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The map label for this gene is gnpTA [H]

Identifier: 227828318

GI number: 227828318

Start: 1887085

End: 1888053

Strand: Direct

Name: gnpTA [H]

Synonym: M1425_2059

Alternate gene names: 227828318

Gene position: 1887085-1888053 (Clockwise)

Preceding gene: 227828317

Following gene: 227828323

Centisome position: 72.33

GC content: 35.4

Gene sequence:

>969_bases
ATGAGCATATCGGGAATATTGCTTTCAATTTTTATATCCTTTTTCATAAGCTATATCACAACAGTCTGGGTAATAAGACA
AGCAAAAAAGAGTGGGCTTGTAGGTAAGGATGTAAATAAACCAGATAAACCGGAAATACCACTAATGGGTGGGATAAGTA
TAATAGCTGGGTTTATAGCGGGATCCTTCTCCTTATTACTAACTGATGTAAGAAGTGAGAGAGTAATTCCATCTGTAATA
CTCTCCTCATTGCTTATAGCATTTCTTGGGCTATTAGATGATATATTTAACGTTAGGCAATCAGTAAGAGCATTTCTACC
AATTTTCGCATCAGTTCCGCTAATAGTTTACAGCGTTGGACACTCAGTAATATCAATTCCATTTTTAGGTCCGGTAAATT
TCGGAATATTGTATTATGTCATAATAATACCTTTTGCGTTAACGATAACATCTAATGCCTTCAATATGCTAGAGGGTCTA
AACGGGTTGGGTGTAGGTATGGGGATTATAATGTTATCTGCATTAGCGTATATAGGACTAACTCATGGTGGCTCTTCATA
CCAAGCTGGTTTAGTGGCACTTTCAGCAATTTTTTCATTAGTGGCTTTTCTCTTATTTAATAAATATCCTGCGAAAATAT
TTCCAGGTAATGTTGGCACGTATTTCATAGGAGCATTGATAGGAGCCATAGGAATTGCGGGTTTCATGTACACTGCATTA
GCGATTCTCTATATACCATACGTTGTGGAATTCATATTAAAGTTAAGAACAAAGTTTAAGGGCGTATCGTTTGGCAAAGT
TGACTCTTCTGGTAGATTATATTGGGATGAAAAGCCTCATTCATTAACACATATAGTAATGAAAATGGGCCGATTTAAGG
AGTATCAAGTGGTTATAATTTTATGGGGAGTAGAAGCAATATTCGCAATAATAGCTGTAATTCTACAAAGTGTAACAATA
GTAATATAA

Upstream 100 bases:

>100_bases
TCTTGCATTAGAACACTTGCGTAAAATTCCAGTTTACAATGAAACTGCTGAAAAGGCTTTAAAATATCTAGCGCAGTTTA
CCATTGAAAGGAGAAAGTAA

Downstream 100 bases:

>100_bases
CAGAACTCTTGGCATTTATCAATACTCTTAAAAATCATTAAAGATATATATAGATGGGGCCAGGGAGGGTGGGGGATCTC
GCCAATCCCTGTGACCCGCA

Product: glycosyl transferase family 4

Products: NA

Alternate protein names: GlcNAc-1-P transferase; G1PT; GPT; N-acetylglucosamine-1-phosphate transferase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSISGILLSIFISFFISYITTVWVIRQAKKSGLVGKDVNKPDKPEIPLMGGISIIAGFIAGSFSLLLTDVRSERVIPSVI
LSSLLIAFLGLLDDIFNVRQSVRAFLPIFASVPLIVYSVGHSVISIPFLGPVNFGILYYVIIIPFALTITSNAFNMLEGL
NGLGVGMGIIMLSALAYIGLTHGGSSYQAGLVALSAIFSLVAFLLFNKYPAKIFPGNVGTYFIGALIGAIGIAGFMYTAL
AILYIPYVVEFILKLRTKFKGVSFGKVDSSGRLYWDEKPHSLTHIVMKMGRFKEYQVVIILWGVEAIFAIIAVILQSVTI
VI

