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The map label for this gene is ubiA

Identifier: 227827749

GI number: 227827749

Start: 1384865

End: 1385722

Strand: Direct

Name: ubiA

Synonym: M1425_1480

Alternate gene names: 227827749

Gene position: 1384865-1385722 (Clockwise)

Preceding gene: 227827748

Following gene: 227827751

Centisome position: 53.08

GC content: 33.68

Gene sequence:

>858_bases
ATGAGTTTACAGCAGAAAATAAAGGCTTATTTAAAGTTGGGTAAACTTGGGGTAGTAAGCTTACTTGATTTAGCAGCAGT
TGCTGGGGCTTTTTTAGCTTACAAACATGGCATTTCACTTTTACCAATAATTCCTATGTTCATTGGAGGTACTTTAGCGT
CGATGGGAGCTATGATAATTAATAGTGGGATTGAAATAGATAGAGATAAAGTAATGTCTAGAACGTCAAAGAGACCTACA
GTAGTTGGCTATGTCAATAGGAAGGAAGCTATAATAGTTGGTTCACTTCTAGCAATTTTAGGTACGGCATTAGGTTTTAT
AGACAATATTTTGACTGCTTTCTTTATAGCATTAGGTGTAGTAATATATATATTCGTATATACAATCTTATTGAAACCTA
GGACTTGGCTAAATATAGTGATAGGTGGATTTGCTGGCAGCGCTGCAGCTTGGGCTGGTTACACGTCCTTAACAAATTCT
TTAACTTTAGAAGGATTTCTTTTAGGTTTTCTAATATTTATGTGGACTCCTGGCCATTTCTGGTCGTTGGCATTGAAGTA
TAGAGAAGATTATGTTAACGCGCATTATCCCATGCTGCCTGCTGTGGTTGGAATAACAACTTCTGCAAGGGCAATAGCAA
TTTCTAATGCCTTAATGATTCCCATTGTACTTTTGCTAGGATACTATATTAATCTAATAGCGCTTATAGCATTTTCCATT
TTAAGTTTATTTCTAATGTTTCTTTCTTATAGGTTAATACTTAATCCAACTAAAGAAGAAGCAATTAAATCGTTTATATT
TTCAAACATTTACCTAATGCTAATACTTTTAATTATGATAATAGTCAAACTAATATGA

Upstream 100 bases:

>100_bases
GTCCAACAAATGCTGCATATGGTGCTCTTACAGATTTGGTGTTATTATTGGAAGGATGTTTATGACAATTTTTTTATTCT
TATAATACAATTGTAACTTG

Downstream 100 bases:

>100_bases
AATATCTATTACCATGTCAGCTATTTTCTTAGACGAGATTACAATTCTAATATCAATATCCCCACATTTTCTCCTTATTA
CTAACTTGTCCTCATTTTGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSLQQKIKAYLKLGKLGVVSLLDLAAVAGAFLAYKHGISLLPIIPMFIGGTLASMGAMIINSGIEIDRDKVMSRTSKRPT
VVGYVNRKEAIIVGSLLAILGTALGFIDNILTAFFIALGVVIYIFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNS
LTLEGFLLGFLIFMWTPGHFWSLALKYREDYVNAHYPMLPAVVGITTSARAIAISNALMIPIVLLLGYYINLIALIAFSI
LSLFLMFLSYRLILNPTKEEAIKSFIFSNIYLMLILLIMIIVKLI

Sequences:

>Translated_285_residues
MSLQQKIKAYLKLGKLGVVSLLDLAAVAGAFLAYKHGISLLPIIPMFIGGTLASMGAMIINSGIEIDRDKVMSRTSKRPT
VVGYVNRKEAIIVGSLLAILGTALGFIDNILTAFFIALGVVIYIFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNS
LTLEGFLLGFLIFMWTPGHFWSLALKYREDYVNAHYPMLPAVVGITTSARAIAISNALMIPIVLLLGYYINLIALIAFSI
LSLFLMFLSYRLILNPTKEEAIKSFIFSNIYLMLILLIMIIVKLI
>Mature_284_residues
SLQQKIKAYLKLGKLGVVSLLDLAAVAGAFLAYKHGISLLPIIPMFIGGTLASMGAMIINSGIEIDRDKVMSRTSKRPTV
VGYVNRKEAIIVGSLLAILGTALGFIDNILTAFFIALGVVIYIFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNSL
TLEGFLLGFLIFMWTPGHFWSLALKYREDYVNAHYPMLPAVVGITTSARAIAISNALMIPIVLLLGYYINLIALIAFSIL
SLFLMFLSYRLILNPTKEEAIKSFIFSNIYLMLILLIMIIVKLI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=283, Percent_Identity=25.7950530035336, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786631, Length=208, Percent_Identity=27.8846153846154, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=258, Percent_Identity=28.2945736434109, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921064, Length=294, Percent_Identity=25.8503401360544, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_SULIA (C3N652)

Other databases:

- EMBL:   CP001401
- RefSeq:   YP_002843522.1
- GeneID:   7814529
- GenomeReviews:   CP001401_GR
- KEGG:   sim:M1627_1595
- OMA:   MALTEEW
- ProtClustDB:   PRK12869
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 31250; Mature: 31119

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ca5ca58)-; HASH(0x1d8fa6c4)-; HASH(0x1daecf78)-; HASH(0x1d9abb3c)-; HASH(0x1d785a78)-; HASH(0x1d0731dc)-; HASH(0x1d106054)-; HASH(0x1d75b948)-; HASH(0x1d748fac)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQQKIKAYLKLGKLGVVSLLDLAAVAGAFLAYKHGISLLPIIPMFIGGTLASMGAMII
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NSGIEIDRDKVMSRTSKRPTVVGYVNRKEAIIVGSLLAILGTALGFIDNILTAFFIALGV
HCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIYIFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNSLTLEGFLLGFLIFMWTPGHF
HHHHHHHHHHHCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
WSLALKYREDYVNAHYPMLPAVVGITTSARAIAISNALMIPIVLLLGYYINLIALIAFSI
HHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLFLMFLSYRLILNPTKEEAIKSFIFSNIYLMLILLIMIIVKLI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure 
SLQQKIKAYLKLGKLGVVSLLDLAAVAGAFLAYKHGISLLPIIPMFIGGTLASMGAMII
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NSGIEIDRDKVMSRTSKRPTVVGYVNRKEAIIVGSLLAILGTALGFIDNILTAFFIALGV
HCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIYIFVYTILLKPRTWLNIVIGGFAGSAAAWAGYTSLTNSLTLEGFLLGFLIFMWTPGHF
HHHHHHHHHHHCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
WSLALKYREDYVNAHYPMLPAVVGITTSARAIAISNALMIPIVLLLGYYINLIALIAFSI
HHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLFLMFLSYRLILNPTKEEAIKSFIFSNIYLMLILLIMIIVKLI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA