILLEMLKSSLGPKGLDKMLVEGQDVTITNDGATIVKNMEVQHPTAKLLIETAKT
VDTEVGDGTTSVVVLAGLLLEKAEDLLNQKIHPTAIIEGYRKALNSSLDLLKSIADKISPEDRKIIHDLVYTTLSSKFFS
TEHTLEKIINLVIEASLAVLDKRDGTYDLDIKNIKIVKVNGGEFDDSELVNGIVVDKEPTNENMPRRLEKVKVMLADFPL
KLEKTEISMKLGITDPTQIKGYLDEQTAYVKQMVDKIKAMGVKLFITQKDIDEVASYLMGKSGIIALKNVKRSDIELLSR
ATGAKIASSMKDANESDLGEAKLVEVRNLGKNKYLFIQSDKAKAVTVIIKGSNNMVTDEAERSLNDAFNSIRNLLLEPYI
VAGGGAVEEELAKRLRENAGKVPGKEQLAFNAFADALEEYVSILSETAGMDPISALTEIRHKHANGLKNAGIDIVKARIY
DNMLELKVIDSLKVKDQVLKSATEAATAILKIDDMIAAAPAKQQPQPQQPNPYLG
>Mature_534_residues
AYLLREGTQRSTGNEVILNNITVAKILLEMLKSSLGPKGLDKMLVEGQDVTITNDGATIVKNMEVQHPTAKLLIETAKTV
DTEVGDGTTSVVVLAGLLLEKAEDLLNQKIHPTAIIEGYRKALNSSLDLLKSIADKISPEDRKIIHDLVYTTLSSKFFST
EHTLEKIINLVIEASLAVLDKRDGTYDLDIKNIKIVKVNGGEFDDSELVNGIVVDKEPTNENMPRRLEKVKVMLADFPLK
LEKTEISMKLGITDPTQIKGYLDEQTAYVKQMVDKIKAMGVKLFITQKDIDEVASYLMGKSGIIALKNVKRSDIELLSRA
TGAKIASSMKDANESDLGEAKLVEVRNLGKNKYLFIQSDKAKAVTVIIKGSNNMVTDEAERSLNDAFNSIRNLLLEPYIV
AGGGAVEEELAKRLRENAGKVPGKEQLAFNAFADALEEYVSILSETAGMDPISALTEIRHKHANGLKNAGIDIVKARIYD
NMLELKVIDSLKVKDQVLKSATEAATAILKIDDMIAAAPAKQQPQPQQPNPYLG

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI38455427, Length=510, Percent_Identity=40, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI24307939, Length=512, Percent_Identity=37.890625, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI63162572, Length=531, Percent_Identity=33.3333333333333, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI5453607, Length=524, Percent_Identity=33.0152671755725, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI5453603, Length=504, Percent_Identity=35.515873015873, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI57863257, Length=529, Percent_Identity=33.8374291115312, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI58761484, Length=470, Percent_Identity=33.1914893617021, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI261399877, Length=487, Percent_Identity=32.6488706365503, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI58331173, Length=519, Percent_Identity=30.8285163776493, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI4502643, Length=513, Percent_Identity=30.9941520467836, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI302058290, Length=512, Percent_Identity=30.078125, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI261399875, Length=442, Percent_Identity=30.7692307692308, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI48762932, Length=534, Percent_Identity=28.0898876404494, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI302058292, Length=519, Percent_Identity=26.9749518304432, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI58331171, Length=513, Percent_Identity=27.2904483430799, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI57863259, Length=368, Percent_Identity=29.0760869565217, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI7657253, Length=518, Percent_Identity=24.7104247104247, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI58331185, Length=315, Percent_Identity=29.8412698412698, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI25914754, Length=475, Percent_Identity=22.7368421052632, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI9055272, Length=475, Percent_Identity=22.7368421052632, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144674, Length=515, Percent_Identity=39.6116504854369, Blast_Score=324, Evalue=9e-89,
Organism=Caenorhabditis elegans, GI17532603, Length=508, Percent_Identity=36.8110236220472, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI25148561, Length=539, Percent_Identity=33.3951762523191, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI25147750, Length=534, Percent_Identity=34.8314606741573, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17532601, Length=536, Percent_Identity=34.5149253731343, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17564182, Length=520, Percent_Identity=31.5384615384615, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI25144678, Length=526, Percent_Identity=30.2281368821293, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566944, Length=442, Percent_Identity=30.5429864253394, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI71998178, Length=566, Percent_Identity=28.6219081272085, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI25144680, Length=413, Percent_Identity=30.5084745762712, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71981457, Length=319, Percent_Identity=37.6175548589342, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322446, Length=520, Percent_Identity=32.8846153846154, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