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The map label for this gene is atpI [H]

Identifier: 227827836

GI number: 227827836

Start: 1457563

End: 1459668

Strand: Direct

Name: atpI [H]

Synonym: M1425_1569

Alternate gene names: 227827836

Gene position: 1457563-1459668 (Clockwise)

Preceding gene: 227827823

Following gene: 227827838

Centisome position: 55.87

GC content: 35.33

Gene sequence:

>2106_bases
GTGCTATTACCAGAGAATATGGTCAGATTACAAATAATTTCTGATAAGTCCGCTGTAGACCCTATTGTAACTAAACTTCT
AAAGCTTGGTATGTTTCAACCAGAGGATCCCCTTTATCCATTAAGTAATGAGAGAATAGAAGATGCTAGAAGACTAATTA
CTGCAGTCCAAGATCACGTAAGCAAATTAAAAATAATCATGGAGTTAGGAGGATTAGTAATAGAGCCATTAGGAAGCATA
AAAGTAGTTAACTGGATTAAGGCTGCACAAGATGTCAGTGAAGAAGCGTCGAAATTAGAAGAAAGATACAAGGAACTATT
GGAGGAAATAGGTAGGCTAAGGGCAGAAAAGGATCTGTATCAGCAACAGTTAAAAGAGCTGGAACCGATTAAGTCAATAA
CAGTAGAGTTATCCAAATTATACTCCTTAGAGTTATTTGACGTAATATTAGCTCAAGTTAGCGAGGATAAGTTAAGGCTT
ATCAGTCAAATAATAGGTGATTCCGGTTTCGCATATTACACGAGATTCGAAGAAGGAAAATATACTGTGCTGATTATTAC
TGAGAAGAATGCAGATATAGAAAAGAAATTAAAAGAGACTGGAGTCAGAAGATATGAGCTGCAAGAAGGAAAGTCTCCCT
TTCAGCTCTATAATGAGATTTCAGAGAGAATAAACCAGATAAATACTATTTTGGAAAGAACAAGAGAAGAATTGGCAAAG
AAAGTAAAGACTGAGGAGAATTATATTAAAAATGTATACGGTAAATTGCTTACAGTTCGAGACGCGTTAAATATCATGAA
TAAAGCTAGAATCTCTGAGTATTATTTACAAATAGAAGGTTATCTTCCTGAAAAATATGTTAAAAGAGTACAAAATGAAA
TGAAGGATCTTGCACATGTGGATTATATAAGACCTAGGAGATATGGTGAAAAGGAGGAACCACCAACACTAGTCGAATTA
CCAAAGTCAATAAAGGTTTTAGAATCCTTAGTAGAAATATATGGTTCACCGTCCTATTGGGAAATCTCGCCAATAGTCTT
TCTTGTTTTCACTTTCCCGATATTATTTGGACTAATGTTCCCTGATTTTGGAAACGCTTTAGTTCTATTGTTATTCTCAA
TATGGTTCTATAGATATGGAAAGAAAAGAGGTAGTGAGAATATTCCTAAATTATCTATTATTCTAATATACTCGAGTATA
GTTGCAATGATAACGGGTCTGTTAGCAAGAGATTTCTTTGGTCCATTGCCAGTAGGTGGATTAAGGGAGATATTAAATAA
TGGGAACTATAGTGCTGGGCCTCTTTACAACTTATGGCCAATTCCAGCAAGCGTATCTGAAGCGATAAAGTTCCTCTTAC
CCTTTGGTGAGTATAGCACTAGTGTTAGTATAGAAAATACCATGATATTCTCAGTATTACTGGGTGCTATCGCGCTATTT
GTAAGTTCCTTACTAGGTATTATAGATGCTATCAGAAAGAAGGATTCGGAATTCTTATTTTTAGAAAAACTTCCACTATT
CTTACTATACGTTGTTCCAATATTCATCTTCATGTACGGTATAACAGATCCAGCCAATTTCTTTATAGTTGATCAAAGGA
TACTGGGCCAAATACTTAACGCTGTTCTTATGAAATCCCTTAGCGAAAATATAATAGGTTATGGAATAGTTTGGTGGACG
TCATTTGCACTATTATATAACTGGGTTGCTCATGCAATTTTAGTTAAAAGGCATGATAATGCGACATGGGGTTCTGCGAT
TGCCATGGGTTTCATAGAAGGTGGATTTGAAGGAGCATTACTATTACTGTCCAATACCATTTCATTTATAAGAGTGTTAG
TTTTCGCTTTATCGCACTATTATATACTGTACGCATTCTCCTATATGGCCTATCTAGTTGCACCATCCACAACTACCATA
GGAGTCCTACTAAATCCCATAGCAATAGTTATACTGATTATAGGAAACTTGTTAGCAATAGGTTTAGAAGGGTTGGTAGT
ATTCATACAAGATTTAAGGCTTCATTTCTACGAGATGTTCAGTAAGTTCTATGAAGGTAGAGGAAGAAAATTCGAGCCAG
TTATGGCTTATGTCTCACTTGAGTAA