Sequences:

>Translated_322_residues
MSISGILLSIFISFFISYITTVWVIRQAKKSGLVGKDVNKPDKPEIPLMGGISIIAGFIAGSFSLLLTDVRSERVIPSVI
LSSLLIAFLGLLDDIFNVRQSVRAFLPIFASVPLIVYSVGHSVISIPFLGPVNFGILYYVIIIPFALTITSNAFNMLEGL
NGLGVGMGIIMLSALAYIGLTHGGSSYQAGLVALSAIFSLVAFLLFNKYPAKIFPGNVGTYFIGALIGAIGIAGFMYTAL
AILYIPYVVEFILKLRTKFKGVSFGKVDSSGRLYWDEKPHSLTHIVMKMGRFKEYQVVIILWGVEAIFAIIAVILQSVTI
VI
>Mature_321_residues
SISGILLSIFISFFISYITTVWVIRQAKKSGLVGKDVNKPDKPEIPLMGGISIIAGFIAGSFSLLLTDVRSERVIPSVIL
SSLLIAFLGLLDDIFNVRQSVRAFLPIFASVPLIVYSVGHSVISIPFLGPVNFGILYYVIIIPFALTITSNAFNMLEGLN
GLGVGMGIIMLSALAYIGLTHGGSSYQAGLVALSAIFSLVAFLLFNKYPAKIFPGNVGTYFIGALIGAIGIAGFMYTALA
ILYIPYVVEFILKLRTKFKGVSFGKVDSSGRLYWDEKPHSLTHIVMKMGRFKEYQVVIILWGVEAIFAIIAVILQSVTIV
I

Specific function: Catalyzes The Synthesis Of Und-Pp-Glcnac (Lipid I), The First Lipid-Linked Intermediate Involved In Eca Synthesis. This Lipid Is Also An Acceptor For The Addition Of Subsequent Sugars To Complete The Biosynthesis Of O-Antigen. [C]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family [H]

Homologues:

Organism=Homo sapiens, GI42794009, Length=270, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319720, Length=338, Percent_Identity=28.1065088757396, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921214, Length=318, Percent_Identity=25.7861635220126, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: =2.7.8.15 [H]

Molecular weight: Translated: 34918; Mature: 34787

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISGILLSIFISFFISYITTVWVIRQAKKSGLVGKDVNKPDKPEIPLMGGISIIAGFIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GSFSLLLTDVRSERVIPSVILSSLLIAFLGLLDDIFNVRQSVRAFLPIFASVPLIVYSVG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HSVISIPFLGPVNFGILYYVIIIPFALTITSNAFNMLEGLNGLGVGMGIIMLSALAYIGL
HHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
THGGSSYQAGLVALSAIFSLVAFLLFNKYPAKIFPGNVGTYFIGALIGAIGIAGFMYTAL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AILYIPYVVEFILKLRTKFKGVSFGKVDSSGRLYWDEKPHSLTHIVMKMGRFKEYQVVII
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEEEE
LWGVEAIFAIIAVILQSVTIVI
EECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SISGILLSIFISFFISYITTVWVIRQAKKSGLVGKDVNKPDKPEIPLMGGISIIAGFIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GSFSLLLTDVRSERVIPSVILSSLLIAFLGLLDDIFNVRQSVRAFLPIFASVPLIVYSVG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HSVISIPFLGPVNFGILYYVIIIPFALTITSNAFNMLEGLNGLGVGMGIIMLSALAYIGL
HHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
THGGSSYQAGLVALSAIFSLVAFLLFNKYPAKIFPGNVGTYFIGALIGAIGIAGFMYTAL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AILYIPYVVEFILKLRTKFKGVSFGKVDSSGRLYWDEKPHSLTHIVMKMGRFKEYQVVII
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEEEE
LWGVEAIFAIIAVILQSVTIVI
EECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]