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The map label for this gene is secY [H]

Identifier: 227827714

GI number: 227827714

Start: 1351516

End: 1352925

Strand: Direct

Name: secY [H]

Synonym: M1425_1443

Alternate gene names: 227827714

Gene position: 1351516-1352925 (Clockwise)

Preceding gene: 227827713

Following gene: 227827715

Centisome position: 51.81

GC content: 35.46

Gene sequence:

>1410_bases
ATGTCATTCATCGATTCACTCGCCACTCTTGGGCAATACTTGCCAGCGGTTACTAAACCTAAAGAGAAACCTTCGCTAGG
TCAAAAGTTAATTTGGTCCTTAGTAGCAGTGATAATTTATCTGATAATGGCTTCAACTCCTTTGTACGGTATAACTTCAG
CTTCTTTTTTTAAGAACCTTATTTTAGAACAGATTATTTTTGCTTCTACTACAGGGACATTAGCGCAATTAGGAATAGGT
CCTATAATAACTGCAGGTTTAATTATGCAAATATTAGCCGGATCTAAGTTAATAGGAATTGATCTAAATGACGCTGATGA
TAGGGTTAGATTTACGGAAGCACAAAAGGGATTAGCGTTTATCTTCATTCTAGTGGAGTCAGCTTTATTTGGTTATGTAT
TAGCTAGAACTTCAACAACCATAAATGCGTCAATATTATTTACTGCAGGAATAGTAATAGCTCAGCTTATTGTAGCCACA
TATTTGATCTTACTGTTAGACGAGCTAATACAGAAAGGTTGGGGCTTAGGATCTGGAGTTAGTCTGTTTATACTAGCTGG
AGTTATGAAGATAATGTTTTGGGACATGTTTGGAATTGCAAGCGTTAGTTCCCAGAATTTACCGATAGGTTTCTTCCCTG
CATTATTTACGGCATTTGCATCGCATAGTGATATTCTCAATTTAATAGTTAATACGTCAACTAAAAATCTCTTTCAGCCA
GATTTAGTTGGTTTGATAACCACTATAGTATTGATTATCATAACAATTTATCTAACTACGATGACCATAGAAATACCGGT
AACTTCCCAAAAGTTAAGAGGTATAAGGAGAACAATTCCGTTAAACTTTCTATATGTTAGCAGTATACCAGTAATATTTG
TTGCAGTACTAGGTTCTGATATCCAGTTATTTGCATCATTAGCTTCCTATGTTTCGCCCTCAGCTTCAAATATACTAAAT
ACTATTAGTGGAGTATTCTTTTTCCCTCCTCCAAATTCAGCGATACCTCATAGTGTATATGCTATAGTTTTAGATCCATT
AGGGGCACTTGAATATGCTGTAGTTTTCATAGTTCTTAGTATTTTGTTTGGTATATTATGGGTTGACGTAGCTGGTTTAG
ACCCCGCTACTCAAGCACAACAGTTAATTGAAGCTGGTATTGAAATACCTGGTGTTCGAAGTAATCCAAAGATTATAGAG
GGGATATTAGCTAGGTATATATATCCATTGGCATTCTTCAGTTCTATCATCGTAGGTTTAATTGCAGTATTTGCTACACT
CCTAGGTGCATACGGTACTGGTATAGGGATACTATTAGCTGTAACAATAGCAATACAATACTATAGCTTATTAGCTTATG
AAAGATCTTTAGAAATGTACCCATTACTAAAGAGGTTGATAGGTGAATAG

Upstream 100 bases:

>100_bases
ATAAAAGTAGGTAAGGCTACCGATAGAGCGATACAGAAAGTGAAGCAGATAGGAGGAGAAGTAATATTAAGCCCAACTGA
GTAATTTTTTTGAGTAAATT

Downstream 100 bases:

>100_bases
GTATGAAAATAGGTATTGTAACAGGTATACCCGGTGTAGGTAAGACAACTGTCCTTTCTTTTGCAGATAAAATTCTAACT
GAAAAGGGTATACCACACAA

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSFIDSLATLGQYLPAVTKPKEKPSLGQKLIWSLVAVIIYLIMASTPLYGITSASFFKNLILEQIIFASTTGTLAQLGIG
PIITAGLIMQILAGSKLIGIDLNDADDRVRFTEAQKGLAFIFILVESALFGYVLARTSTTINASILFTAGIVIAQLIVAT
YLILLLDELIQKGWGLGSGVSLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTAFASHSDILNLIVNTSTKNLFQP
DLVGLITTIVLIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSDIQLFASLASYVSPSASNILN
TISGVFFFPPPNSAIPHSVYAIVLDPLGALEYAVVFIVLSILFGILWVDVAGLDPATQAQQLIEAGIEIPGVRSNPKIIE
GILARYIYPLAFFSSIIVGLIAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE

Sequences:

>Translated_469_residues
MSFIDSLATLGQYLPAVTKPKEKPSLGQKLIWSLVAVIIYLIMASTPLYGITSASFFKNLILEQIIFASTTGTLAQLGIG
PIITAGLIMQILAGSKLIGIDLNDADDRVRFTEAQKGLAFIFILVESALFGYVLARTSTTINASILFTAGIVIAQLIVAT
YLILLLDELIQKGWGLGSGVSLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTAFASHSDILNLIVNTSTKNLFQP
DLVGLITTIVLIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSDIQLFASLASYVSPSASNILN
TISGVFFFPPPNSAIPHSVYAIVLDPLGALEYAVVFIVLSILFGILWVDVAGLDPATQAQQLIEAGIEIPGVRSNPKIIE
GILARYIYPLAFFSSIIVGLIAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE
>Mature_468_residues
SFIDSLATLGQYLPAVTKPKEKPSLGQKLIWSLVAVIIYLIMASTPLYGITSASFFKNLILEQIIFASTTGTLAQLGIGP
IITAGLIMQILAGSKLIGIDLNDADDRVRFTEAQKGLAFIFILVESALFGYVLARTSTTINASILFTAGIVIAQLIVATY
LILLLDELIQKGWGLGSGVSLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTAFASHSDILNLIVNTSTKNLFQPD
LVGLITTIVLIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSDIQLFASLASYVSPSASNILNT
ISGVFFFPPPNSAIPHSVYAIVLDPLGALEYAVVFIVLSILFGILWVDVAGLDPATQAQQLIEAGIEIPGVRSNPKIIEG
ILARYIYPLAFFSSIIVGLIAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI7019415, Length=481, Percent_Identity=32.016632016632, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI14589847, Length=484, Percent_Identity=30.7851239669421, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI217330618, Length=484, Percent_Identity=29.9586776859504, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI217330616, Length=428, Percent_Identity=28.9719626168224, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17543770, Length=480, Percent_Identity=31.4583333333333, Blast_Score=208, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6323411, Length=473, Percent_Identity=30.6553911205074, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319760, Length=452, Percent_Identity=25.8849557522124, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19920826, Length=484, Percent_Identity=31.8181818181818, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 50559; Mature: 50428

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00755 SECY_1 ; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIDSLATLGQYLPAVTKPKEKPSLGQKLIWSLVAVIIYLIMASTPLYGITSASFFKNL
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILEQIIFASTTGTLAQLGIGPIITAGLIMQILAGSKLIGIDLNDADDRVRFTEAQKGLAF
HHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCHHH
IFILVESALFGYVLARTSTTINASILFTAGIVIAQLIVATYLILLLDELIQKGWGLGSGV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
SLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTAFASHSDILNLIVNTSTKNLFQP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCH
DLVGLITTIVLIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSD
HHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCH
IQLFASLASYVSPSASNILNTISGVFFFPPPNSAIPHSVYAIVLDPLGALEYAVVFIVLS
HHHHHHHHHHHCCCHHHHHHHHCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
ILFGILWVDVAGLDPATQAQQLIEAGIEIPGVRSNPKIIEGILARYIYPLAFFSSIIVGL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
SFIDSLATLGQYLPAVTKPKEKPSLGQKLIWSLVAVIIYLIMASTPLYGITSASFFKNL
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILEQIIFASTTGTLAQLGIGPIITAGLIMQILAGSKLIGIDLNDADDRVRFTEAQKGLAF
HHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCHHH
IFILVESALFGYVLARTSTTINASILFTAGIVIAQLIVATYLILLLDELIQKGWGLGSGV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
SLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTAFASHSDILNLIVNTSTKNLFQP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCH
DLVGLITTIVLIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSD
HHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCH
IQLFASLASYVSPSASNILNTISGVFFFPPPNSAIPHSVYAIVLDPLGALEYAVVFIVLS
HHHHHHHHHHHCCCHHHHHHHHCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
ILFGILWVDVAGLDPATQAQQLIEAGIEIPGVRSNPKIIEGILARYIYPLAFFSSIIVGL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]