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The map label for this gene is tdcB [H]

Identifier: 227828154

GI number: 227828154

Start: 1731820

End: 1733037

Strand: Direct

Name: tdcB [H]

Synonym: M1425_1892

Alternate gene names: 227828154

Gene position: 1731820-1733037 (Clockwise)

Preceding gene: 227828153

Following gene: 227828155

Centisome position: 66.38

GC content: 34.73

Gene sequence:

>1218_bases
ATGAATTATTTAGAATATTTTGATAGAATTAGACTAGCAAAAGAGAAAATAGAAAAATATGTACATACTACTCCAATAGA
CTATTCCACAACATTTTCTAGGATTACAAACGCAAAAGTTTATCTTAAATTAGAAAACTTACAGAAAACGGGATCATTTA
AAGTTAGAGGTGCCTTCAATAAACTGTTATCTCTGAAGGAGGAAGAAAAAAAGAAAGGCGTTATTGCTGTCTCAGCAGGT
AATCACGCTCAAGGAGTTGCATATGCTGCTTCAACGTTGAATATTAGATCAACTATAGTGATGCCAGAAACAGCTCCAGC
TTCTAAGTATTTAGCTACAAGATCCTATGGGGCAGATGTGGTACTATATGGTAAGTACTTGCATGAGAGTATGAAGAAAG
CTGAAGAATTGATTCAAAACACTGGTTTAATATTTGTTCATCCTTATGGCGATTTAGACGTGATAGTAGGGCAGGGTACT
ATAGGATTAGAATTATACGATGTTGAACCAGATTACGTGATTATTCCAATAGGAGGTGGAGGACTAATTTCTGGTATAAG
TATAGCTTTAAAGTATAGATTCCCAAATGTCAAGATAATAGGCGTTCAGTCTTCCTCTTCTCCTTCTATGAAGGTTTCTA
AAGATCTAGGAAGGCTTGTAGAAATAGAGCCCGGCTATTCTATAGCTGACGGCATACTGGTTAAGTATCCTTCTGAATTA
ACCTTTGGTATCATTAATGAGTTAGTAGATGATATAGTATTAGTAGATGATGAAGAAATAGCTGAAGCAATAGTTTTACT
ACTGGAAAGAAGTAAAACATTAGCAGAAGGAGCAGGGGCTGCTGCACTTGCGTCACTAATTTCAGGAAAGGTCAAAGTGA
ATGGAATAGACAAAAAAGTAATTTCACTAGTAAGTGGAGGGAATATTGACCTATCTTTATTGTCTACTCTCACTGAGAAG
TTTTTATATAGACAAAAAAGAGTTGTCAAAGTAAGAGTAATAGTTCCAGATAAGCCAGGGCAACTAAATAAAGTATTAAG
TTATGTGGTTAAGATCCGAGGTAATATAATTGATATAGTTCATGATAGGCATAGTAGCGATGTACTACCGGGATATACTA
AAATATATATAACTTTCGAGCTTCAATCTTCAGAAGCTCTTAGCTTACTTTTGACGAATCTGGCAAATGAAGGTATAGAT
GTTAAAATTGTAGAATAG

Upstream 100 bases:

>100_bases
AGACGCTTGGAGATACGTTTAAAAAATTAAATGCAAAAATTAATGAGATTATGAAGAAGCCCTCGAAATCTGAGTAATTG
ATGAAGGCAGGGTTTTACGG

Downstream 100 bases:

>100_bases
TTTATAAGTCTCTTATGTAGAGATTTTAGGTGGTAGATGCGGATGGAATTTATTATTTAGGTCCAGAGGGAAGTTTTACA
CATGAAGCAGCTACTCTGCT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MNYLEYFDRIRLAKEKIEKYVHTTPIDYSTTFSRITNAKVYLKLENLQKTGSFKVRGAFNKLLSLKEEEKKKGVIAVSAG
NHAQGVAYAASTLNIRSTIVMPETAPASKYLATRSYGADVVLYGKYLHESMKKAEELIQNTGLIFVHPYGDLDVIVGQGT
IGLELYDVEPDYVIIPIGGGGLISGISIALKYRFPNVKIIGVQSSSSPSMKVSKDLGRLVEIEPGYSIADGILVKYPSEL
TFGIINELVDDIVLVDDEEIAEAIVLLLERSKTLAEGAGAAALASLISGKVKVNGIDKKVISLVSGGNIDLSLLSTLTEK
FLYRQKRVVKVRVIVPDKPGQLNKVLSYVVKIRGNIIDIVHDRHSSDVLPGYTKIYITFELQSSEALSLLLTNLANEGID
VKIVE

Sequences:

>Translated_405_residues
MNYLEYFDRIRLAKEKIEKYVHTTPIDYSTTFSRITNAKVYLKLENLQKTGSFKVRGAFNKLLSLKEEEKKKGVIAVSAG
NHAQGVAYAASTLNIRSTIVMPETAPASKYLATRSYGADVVLYGKYLHESMKKAEELIQNTGLIFVHPYGDLDVIVGQGT
IGLELYDVEPDYVIIPIGGGGLISGISIALKYRFPNVKIIGVQSSSSPSMKVSKDLGRLVEIEPGYSIADGILVKYPSEL
TFGIINELVDDIVLVDDEEIAEAIVLLLERSKTLAEGAGAAALASLISGKVKVNGIDKKVISLVSGGNIDLSLLSTLTEK
FLYRQKRVVKVRVIVPDKPGQLNKVLSYVVKIRGNIIDIVHDRHSSDVLPGYTKIYITFELQSSEALSLLLTNLANEGID
VKIVE
>Mature_405_residues
MNYLEYFDRIRLAKEKIEKYVHTTPIDYSTTFSRITNAKVYLKLENLQKTGSFKVRGAFNKLLSLKEEEKKKGVIAVSAG
NHAQGVAYAASTLNIRSTIVMPETAPASKYLATRSYGADVVLYGKYLHESMKKAEELIQNTGLIFVHPYGDLDVIVGQGT
IGLELYDVEPDYVIIPIGGGGLISGISIALKYRFPNVKIIGVQSSSSPSMKVSKDLGRLVEIEPGYSIADGILVKYPSEL
TFGIINELVDDIVLVDDEEIAEAIVLLLERSKTLAEGAGAAALASLISGKVKVNGIDKKVISLVSGGNIDLSLLSTLTEK
FLYRQKRVVKVRVIVPDKPGQLNKVLSYVVKIRGNIIDIVHDRHSSDVLPGYTKIYITFELQSSEALSLLLTNLANEGID
VKIVE

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=320, Percent_Identity=38.75, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=28.9389067524116, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI19923959, Length=307, Percent_Identity=28.6644951140065, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=47.6190476190476, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1790207, Length=329, Percent_Identity=34.3465045592705, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71991565, Length=393, Percent_Identity=37.4045801526718, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17537387, Length=360, Percent_Identity=35, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=29.1139240506329, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=39.413680781759, Blast_Score=192, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6320930, Length=348, Percent_Identity=34.1954022988506, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=276, Percent_Identity=26.4492753623188, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355833, Length=346, Percent_Identity=40.1734104046243, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24645328, Length=266, Percent_Identity=36.8421052631579, Blast_Score=111, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44352; Mature: 44352

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYLEYFDRIRLAKEKIEKYVHTTPIDYSTTFSRITNAKVYLKLENLQKTGSFKVRGAFN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCEEEEHHHH
KLLSLKEEEKKKGVIAVSAGNHAQGVAYAASTLNIRSTIVMPETAPASKYLATRSYGADV
HHHHCCHHHHHCCEEEEECCCCCCCEEEEEEEEEEEEEEEECCCCCCHHHHEECCCCCCE
VLYGKYLHESMKKAEELIQNTGLIFVHPYGDLDVIVGQGTIGLELYDVEPDYVIIPIGGG
EEEHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCEEEEEEEECCCCEEEEEECCC
GLISGISIALKYRFPNVKIIGVQSSSSPSMKVSKDLGRLVEIEPGYSIADGILVKYPSEL
CHHCCEEEEEEEECCCEEEEEEECCCCCCEEEHHCCCCEEEECCCCCCCCCEEEECCCHH
TFGIINELVDDIVLVDDEEIAEAIVLLLERSKTLAEGAGAAALASLISGKVKVNGIDKKV
HHHHHHHHHHHEEEECCHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHCCCEEEECCCHHH
ISLVSGGNIDLSLLSTLTEKFLYRQKRVVKVRVIVPDKPGQLNKVLSYVVKIRGNIIDIV
HHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEE
HDRHSSDVLPGYTKIYITFELQSSEALSLLLTNLANEGIDVKIVE
ECCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MNYLEYFDRIRLAKEKIEKYVHTTPIDYSTTFSRITNAKVYLKLENLQKTGSFKVRGAFN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCEEEEHHHH
KLLSLKEEEKKKGVIAVSAGNHAQGVAYAASTLNIRSTIVMPETAPASKYLATRSYGADV
HHHHCCHHHHHCCEEEEECCCCCCCEEEEEEEEEEEEEEEECCCCCCHHHHEECCCCCCE
VLYGKYLHESMKKAEELIQNTGLIFVHPYGDLDVIVGQGTIGLELYDVEPDYVIIPIGGG
EEEHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCEEEEEEEECCCCEEEEEECCC
GLISGISIALKYRFPNVKIIGVQSSSSPSMKVSKDLGRLVEIEPGYSIADGILVKYPSEL
CHHCCEEEEEEEECCCEEEEEEECCCCCCEEEHHCCCCEEEECCCCCCCCCEEEECCCHH
TFGIINELVDDIVLVDDEEIAEAIVLLLERSKTLAEGAGAAALASLISGKVKVNGIDKKV
HHHHHHHHHHHEEEECCHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHCCCEEEECCCHHH
ISLVSGGNIDLSLLSTLTEKFLYRQKRVVKVRVIVPDKPGQLNKVLSYVVKIRGNIIDIV
HHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEE
HDRHSSDVLPGYTKIYITFELQSSEALSLLLTNLANEGIDVKIVE
ECCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA