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The map label for this gene is hom [H]

Identifier: 227827748

GI number: 227827748

Start: 1383885

End: 1384829

Strand: Direct

Name: hom [H]

Synonym: M1425_1479

Alternate gene names: 227827748

Gene position: 1383885-1384829 (Clockwise)

Preceding gene: 227827747

Following gene: 227827749

Centisome position: 53.05

GC content: 35.24

Gene sequence:

>945_bases
ATGAAGTTACTTTTAATCGGATATGGAAATGTTGGAAAGGCATTTAGAAGACTGCTACATGAAAAGAGAGATAGTTATCC
AATATTGCAAAATGTTGAGATAGCAGGGATGCTAACTAGGCAGGGATTAATGGTTGGGGATAAGGAGAATTTCTCTCCAG
ATAAGCAAATAACTGTATTAGAAGCAATTGATTTCATAAACCCAGATGTTATTGTTGATATGTCTGCACCTAATTATAAA
GATGGTGAGCCGTCCGTTAGCGCTTACATAAAGGCATTGTCAAGAAAAATTCACGTGATAACAGTAAATAAAGCACCATT
AGCACTAAAGTTTAGGGAAATATTTGAAGTTGCTGAGAGAACTGGTGCTAAAATTGGATTCCAAGGAACTGTGATGAGTG
GTACTCCTTCCATAAATCTCTTTAGGATTCAACCAGTAGCTGAGGTCTCTAGGATTAGGGGTATCCTTAATGGTACCACA
AACTATATTTTGAGTAGGATTTATGAAGGGTTAAGTTTTAATGAAGCCTTGAAAGAGGCTAAAGAAAAAGGTTATGCAGA
GGAAGACCCAACTTTAGATCTTAATGGGTTTGATGCTGCAGCTAAACTGACAATTTTATCAAATTTTATTATGAACAGAA
GCATAAGACTAGGTGACTTCAAGTTCAAGGGAATAACTGAGATTAGTAATGAAGAGATTAGAAGAGCTAAAAGTGAAGGT
AAGAAAATAAAATTAATAGCCTATGCGGATAACTATATAATACAAGTATCTCCTCAAATTATAGGTCCACAAGATCCATT
ATATTATATAGACGGAGTTGAAAATGCTCTAGAAATTCAAAATGAAATACAGAGGATAATTATTAGAGGTCCAGGGGCAG
GTCCAACAAATGCTGCATATGGTGCTCTTACAGATTTGGTGTTATTATTGGAAGGATGTTTATGA

Upstream 100 bases:

>100_bases
ATATCGATGAAAATCTAGTCAAATATGCAGTAGATCGCGTAGCAGATTTATTAGAAAAGATATGTAAAGGAAAGAGAGAG
TATGATACTGTGGTGATTAA

Downstream 100 bases:

>100_bases
CAATTTTTTTATTCTTATAATACAATTGTAACTTGATGAGTTTACAGCAGAAAATAAAGGCTTATTTAAAGTTGGGTAAA
CTTGGGGTAGTAAGCTTACT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKLLLIGYGNVGKAFRRLLHEKRDSYPILQNVEIAGMLTRQGLMVGDKENFSPDKQITVLEAIDFINPDVIVDMSAPNYK
DGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAERTGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTT
NYILSRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSIRLGDFKFKGITEISNEEIRRAKSEG
KKIKLIAYADNYIIQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPTNAAYGALTDLVLLLEGCL

Sequences:

>Translated_314_residues
MKLLLIGYGNVGKAFRRLLHEKRDSYPILQNVEIAGMLTRQGLMVGDKENFSPDKQITVLEAIDFINPDVIVDMSAPNYK
DGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAERTGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTT
NYILSRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSIRLGDFKFKGITEISNEEIRRAKSEG
KKIKLIAYADNYIIQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPTNAAYGALTDLVLLLEGCL
>Mature_314_residues
MKLLLIGYGNVGKAFRRLLHEKRDSYPILQNVEIAGMLTRQGLMVGDKENFSPDKQITVLEAIDFINPDVIVDMSAPNYK
DGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAERTGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTT
NYILSRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSIRLGDFKFKGITEISNEEIRRAKSEG
KKIKLIAYADNYIIQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPTNAAYGALTDLVLLLEGCL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=317, Percent_Identity=27.1293375394322, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790376, Length=331, Percent_Identity=25.3776435045317, Blast_Score=78, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322599, Length=148, Percent_Identity=32.4324324324324, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 34781; Mature: 34781

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLLIGYGNVGKAFRRLLHEKRDSYPILQNVEIAGMLTRQGLMVGDKENFSPDKQITVL
CEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHCCEEECCCCCCCCCCCEEHH
EAIDFINPDVIVDMSAPNYKDGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAER
HHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHH
TGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTTNYILSRIYEGLSFNEALKEA
CCCEECCCEEEECCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
KEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSIRLGDFKFKGITEISNEEIRRAKSEG
HHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEECCEEECCCCCCCHHHHHHHHHCC
KKIKLIAYADNYIIQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPTNAAY
CEEEEEEEECCEEEEECCCEECCCCCEEEECCCHHHHHHHHHHHEEEEECCCCCCCCHHH
GALTDLVLLLEGCL
HHHHHHHHHHHCCC
>Mature Secondary Structure
MKLLLIGYGNVGKAFRRLLHEKRDSYPILQNVEIAGMLTRQGLMVGDKENFSPDKQITVL
CEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHCCEEECCCCCCCCCCCEEHH
EAIDFINPDVIVDMSAPNYKDGEPSVSAYIKALSRKIHVITVNKAPLALKFREIFEVAER
HHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHH
TGAKIGFQGTVMSGTPSINLFRIQPVAEVSRIRGILNGTTNYILSRIYEGLSFNEALKEA
CCCEECCCEEEECCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
KEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSIRLGDFKFKGITEISNEEIRRAKSEG
HHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEECCEEECCCCCCCHHHHHHHHHCC
KKIKLIAYADNYIIQVSPQIIGPQDPLYYIDGVENALEIQNEIQRIIIRGPGAGPTNAAY
CEEEEEEEECCEEEEECCCEECCCCCEEEECCCHHHHHHHHHHHEEEEECCCCCCCCHHH
GALTDLVLLLEGCL
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]