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The map label for this gene is adhP [C]

Identifier: 227827650

GI number: 227827650

Start: 1303338

End: 1304339

Strand: Direct

Name: adhP [C]

Synonym: M1425_1378

Alternate gene names: 227827650

Gene position: 1303338-1304339 (Clockwise)

Preceding gene: 227827644

Following gene: 227827651

Centisome position: 49.96

GC content: 38.52

Gene sequence:

>1002_bases
ATGAAAGCCGTAGTAGTTCAAGGTAAGCAAAAAGGATATAGGATAGAAGAAGTTCCAGATCCAATCCCAGGAAAAGATGA
AGTTGTAATTAGGGTAAATAGAGCAGCATTATGTTATAGAGATCTATTGCAACTGCAAGGTTTTTATCCAAGAATGAAAT
ATCCAGTAATTTTAGGACATGAAGTAGTTGGTACAATAGAACAAGTTGGAGAGAACGTTAAAGGCTTTAAAGAAGGTGAT
AAGGTAATTTCGCTTCTTTATGCACCTGATGGAACTTGTCATTATTGTCAAATGGGCGAGGAAGCATATTGCCACTCCAG
GTTAGGTTATTCAGAGGAATTAGACGGCTTCTTTGCTGAAAAAGCAAAGATAAAAGTTACAAGTCTCGTAAAAGTTGGCA
CTAACGTCCCAGATGAGGGAGCGGTTTTAGTACCTTGTGTAACTGGAATGGTTTATAGAAGTTTGAGAAGGGCAAAGTTG
CAAAAGGGGGAAACAGTTCTAGTTACAGGGGCTAGTGGTGGTGTTGGTATTCATGCCATACAAATTGCTAAAGCACTTGG
TGCAAAAGTGATAGGAGTAACTACATCAGAGGAAAAAGCGGCTTTCATAAGGAAATTCGCTGACCATATAATAGTAGGTA
GTAAATTCTCAGAAGAAGCAAAGAAGATAGGCGATGTAAATGTAGTTATTGACACAGTAGGTACACCAACAATAGATGAA
AGTCTGAAAAGTTTGTGGATGGGGGGTAGGCTGATACAAATAGGTAACGTTGATCCAACTCAGATATATCAATTAAGATT
AGGATACGTCATATTGAAAGATATAGAAGTAATAGGTCATGCGTCCGCAACCAAGAGGGATGCAGAAGAAACTCTCAAGT
TAACTGGAGAAGGAAAGATAAATCCCGTAGTCGCTGCAACAGTAGGGCTAGATGAGATAGATAAGGGATATGAAATACTA
AAGGATAAGCATAAGATTGGGAAGGTACTAGTAAAGCCTTAA

Upstream 100 bases:

>100_bases
ATAATCTCTCATGGGAACGCTATACATATTATTTTTAAAAATATATCAAGTCTACTATGATAGATAATATTTTTTATACA
GTTTAAACACAATCTAACCG

Downstream 100 bases:

>100_bases
ATTTTTAAACATTTTTAAGTTATTGTGAAGCTTAAAATTTCATGGATAGAGCTTAGTCAAGATTTATTACCACATTCAGA
TTTAGATTCCGCAGAAGATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKAVVVQGKQKGYRIEEVPDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGHEVVGTIEQVGENVKGFKEGD
KVISLLYAPDGTCHYCQMGEEAYCHSRLGYSEELDGFFAEKAKIKVTSLVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKL
QKGETVLVTGASGGVGIHAIQIAKALGAKVIGVTTSEEKAAFIRKFADHIIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
SLKSLWMGGRLIQIGNVDPTQIYQLRLGYVILKDIEVIGHASATKRDAEETLKLTGEGKINPVVAATVGLDEIDKGYEIL
KDKHKIGKVLVKP

Sequences:

>Translated_333_residues
MKAVVVQGKQKGYRIEEVPDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGHEVVGTIEQVGENVKGFKEGD
KVISLLYAPDGTCHYCQMGEEAYCHSRLGYSEELDGFFAEKAKIKVTSLVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKL
QKGETVLVTGASGGVGIHAIQIAKALGAKVIGVTTSEEKAAFIRKFADHIIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
SLKSLWMGGRLIQIGNVDPTQIYQLRLGYVILKDIEVIGHASATKRDAEETLKLTGEGKINPVVAATVGLDEIDKGYEIL
KDKHKIGKVLVKP
>Mature_333_residues
MKAVVVQGKQKGYRIEEVPDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGHEVVGTIEQVGENVKGFKEGD
KVISLLYAPDGTCHYCQMGEEAYCHSRLGYSEELDGFFAEKAKIKVTSLVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKL
QKGETVLVTGASGGVGIHAIQIAKALGAKVIGVTTSEEKAAFIRKFADHIIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
SLKSLWMGGRLIQIGNVDPTQIYQLRLGYVILKDIEVIGHASATKRDAEETLKLTGEGKINPVVAATVGLDEIDKGYEIL
KDKHKIGKVLVKP

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=331, Percent_Identity=26.8882175226586, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI13236495, Length=331, Percent_Identity=26.8882175226586, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=26.9541778975741, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI156627571, Length=199, Percent_Identity=33.6683417085427, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI156523966, Length=377, Percent_Identity=26.2599469496021, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501939, Length=367, Percent_Identity=26.4305177111717, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501933, Length=228, Percent_Identity=31.140350877193, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4501929, Length=228, Percent_Identity=32.0175438596491, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI34577061, Length=228, Percent_Identity=31.140350877193, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI194239676, Length=191, Percent_Identity=31.9371727748691, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI71743840, Length=220, Percent_Identity=28.6363636363636, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI262073058, Length=220, Percent_Identity=28.6363636363636, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081918, Length=288, Percent_Identity=27.0833333333333, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790045, Length=352, Percent_Identity=25.5681818181818, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=341, Percent_Identity=26.3929618768328, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788075, Length=354, Percent_Identity=24.8587570621469, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=390, Percent_Identity=24.1025641025641, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI226510992, Length=305, Percent_Identity=26.5573770491803, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=26.6129032258064, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1790485, Length=241, Percent_Identity=27.8008298755187, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787863, Length=186, Percent_Identity=29.5698924731183, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082125, Length=269, Percent_Identity=27.1375464684015, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786518, Length=319, Percent_Identity=24.7648902821317, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788073, Length=261, Percent_Identity=26.4367816091954, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=332, Percent_Identity=26.2048192771084, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=201, Percent_Identity=29.3532338308458, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=26.2390670553936, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=221, Percent_Identity=32.1266968325792, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=218, Percent_Identity=30.2752293577982, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=258, Percent_Identity=27.5193798449612, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=229, Percent_Identity=30.1310043668122, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536829, Length=276, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=343, Percent_Identity=28.2798833819242, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=333, Percent_Identity=27.9279279279279, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324486, Length=331, Percent_Identity=28.3987915407855, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323961, Length=345, Percent_Identity=26.9565217391304, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320033, Length=239, Percent_Identity=31.3807531380753, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323980, Length=301, Percent_Identity=26.2458471760797, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=252, Percent_Identity=26.5873015873016, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=285, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=285, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=228, Percent_Identity=31.140350877193, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24581345, Length=233, Percent_Identity=27.0386266094421, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330659, Length=215, Percent_Identity=27.906976744186, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920632, Length=215, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=187, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737897, Length=187, Percent_Identity=29.9465240641711, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 36217; Mature: 36217

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00059 ADH_ZINC ; PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVVQGKQKGYRIEEVPDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGH
CCEEEEECCCCCEECCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCEEECH
EVVGTIEQVGENVKGFKEGDKVISLLYAPDGTCHYCQMGEEAYCHSRLGYSEELDGFFAE
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEHHHCCCHHHHHHHCCCCHHHCCHHHH
KAKIKVTSLVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKLQKGETVLVTGASGGVGIHAI
CCEEEEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
QIAKALGAKVIGVTTSEEKAAFIRKFADHIIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
HHHHHHCCEEEEEECCHHHHHHHHHHHHHEEECCCHHHHHHHCCCEEEEEECCCCCCHHH
SLKSLWMGGRLIQIGNVDPTQIYQLRLGYVILKDIEVIGHASATKRDAEETLKLTGEGKI
HHHHHHCCCEEEEECCCCHHHHHHHHHCCCEEEHHHHHCCCCCCCCCHHHHEEECCCCCC
NPVVAATVGLDEIDKGYEILKDKHKIGKVLVKP
CEEEEEECCHHHHHHHHHHHHHHHHHCCEEECC
>Mature Secondary Structure
MKAVVVQGKQKGYRIEEVPDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGH
CCEEEEECCCCCEECCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCEEECH
EVVGTIEQVGENVKGFKEGDKVISLLYAPDGTCHYCQMGEEAYCHSRLGYSEELDGFFAE
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEHHHCCCHHHHHHHCCCCHHHCCHHHH
KAKIKVTSLVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKLQKGETVLVTGASGGVGIHAI
CCEEEEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
QIAKALGAKVIGVTTSEEKAAFIRKFADHIIVGSKFSEEAKKIGDVNVVIDTVGTPTIDE
HHHHHHCCEEEEEECCHHHHHHHHHHHHHEEECCCHHHHHHHCCCEEEEEECCCCCCHHH
SLKSLWMGGRLIQIGNVDPTQIYQLRLGYVILKDIEVIGHASATKRDAEETLKLTGEGKI
HHHHHHCCCEEEEECCCCHHHHHHHHHCCCEEEHHHHHCCCCCCCCCHHHHEEECCCCCC
NPVVAATVGLDEIDKGYEILKDKHKIGKVLVKP
CEEEEEECCHHHHHHHHHHHHHHHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]