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The map label for this gene is gds [H]

Identifier: 227828317

GI number: 227828317

Start: 1886089

End: 1887084

Strand: Direct

Name: gds [H]

Synonym: M1425_2058

Alternate gene names: 227828317

Gene position: 1886089-1887084 (Clockwise)

Preceding gene: 227828316

Following gene: 227828318

Centisome position: 72.3

GC content: 34.94

Gene sequence:

>996_bases
ATGAGTGACGAATTAAGTTCGTATTTTAATGATATAGTTAACAATGTAAATTTTCATATAAAAAATTTTGTAAAGAGCAA
TGTTAGAACGCTTGAGGAAGCATCATTTCATTTATTTACAGCTGGGGGCAAAAGACTTAGACCCTTAATTCTGGTTTCAT
CGTCAGACTTAATTGGCGGGGACAGGCAAAGGGCATATAAGGCAGCAGCTGCCGTGGAGATTCTTCACAACTTTACTCTA
GTTCATGACGACATAATGGATAGGGATTACCTTAGAAGAGGATTACCAACTGTTCATGTAAAGTGGGGTGAACCAATGGC
AATACTTGCAGGGGATTACTTACACGCTAAGGCTTTTGAAGCCTTAAATGAGGCTCTAAAAGGTCTTGACGGGGATACGT
TTTATAAGGCTTTTTCCATATTTATTAATTCTATCGAGATAATATCGGAAGGTCAAGCAATGGATATGTCATTTGAAAAT
AGAGTAGATGTAACTGAAGAAGAGTATGTACAAATGATAAAAGGAAAGACTGCAATGTTATTTTCATGCTCTGCAGCATT
AGGCGGTATAATTAACAAGGCTAGCGATGATATAATTAAAAATTTAATTGAATATGGATTAAATTTAGGCATATCATTTC
AAATAGTGGATGATATCTTAGGAATTATTGGAGATGAAAAGGAATTAGGGAAACCAGTTTACAGTGATATTAGGGAAGGT
AAGAAAACAATTCTTGTTATAAAAACTTTAAGTGAAGCTAAAGACGATGAAAAGAAAATTCTGGTTTCTACGCTTGGGAA
TAGGGAGGCTAAAAAGGACGATCTTGAGAGAGCGTCGGAAATAATAAGGAAGTATTCATTGCAATATGCATACAATTTAG
CTAGAAAGTACTCAGATCTTGCATTAGAACACTTGCGTAAAATTCCAGTTTACAATGAAACTGCTGAAAAGGCTTTAAAA
TATCTAGCGCAGTTTACCATTGAAAGGAGAAAGTAA

Upstream 100 bases:

>100_bases
AAGAAGACCAGTATTGTTATTTTAGGTAAACTTAAAGAGTGGGCAGAATATAGGGGGATAAATTTATCTACATACGATAA
AGTTAGAAAGAGAGAATAAA

Downstream 100 bases:

>100_bases
ATGAGCATATCGGGAATATTGCTTTCAATTTTTATATCCTTTTTCATAAGCTATATCACAACAGTCTGGGTAATAAGACA
AGCAAAAAAGAGTGGGCTTG

Product: Farnesyltranstransferase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSDELSSYFNDIVNNVNFHIKNFVKSNVRTLEEASFHLFTAGGKRLRPLILVSSSDLIGGDRQRAYKAAAAVEILHNFTL
VHDDIMDRDYLRRGLPTVHVKWGEPMAILAGDYLHAKAFEALNEALKGLDGDTFYKAFSIFINSIEIISEGQAMDMSFEN
RVDVTEEEYVQMIKGKTAMLFSCSAALGGIINKASDDIIKNLIEYGLNLGISFQIVDDILGIIGDEKELGKPVYSDIREG
KKTILVIKTLSEAKDDEKKILVSTLGNREAKKDDLERASEIIRKYSLQYAYNLARKYSDLALEHLRKIPVYNETAEKALK
YLAQFTIERRK

Sequences:

