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The map label for this gene is fadE12 [H]

Identifier: 227828474

GI number: 227828474

Start: 2031312

End: 2032481

Strand: Direct

Name: fadE12 [H]

Synonym: M1425_2222

Alternate gene names: 227828474

Gene position: 2031312-2032481 (Clockwise)

Preceding gene: 227828473

Following gene: 227828476

Centisome position: 77.86

GC content: 36.24

Gene sequence:

>1170_bases
ATGTTATTGCAAACAAAAGATGAAGAAGAGAAATTGATCCTCTCAACAGTTGACCAATTGATGAAAAAATACGATGAGAA
ATATTGGTTGGATAAAGATCAAAAGAGGGAATTTCCAATAGATTTCCTCAACGACTTCATAAAATTAGGATTAGGGTCAA
TTTTAATGCCAGAAGAATATGGTGGGATAGGGAAAGGGGTTAAACTAGCTTGTCTAATCCTCTATACTCTCAATCTAAGG
GGTGGTAATTCGTATTTTGTACATGGACACTACTACAACACTGCGCTACTATCAAAACACGCTGGTAAAAGAGTAAGAGA
TAAATACTTCAAGGATATTACAAATGGCGCTAAAGTATTATCATTAGCCCTAACTGAACCAGAAGTGGGGTCAGATACAA
CAAAGATTAAGACAGTTGCAGATAAAGTTGGAAATAATTTCGTTATAAAGGGTCACAAGATATTCATTTCTAGGGTAAAA
CACACTGACTTTATGATATTGGTAGCTAGGACAACACCTTATGACAAGGTTGAAAAGAAGACCGATGGCATAACCTTGTT
TTTAGTTGATCTAAGAGAGGCAAGGGAAGGAATTGAGATGAGGGAAATAAAGACCATGTCAAATACTAATGCTTACGAAA
TGTTTATAGACGGTCTTAAAGTGCCAGAGAATAACGTTATAGGAGAAGTTGGAAGGGGATTCTATTACTTGCTTGACCTA
TTAAATGCTGAGAGATTTATGATAGCTGCAGAAATGATAGGTAACGCAGAGTGGTTCATAAATAAGGCTGTGGAATACGC
TAATAATAGAGTAGTTTTTGATAAGCAAATAGGTAGCTTCCAAGGTGTACAATTTCCAATAGCTAAAGTGTATGCTCAAT
TAGTATCCCTCTCCTCTTACTTTAGTGAAGGTTTGAGAGCACTAGAAGAAGGGAAGGATACAAAAACCATCGGAAATTAC
GCAAACGTATCAAAATATCTGGCAGCTGAAATAGCTTGGGAGGCTGGAAATGTGGCAATGGACGTTTATGGAGGTTACGG
ATATGCTGTAGAAACTGGAATAGAAAGGAAACTTAGAGAGACTAGATTATATAAGGTAGCCCCAATATCACAAAATTTAG
TATTAGCATACATTTCTCATCATATATTGGGTCTTCCTAAATCATATTAG

Upstream 100 bases:

>100_bases
ATTTTGCAGAGTTTTATAGGAGGTTATATTGGGAAATTACCAATTCCGGTTGAAATTTAATGGAAAATCTATATAAACAA
GTTAATTACCTTTTATTTGT

Downstream 100 bases:

>100_bases
TATTTATTATTCCTTTTTCAGCAAGCTTTTTTATATCCTCTTCCGAATATCCTAACTCAAGTAAAACTTCTTTAGTATTC
TCACCGAGTTTAGGTGCTTT

Product: acyl-CoA dehydrogenase domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MLLQTKDEEEKLILSTVDQLMKKYDEKYWLDKDQKREFPIDFLNDFIKLGLGSILMPEEYGGIGKGVKLACLILYTLNLR
GGNSYFVHGHYYNTALLSKHAGKRVRDKYFKDITNGAKVLSLALTEPEVGSDTTKIKTVADKVGNNFVIKGHKIFISRVK
HTDFMILVARTTPYDKVEKKTDGITLFLVDLREAREGIEMREIKTMSNTNAYEMFIDGLKVPENNVIGEVGRGFYYLLDL
LNAERFMIAAEMIGNAEWFINKAVEYANNRVVFDKQIGSFQGVQFPIAKVYAQLVSLSSYFSEGLRALEEGKDTKTIGNY
ANVSKYLAAEIAWEAGNVAMDVYGGYGYAVETGIERKLRETRLYKVAPISQNLVLAYISHHILGLPKSY

Sequences:

>Translated_389_residues
MLLQTKDEEEKLILSTVDQLMKKYDEKYWLDKDQKREFPIDFLNDFIKLGLGSILMPEEYGGIGKGVKLACLILYTLNLR
GGNSYFVHGHYYNTALLSKHAGKRVRDKYFKDITNGAKVLSLALTEPEVGSDTTKIKTVADKVGNNFVIKGHKIFISRVK
HTDFMILVARTTPYDKVEKKTDGITLFLVDLREAREGIEMREIKTMSNTNAYEMFIDGLKVPENNVIGEVGRGFYYLLDL
LNAERFMIAAEMIGNAEWFINKAVEYANNRVVFDKQIGSFQGVQFPIAKVYAQLVSLSSYFSEGLRALEEGKDTKTIGNY
ANVSKYLAAEIAWEAGNVAMDVYGGYGYAVETGIERKLRETRLYKVAPISQNLVLAYISHHILGLPKSY
>Mature_389_residues
MLLQTKDEEEKLILSTVDQLMKKYDEKYWLDKDQKREFPIDFLNDFIKLGLGSILMPEEYGGIGKGVKLACLILYTLNLR
GGNSYFVHGHYYNTALLSKHAGKRVRDKYFKDITNGAKVLSLALTEPEVGSDTTKIKTVADKVGNNFVIKGHKIFISRVK
HTDFMILVARTTPYDKVEKKTDGITLFLVDLREAREGIEMREIKTMSNTNAYEMFIDGLKVPENNVIGEVGRGFYYLLDL
LNAERFMIAAEMIGNAEWFINKAVEYANNRVVFDKQIGSFQGVQFPIAKVYAQLVSLSSYFSEGLRALEEGKDTKTIGNY
ANVSKYLAAEIAWEAGNVAMDVYGGYGYAVETGIERKLRETRLYKVAPISQNLVLAYISHHILGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=384, Percent_Identity=29.4270833333333, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI226958412, Length=368, Percent_Identity=25.8152173913043, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=27.1137026239067, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557235, Length=279, Percent_Identity=29.7491039426523, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI76496475, Length=279, Percent_Identity=29.7491039426523, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557231, Length=363, Percent_Identity=26.1707988980716, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI187960098, Length=363, Percent_Identity=26.1707988980716, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4501857, Length=325, Percent_Identity=27.0769230769231, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI7656849, Length=361, Percent_Identity=26.5927977839335, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI21361497, Length=356, Percent_Identity=26.123595505618, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI4557233, Length=388, Percent_Identity=27.0618556701031, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI87081958, Length=379, Percent_Identity=25.5936675461741, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=26.7015706806283, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71985184, Length=392, Percent_Identity=27.0408163265306, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17538396, Length=368, Percent_Identity=27.445652173913, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17508101, Length=380, Percent_Identity=27.1052631578947, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17534899, Length=347, Percent_Identity=27.9538904899135, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=365, Percent_Identity=24.6575342465753, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=25.3333333333333, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17569725, Length=358, Percent_Identity=26.8156424581006, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17570075, Length=361, Percent_Identity=25.207756232687, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17505929, Length=325, Percent_Identity=25.2307692307692, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17506239, Length=344, Percent_Identity=25, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71990804, Length=266, Percent_Identity=28.9473684210526, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71985192, Length=309, Percent_Identity=26.537216828479, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71982178, Length=284, Percent_Identity=27.112676056338, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563615, Length=253, Percent_Identity=26.4822134387352, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531909, Length=250, Percent_Identity=24.4, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355753, Length=331, Percent_Identity=29.3051359516616, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281363737, Length=350, Percent_Identity=27.7142857142857, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=27.3684210526316, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356377, Length=346, Percent_Identity=27.1676300578035, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24660351, Length=348, Percent_Identity=26.1494252873563, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646207, Length=350, Percent_Identity=27.7142857142857, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 44040; Mature: 44040

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLQTKDEEEKLILSTVDQLMKKYDEKYWLDKDQKREFPIDFLNDFIKLGLGSILMPEEY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEECCHHC
GGIGKGVKLACLILYTLNLRGGNSYFVHGHYYNTALLSKHAGKRVRDKYFKDITNGAKVL
CCCCCCHHHHEEEEEEEEECCCCEEEEEEEEECHHHHHHHCCHHHHHHHHHHHCCCCEEE
SLALTEPEVGSDTTKIKTVADKVGNNFVIKGHKIFISRVKHTDFMILVARTTPYDKVEKK
EEEECCCCCCCCHHHHHHHHHHHCCEEEEECCEEEEEEECCCCEEEEEEECCCHHHHHHC
TDGITLFLVDLREAREGIEMREIKTMSNTNAYEMFIDGLKVPENNVIGEVGRGFYYLLDL
CCCEEEEEEEHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCHHHHHHHH
LNAERFMIAAEMIGNAEWFINKAVEYANNRVVFDKQIGSFQGVQFPIAKVYAQLVSLSSY
HCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
FSEGLRALEEGKDTKTIGNYANVSKYLAAEIAWEAGNVAMDVYGGYGYAVETGIERKLRE
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEHHHHHHHHHH
TRLYKVAPISQNLVLAYISHHILGLPKSY
HHCEEECCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLLQTKDEEEKLILSTVDQLMKKYDEKYWLDKDQKREFPIDFLNDFIKLGLGSILMPEEY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEECCHHC
GGIGKGVKLACLILYTLNLRGGNSYFVHGHYYNTALLSKHAGKRVRDKYFKDITNGAKVL
CCCCCCHHHHEEEEEEEEECCCCEEEEEEEEECHHHHHHHCCHHHHHHHHHHHCCCCEEE
SLALTEPEVGSDTTKIKTVADKVGNNFVIKGHKIFISRVKHTDFMILVARTTPYDKVEKK
EEEECCCCCCCCHHHHHHHHHHHCCEEEEECCEEEEEEECCCCEEEEEEECCCHHHHHHC
TDGITLFLVDLREAREGIEMREIKTMSNTNAYEMFIDGLKVPENNVIGEVGRGFYYLLDL
CCCEEEEEEEHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCHHHHHHHH
LNAERFMIAAEMIGNAEWFINKAVEYANNRVVFDKQIGSFQGVQFPIAKVYAQLVSLSSY
HCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
FSEGLRALEEGKDTKTIGNYANVSKYLAAEIAWEAGNVAMDVYGGYGYAVETGIERKLRE
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEHHHHHHHHHH
TRLYKVAPISQNLVLAYISHHILGLPKSY
HHCEEECCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]