Upstream 100 bases:

>100_bases
TCTCCCACAACAAACACTTTACCCATTGCGAATTAATTCTAAATAACAGAGATTAAATACTTATAAGTGACCTACTAATA
CATATCCCGAGGTAATTAAA

Downstream 100 bases:

>100_bases
GGTAGGTCTCATTTTTTCTATATCCTTTCTTATTTTTTCTAGCTTGTCTTTAATCTTAGACTCAAATTCTGGTTCAAGTT
TCTTGAAAAGTACTTTAACT

Product: V-type ATP synthase subunit I

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit I [H]

Number of amino acids: Translated: 701; Mature: 701

Protein sequence:

>701_residues
MLLPENMVRLQIISDKSAVDPIVTKLLKLGMFQPEDPLYPLSNERIEDARRLITAVQDHVSKLKIIMELGGLVIEPLGSI
KVVNWIKAAQDVSEEASKLEERYKELLEEIGRLRAEKDLYQQQLKELEPIKSITVELSKLYSLELFDVILAQVSEDKLRL
ISQIIGDSGFAYYTRFEEGKYTVLIITEKNADIEKKLKETGVRRYELQEGKSPFQLYNEISERINQINTILERTREELAK
KVKTEENYIKNVYGKLLTVRDALNIMNKARISEYYLQIEGYLPEKYVKRVQNEMKDLAHVDYIRPRRYGEKEEPPTLVEL
PKSIKVLESLVEIYGSPSYWEISPIVFLVFTFPILFGLMFPDFGNALVLLLFSIWFYRYGKKRGSENIPKLSIILIYSSI
VAMITGLLARDFFGPLPVGGLREILNNGNYSAGPLYNLWPIPASVSEAIKFLLPFGEYSTSVSIENTMIFSVLLGAIALF
VSSLLGIIDAIRKKDSEFLFLEKLPLFLLYVVPIFIFMYGITDPANFFIVDQRILGQILNAVLMKSLSENIIGYGIVWWT
SFALLYNWVAHAILVKRHDNATWGSAIAMGFIEGGFEGALLLLSNTISFIRVLVFALSHYYILYAFSYMAYLVAPSTTTI
GVLLNPIAIVILIIGNLLAIGLEGLVVFIQDLRLHFYEMFSKFYEGRGRKFEPVMAYVSLE

Sequences:

