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The map label for this gene is 227828153

Identifier: 227828153

GI number: 227828153

Start: 1731281

End: 1731796

Strand: Direct

Name: 227828153

Synonym: M1425_1891

Alternate gene names: NA

Gene position: 1731281-1731796 (Clockwise)

Preceding gene: 227828152

Following gene: 227828154

Centisome position: 66.36

GC content: 33.53

Gene sequence:

>516_bases
ATGGATATTTTATGGGCACCATGGAGAGCTAAGTATATTTCTGAAACTAGCAAGCTAAAACAAGATGAATGCCTATTTTG
TAGAGTAATAAAAGAAGAAAATGATGAGCAAAATTACGTAGTATATAGGGGAAAATATGCTTTCATAATACTTAATGCAT
TCCCTTATAATACTGCTCATGTAATGGTTGTCCCTTACAAGCATGTCCCTTCAATTGAGCTTTTAAGTAATGATGAGGCA
TTAGATATATTTAATTTAATTAGTGTTGCAATAAAGGCTATAAGAGAAATTTATACCCCAGACGGTTTTAATATAGGTGT
AAATATAGGTAGAGTAGCTGGAGCAGGTATAGAAGCTCACGTTCACGTTCACATCGTGCCAAGATGGAATGGTGATTCCA
ATTTTATGCCAGTTATTTTTAACACTAAGGTTATGCCAGAGACGCTTGGAGATACGTTTAAAAAATTAAATGCAAAAATT
AATGAGATTATGAAGAAGCCCTCGAAATCTGAGTAA

Upstream 100 bases:

>100_bases
ACCAGAAGGAGAAGTAGTGTTTGCGTTAACTGAAGAAGGAATAAGGGACGCGGAAGAGTAAAAGTTAATATTTTATGTAT
CATTGAAGTATATCTTACTT

Downstream 100 bases:

>100_bases
TTGATGAAGGCAGGGTTTTACGGATGAATTATTTAGAATATTTTGATAGAATTAGACTAGCAAAAGAGAAAATAGAAAAA
TATGTACATACTACTCCAAT

Product: histidine triad (HIT) protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MDILWAPWRAKYISETSKLKQDECLFCRVIKEENDEQNYVVYRGKYAFIILNAFPYNTAHVMVVPYKHVPSIELLSNDEA
LDIFNLISVAIKAIREIYTPDGFNIGVNIGRVAGAGIEAHVHVHIVPRWNGDSNFMPVIFNTKVMPETLGDTFKKLNAKI
NEIMKKPSKSE

Sequences:

>Translated_171_residues
MDILWAPWRAKYISETSKLKQDECLFCRVIKEENDEQNYVVYRGKYAFIILNAFPYNTAHVMVVPYKHVPSIELLSNDEA
LDIFNLISVAIKAIREIYTPDGFNIGVNIGRVAGAGIEAHVHVHIVPRWNGDSNFMPVIFNTKVMPETLGDTFKKLNAKI
NEIMKKPSKSE
>Mature_171_residues
MDILWAPWRAKYISETSKLKQDECLFCRVIKEENDEQNYVVYRGKYAFIILNAFPYNTAHVMVVPYKHVPSIELLSNDEA
LDIFNLISVAIKAIREIYTPDGFNIGVNIGRVAGAGIEAHVHVHIVPRWNGDSNFMPVIFNTKVMPETLGDTFKKLNAKI
NEIMKKPSKSE

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 19528; Mature: 19528

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILWAPWRAKYISETSKLKQDECLFCRVIKEENDEQNYVVYRGKYAFIILNAFPYNTAH
CCEEECCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCEEEEEEECCCCCCEE
VMVVPYKHVPSIELLSNDEALDIFNLISVAIKAIREIYTPDGFNIGVNIGRVAGAGIEAH
EEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEECEEECCEECCCEEEE
VHVHIVPRWNGDSNFMPVIFNTKVMPETLGDTFKKLNAKINEIMKKPSKSE
EEEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDILWAPWRAKYISETSKLKQDECLFCRVIKEENDEQNYVVYRGKYAFIILNAFPYNTAH
CCEEECCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCEEEEEEECCCCCCEE
VMVVPYKHVPSIELLSNDEALDIFNLISVAIKAIREIYTPDGFNIGVNIGRVAGAGIEAH
EEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEECEEECCEECCCEEEE
VHVHIVPRWNGDSNFMPVIFNTKVMPETLGDTFKKLNAKINEIMKKPSKSE
EEEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]