6320058, Length=511, Percent_Identity=35.2250489236791, Blast_Score=283, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6322524, Length=522, Percent_Identity=33.5249042145594, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6322049, Length=507, Percent_Identity=34.5167652859961, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6320418, Length=550, Percent_Identity=31.6363636363636, Blast_Score=255, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6322350, Length=521, Percent_Identity=32.6295585412668, Blast_Score=253, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6322452, Length=557, Percent_Identity=26.9299820466786, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320393, Length=532, Percent_Identity=27.6315789473684, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6321131, Length=172, Percent_Identity=27.3255813953488, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583944, Length=514, Percent_Identity=37.7431906614786, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI17647245, Length=519, Percent_Identity=36.4161849710983, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24647512, Length=536, Percent_Identity=33.3955223880597, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24647510, Length=536, Percent_Identity=33.3955223880597, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24652903, Length=508, Percent_Identity=36.6141732283465, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI28571140, Length=505, Percent_Identity=34.4554455445545, Blast_Score=274, Evalue=9e-74,
Organism=Drosophila melanogaster, GI18858175, Length=505, Percent_Identity=34.2574257425743, Blast_Score=274, Evalue=9e-74,
Organism=Drosophila melanogaster, GI24649027, Length=532, Percent_Identity=34.5864661654135, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24649029, Length=532, Percent_Identity=34.5864661654135, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24645179, Length=527, Percent_Identity=32.258064516129, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19921848, Length=527, Percent_Identity=29.9810246679317, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI18859933, Length=511, Percent_Identity=29.3542074363992, Blast_Score=198, Evalue=7e-51,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58638; Mature: 58506

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00750 TCP1_1 ; PS00751 TCP1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYLLREGTQRSTGNEVILNNITVAKILLEMLKSSLGPKGLDKMLVEGQDVTITNDGATI
CCCHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCCEE
VKNMEVQHPTAKLLIETAKTVDTEVGDGTTSVVVLAGLLLEKAEDLLNQKIHPTAIIEGY
EECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RKALNSSLDLLKSIADKISPEDRKIIHDLVYTTLSSKFFSTEHTLEKIINLVIEASLAVL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKRDGTYDLDIKNIKIVKVNGGEFDDSELVNGIVVDKEPTNENMPRRLEKVKVMLADFPL
CCCCCEEEEEECEEEEEEECCCCCCHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCCC
KLEKTEISMKLGITDPTQIKGYLDEQTAYVKQMVDKIKAMGVKLFITQKDIDEVASYLMG
EEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCC
KSGIIALKNVKRSDIELLSRATGAKIASSMKDANESDLGEAKLVEVRNLGKNKYLFIQSD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECC
KAKAVTVIIKGSNNMVTDEAERSLNDAFNSIRNLLLEPYIVAGGGAVEEELAKRLRENAG
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCC
KVPGKEQLAFNAFADALEEYVSILSETAGMDPISALTEIRHKHANGLKNAGIDIVKARIY
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DNMLELKVIDSLKVKDQVLKSATEAATAILKIDDMIAAAPAKQQPQPQQPNPYLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AYLLREGTQRSTGNEVILNNITVAKILLEMLKSSLGPKGLDKMLVEGQDVTITNDGATI
CCHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCCEE
VKNMEVQHPTAKLLIETAKTVDTEVGDGTTSVVVLAGLLLEKAEDLLNQKIHPTAIIEGY
EECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RKALNSSLDLLKSIADKISPEDRKIIHDLVYTTLSSKFFSTEHTLEKIINLVIEASLAVL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKRDGTYDLDIKNIKIVKVNGGEFDDSELVNGIVVDKEPTNENMPRRLEKVKVMLADFPL
CCCCCEEEEEECEEEEEEECCCCCCHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCCC
KLEKTEISMKLGITDPTQIKGYLDEQTAYVKQMVDKIKAMGVKLFITQKDIDEVASYLMG
EEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCC
KSGIIALKNVKRSDIELLSRATGAKIASSMKDANESDLGEAKLVEVRNLGKNKYLFIQSD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECC
KAKAVTVIIKGSNNMVTDEAERSLNDAFNSIRNLLLEPYIVAGGGAVEEELAKRLRENAG
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCC
KVPGKEQLAFNAFADALEEYVSILSETAGMDPISALTEIRHKHANGLKNAGIDIVKARIY
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DNMLELKVIDSLKVKDQVLKSATEAATAILKIDDMIAAAPAKQQPQPQQPNPYLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10508614 [H]