>Translated_331_residues
MSDELSSYFNDIVNNVNFHIKNFVKSNVRTLEEASFHLFTAGGKRLRPLILVSSSDLIGGDRQRAYKAAAAVEILHNFTL
VHDDIMDRDYLRRGLPTVHVKWGEPMAILAGDYLHAKAFEALNEALKGLDGDTFYKAFSIFINSIEIISEGQAMDMSFEN
RVDVTEEEYVQMIKGKTAMLFSCSAALGGIINKASDDIIKNLIEYGLNLGISFQIVDDILGIIGDEKELGKPVYSDIREG
KKTILVIKTLSEAKDDEKKILVSTLGNREAKKDDLERASEIIRKYSLQYAYNLARKYSDLALEHLRKIPVYNETAEKALK
YLAQFTIERRK
>Mature_330_residues
SDELSSYFNDIVNNVNFHIKNFVKSNVRTLEEASFHLFTAGGKRLRPLILVSSSDLIGGDRQRAYKAAAAVEILHNFTLV
HDDIMDRDYLRRGLPTVHVKWGEPMAILAGDYLHAKAFEALNEALKGLDGDTFYKAFSIFINSIEIISEGQAMDMSFENR
VDVTEEEYVQMIKGKTAMLFSCSAALGGIINKASDDIIKNLIEYGLNLGISFQIVDDILGIIGDEKELGKPVYSDIREGK
KTILVIKTLSEAKDDEKKILVSTLGNREAKKDDLERASEIIRKYSLQYAYNLARKYSDLALEHLRKIPVYNETAEKALKY
LAQFTIERRK

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=311, Percent_Identity=27.9742765273312, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI209571582, Length=249, Percent_Identity=29.718875502008, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4503685, Length=249, Percent_Identity=29.718875502008, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4758430, Length=223, Percent_Identity=28.6995515695067, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI83700220, Length=223, Percent_Identity=28.6995515695067, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI209571584, Length=249, Percent_Identity=29.718875502008, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789578, Length=319, Percent_Identity=29.153605015674, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786623, Length=228, Percent_Identity=34.6491228070175, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17505681, Length=335, Percent_Identity=29.2537313432836, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319475, Length=315, Percent_Identity=28.2539682539683, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6325188, Length=221, Percent_Identity=26.6968325791855, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651612, Length=346, Percent_Identity=24.2774566473988, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137582, Length=305, Percent_Identity=24.9180327868852, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 37388; Mature: 37257

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDELSSYFNDIVNNVNFHIKNFVKSNVRTLEEASFHLFTAGGKRLRPLILVSSSDLIGG
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCCC
DRQRAYKAAAAVEILHNFTLVHDDIMDRDYLRRGLPTVHVKWGEPMAILAGDYLHAKAFE
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEECCCCEEEEECCHHHHHHHH
ALNEALKGLDGDTFYKAFSIFINSIEIISEGQAMDMSFENRVDVTEEEYVQMIKGKTAML
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCCHHHE
FSCSAALGGIINKASDDIIKNLIEYGLNLGISFQIVDDILGIIGDEKELGKPVYSDIREG
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEHHHHHHHCCCCHHHCCHHHHHHHCC
KKTILVIKTLSEAKDDEKKILVSTLGNREAKKDDLERASEIIRKYSLQYAYNLARKYSDL
CCEEEEEEEHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALEHLRKIPVYNETAEKALKYLAQFTIERRK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDELSSYFNDIVNNVNFHIKNFVKSNVRTLEEASFHLFTAGGKRLRPLILVSSSDLIGG
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCCC
DRQRAYKAAAAVEILHNFTLVHDDIMDRDYLRRGLPTVHVKWGEPMAILAGDYLHAKAFE
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEECCCCEEEEECCHHHHHHHH
ALNEALKGLDGDTFYKAFSIFINSIEIISEGQAMDMSFENRVDVTEEEYVQMIKGKTAML
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCCHHHE
FSCSAALGGIINKASDDIIKNLIEYGLNLGISFQIVDDILGIIGDEKELGKPVYSDIREG
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEHHHHHHHCCCCHHHCCHHHHHHHCC
KKTILVIKTLSEAKDDEKKILVSTLGNREAKKDDLERASEIIRKYSLQYAYNLARKYSDL
CCEEEEEEEHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALEHLRKIPVYNETAEKALKYLAQFTIERRK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]