>Translated_701_residues
MLLPENMVRLQIISDKSAVDPIVTKLLKLGMFQPEDPLYPLSNERIEDARRLITAVQDHVSKLKIIMELGGLVIEPLGSI
KVVNWIKAAQDVSEEASKLEERYKELLEEIGRLRAEKDLYQQQLKELEPIKSITVELSKLYSLELFDVILAQVSEDKLRL
ISQIIGDSGFAYYTRFEEGKYTVLIITEKNADIEKKLKETGVRRYELQEGKSPFQLYNEISERINQINTILERTREELAK
KVKTEENYIKNVYGKLLTVRDALNIMNKARISEYYLQIEGYLPEKYVKRVQNEMKDLAHVDYIRPRRYGEKEEPPTLVEL
PKSIKVLESLVEIYGSPSYWEISPIVFLVFTFPILFGLMFPDFGNALVLLLFSIWFYRYGKKRGSENIPKLSIILIYSSI
VAMITGLLARDFFGPLPVGGLREILNNGNYSAGPLYNLWPIPASVSEAIKFLLPFGEYSTSVSIENTMIFSVLLGAIALF
VSSLLGIIDAIRKKDSEFLFLEKLPLFLLYVVPIFIFMYGITDPANFFIVDQRILGQILNAVLMKSLSENIIGYGIVWWT
SFALLYNWVAHAILVKRHDNATWGSAIAMGFIEGGFEGALLLLSNTISFIRVLVFALSHYYILYAFSYMAYLVAPSTTTI
GVLLNPIAIVILIIGNLLAIGLEGLVVFIQDLRLHFYEMFSKFYEGRGRKFEPVMAYVSLE
>Mature_701_residues
MLLPENMVRLQIISDKSAVDPIVTKLLKLGMFQPEDPLYPLSNERIEDARRLITAVQDHVSKLKIIMELGGLVIEPLGSI
KVVNWIKAAQDVSEEASKLEERYKELLEEIGRLRAEKDLYQQQLKELEPIKSITVELSKLYSLELFDVILAQVSEDKLRL
ISQIIGDSGFAYYTRFEEGKYTVLIITEKNADIEKKLKETGVRRYELQEGKSPFQLYNEISERINQINTILERTREELAK
KVKTEENYIKNVYGKLLTVRDALNIMNKARISEYYLQIEGYLPEKYVKRVQNEMKDLAHVDYIRPRRYGEKEEPPTLVEL
PKSIKVLESLVEIYGSPSYWEISPIVFLVFTFPILFGLMFPDFGNALVLLLFSIWFYRYGKKRGSENIPKLSIILIYSSI
VAMITGLLARDFFGPLPVGGLREILNNGNYSAGPLYNLWPIPASVSEAIKFLLPFGEYSTSVSIENTMIFSVLLGAIALF
VSSLLGIIDAIRKKDSEFLFLEKLPLFLLYVVPIFIFMYGITDPANFFIVDQRILGQILNAVLMKSLSENIIGYGIVWWT
SFALLYNWVAHAILVKRHDNATWGSAIAMGFIEGGFEGALLLLSNTISFIRVLVFALSHYYILYAFSYMAYLVAPSTTTI
GVLLNPIAIVILIIGNLLAIGLEGLVVFIQDLRLHFYEMFSKFYEGRGRKFEPVMAYVSLE

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane [H]

COG id: COG1269

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase 116 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI42741679, Length=388, Percent_Identity=23.1958762886598, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI19913418, Length=229, Percent_Identity=23.1441048034935, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI194097403, Length=229, Percent_Identity=23.1441048034935, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI194097401, Length=229, Percent_Identity=23.1441048034935, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17542706, Length=186, Percent_Identity=26.8817204301075, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17536635, Length=316, Percent_Identity=21.8354430379747, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24647955, Length=333, Percent_Identity=24.6246246246246, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357019, Length=333, Percent_Identity=24.6246246246246, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357061, Length=335, Percent_Identity=24.7761194029851, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650967, Length=209, Percent_Identity=24.8803827751196, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650965, Length=209, Percent_Identity=24.8803827751196, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650959, Length=206, Percent_Identity=25.2427184466019, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650961, Length=206, Percent_Identity=25.2427184466019, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551995, Length=209, Percent_Identity=24.8803827751196, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650963, Length=206, Percent_Identity=25.2427184466019, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281362794, Length=206, Percent_Identity=25.2427184466019, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281362792, Length=206, Percent_Identity=25.2427184466019, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358171, Length=206, Percent_Identity=25.2427184466019, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650956, Length=206, Percent_Identity=25.2427184466019, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583722, Length=315, Percent_Identity=22.2222222222222, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002490 [H]

