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The map label for this gene is moaC [H]

Identifier: 227827644

GI number: 227827644

Start: 1298043

End: 1298492

Strand: Direct

Name: moaC [H]

Synonym: M1425_1372

Alternate gene names: 227827644

Gene position: 1298043-1298492 (Clockwise)

Preceding gene: 227827643

Following gene: 227827650

Centisome position: 49.76

GC content: 32.89

Gene sequence:

>450_bases
ATGAGTTCCGAAGCTAAAATGGTAGATATATCTCCAAAGGAAACTATATTAAGAGTAGCAGAAGCTGAGGGATTCATTAA
ACTAAAAAACGATACTATAAGGAGAATTATGGAAAATGAAGTAGAGAAGGGGAACGTGATTGCTGTTGCAAAAACCGCAG
GGATAATGGCTGCAAAGAAAACGTCTGAGCTTTTACCTCTATGCCATTTAATACCATTAGAAAATGTTGACATTGATATA
AAAATTGAGAATAACGGTATAAGAGTTAGATCTAAGGTTAAGGCTCATTATAAAACTGGAGTAGAGATGGAAGCATTAGT
TGCTACATCTATCTCCTTGTTAACTATTTGGGACATGGTTAAAAAATATGAAAAAGACGAGAACGGAAAATACCCATATA
CTATGATTAAGGATATAAAAGTTATAGATAAGATAAAAGAGAAAGACTAA

Upstream 100 bases:

>100_bases
CTAGTTGAAGTAATAGGTAGTGATAAAAAAATAGTTAGATTAAACTACTCTAACCCTAAAGTAGTAATCTTAATTAACCT
ATTGGAAGAGTTGGATAAAA

Downstream 100 bases:

>100_bases
GATTTAGACGCGGAATTAAGATACTCTTTTTCTTTAGTATTTAAACTTAACCGTTTATCATATTTCTTATAGAATATTAG
GAAGAATGGATAAGTATCAT

Product: molybdenum cofactor biosynthesis protein MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MSSEAKMVDISPKETILRVAEAEGFIKLKNDTIRRIMENEVEKGNVIAVAKTAGIMAAKKTSELLPLCHLIPLENVDIDI
KIENNGIRVRSKVKAHYKTGVEMEALVATSISLLTIWDMVKKYEKDENGKYPYTMIKDIKVIDKIKEKD

Sequences:

>Translated_149_residues
MSSEAKMVDISPKETILRVAEAEGFIKLKNDTIRRIMENEVEKGNVIAVAKTAGIMAAKKTSELLPLCHLIPLENVDIDI
KIENNGIRVRSKVKAHYKTGVEMEALVATSISLLTIWDMVKKYEKDENGKYPYTMIKDIKVIDKIKEKD
>Mature_148_residues
SSEAKMVDISPKETILRVAEAEGFIKLKNDTIRRIMENEVEKGNVIAVAKTAGIMAAKKTSELLPLCHLIPLENVDIDIK
IENNGIRVRSKVKAHYKTGVEMEALVATSISLLTIWDMVKKYEKDENGKYPYTMIKDIKVIDKIKEKD

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family [H]

Homologues:

Organism=Escherichia coli, GI1787001, Length=127, Percent_Identity=43.3070866141732, Blast_Score=112, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI32566331, Length=122, Percent_Identity=45.9016393442623, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI28574492, Length=123, Percent_Identity=42.2764227642276, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574490, Length=126, Percent_Identity=42.0634920634921, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023047
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC [H]

EC number: NA

Molecular weight: Translated: 16833; Mature: 16702

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEAKMVDISPKETILRVAEAEGFIKLKNDTIRRIMENEVEKGNVIAVAKTAGIMAAKK
CCCCCEEEECCCHHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCEEECCC
TSELLPLCHLIPLENVDIDIKIENNGIRVRSKVKAHYKTGVEMEALVATSISLLTIWDMV
HHHHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KKYEKDENGKYPYTMIKDIKVIDKIKEKD
HHHCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSEAKMVDISPKETILRVAEAEGFIKLKNDTIRRIMENEVEKGNVIAVAKTAGIMAAKK
CCCCEEEECCCHHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCEEECCC
TSELLPLCHLIPLENVDIDIKIENNGIRVRSKVKAHYKTGVEMEALVATSISLLTIWDMV
HHHHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KKYEKDENGKYPYTMIKDIKVIDKIKEKD
HHHCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]