Pfam domain/function: PF01496 V_ATPase_I [H]

EC number: 3.6.3.14

Molecular weight: Translated: 80040; Mature: 80040

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPENMVRLQIISDKSAVDPIVTKLLKLGMFQPEDPLYPLSNERIEDARRLITAVQDHV
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SKLKIIMELGGLVIEPLGSIKVVNWIKAAQDVSEEASKLEERYKELLEEIGRLRAEKDLY
HHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQQLKELEPIKSITVELSKLYSLELFDVILAQVSEDKLRLISQIIGDSGFAYYTRFEEGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCC
YTVLIITEKNADIEKKLKETGVRRYELQEGKSPFQLYNEISERINQINTILERTREELAK
EEEEEEECCCCCHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVKTEENYIKNVYGKLLTVRDALNIMNKARISEYYLQIEGYLPEKYVKRVQNEMKDLAHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHH
DYIRPRRYGEKEEPPTLVELPKSIKVLESLVEIYGSPSYWEISPIVFLVFTFPILFGLMF
HHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHC
PDFGNALVLLLFSIWFYRYGKKRGSENIPKLSIILIYSSIVAMITGLLARDFFGPLPVGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LREILNNGNYSAGPLYNLWPIPASVSEAIKFLLPFGEYSTSVSIENTMIFSVLLGAIALF
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHH
VSSLLGIIDAIRKKDSEFLFLEKLPLFLLYVVPIFIFMYGITDPANFFIVDQRILGQILN
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHH
AVLMKSLSENIIGYGIVWWTSFALLYNWVAHAILVKRHDNATWGSAIAMGFIEGGFEGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCHHH
LLLSNTISFIRVLVFALSHYYILYAFSYMAYLVAPSTTTIGVLLNPIAIVILIIGNLLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLEGLVVFIQDLRLHFYEMFSKFYEGRGRKFEPVMAYVSLE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
>Mature Secondary Structure
MLLPENMVRLQIISDKSAVDPIVTKLLKLGMFQPEDPLYPLSNERIEDARRLITAVQDHV
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SKLKIIMELGGLVIEPLGSIKVVNWIKAAQDVSEEASKLEERYKELLEEIGRLRAEKDLY
HHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQQLKELEPIKSITVELSKLYSLELFDVILAQVSEDKLRLISQIIGDSGFAYYTRFEEGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCC
YTVLIITEKNADIEKKLKETGVRRYELQEGKSPFQLYNEISERINQINTILERTREELAK
EEEEEEECCCCCHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVKTEENYIKNVYGKLLTVRDALNIMNKARISEYYLQIEGYLPEKYVKRVQNEMKDLAHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHH
DYIRPRRYGEKEEPPTLVELPKSIKVLESLVEIYGSPSYWEISPIVFLVFTFPILFGLMF
HHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHC
PDFGNALVLLLFSIWFYRYGKKRGSENIPKLSIILIYSSIVAMITGLLARDFFGPLPVGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LREILNNGNYSAGPLYNLWPIPASVSEAIKFLLPFGEYSTSVSIENTMIFSVLLGAIALF
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHH
VSSLLGIIDAIRKKDSEFLFLEKLPLFLLYVVPIFIFMYGITDPANFFIVDQRILGQILN
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHH
AVLMKSLSENIIGYGIVWWTSFALLYNWVAHAILVKRHDNATWGSAIAMGFIEGGFEGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCHHH
LLLSNTISFIRVLVFALSHYYILYAFSYMAYLVAPSTTTIGVLLNPIAIVILIIGNLLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLEGLVVFIQDLRLHFYEMFSKFYEGRGRKFEPVMAYVSLE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]