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The map label for this gene is thrC [H]

Identifier: 227827612

GI number: 227827612

Start: 1272121

End: 1273311

Strand: Direct

Name: thrC [H]

Synonym: M1425_1340

Alternate gene names: 227827612

Gene position: 1272121-1273311 (Clockwise)

Preceding gene: 227827610

Following gene: 227827613

Centisome position: 48.76

GC content: 36.86

Gene sequence:

>1191_bases
ATGAAGTGCTTAAGTTGTGGATATGAAACGGAAATAGATCAAGATCAGATATTATGTCCAAGATGTGGAGGACTATTGGA
AATTATAGTGGAACCACCAAAGGACTTCTCTTTCAGCAAATTGAGAGGAAGAGGAGTTTGGAGATACAAAGAACTGATAG
CAGGCAAATATAAAAATATTGTAAGTATAAATGAAGGAAATACCCCGCTAATAAGATCCTCAAATATAAATGATAATCTT
TATTTTAAATTCGAAGGACTTAATCCTACTGGAAGTTTTAAGGATAGAGGAATGACAGTAGCAGTTAGTTCTGCAGTAAG
CTTAAACTACAAAACCGTAATAGCAGCATCTACTGGAAACACTGCAGCTTCCGCAGCTGCTTATGCTGCAAGAGCAGGTA
TAAAGAGCTTTATCGTCTTACCTAAAGGTAAGGTAGCATTAGGTAAATTAGCTCAGTCAATACTTTATGGCTCAGTTATT
TTAGAGGTTGATGGAAGTTTTGACGTTGCTATGGATGCGGTAATGAGGTTATATAAGGATTTAAAAGTAGTATATCCATT
AAATTCTTTTAACCCATGGAGATTAGAAGGACAGAAGACAATAGCATTTGAGATAGCGGAAGAACTAGGAGTTCCAGATA
ATGTGATAGTCCCAGTAGGCAATGCAGGCAATATTTACGCAATATGGAAGGGATTTAATGAGCTAGTTAAAACTGGAGTG
ATAAATACTATTCCCAGAATGATTGGAATCCAAGCTGAGGGAGCATCACCAATAGCTACTGCAATAGTCAAAGGCAAAGA
TTCTCCAGATTTCGTAGAAAATCCAGATACTGTAGCCACTGCAATAAGAATAGGAAAACCAGTAAATTGGCAAAAAGCGA
TGAAAGCAATAAGAGAATCCAATGGAACCGCAATAGCGGTATCTGATTCTGAAATATTAGACGCACAGAAGACCCTAGCT
AGAAAAGAGGGCATAGGAGCTGAGCCTGCTTCAGCAGCTGCCTTAGCTGGTTACATTAAGGCAATAAATGAAAAGGTAGT
AGATAAAGATGAAAAAACAGTTTTAATCCTAACAGGACATTCATTAAAAGATCCCGATAGTATGACCAAAGCTGAAGCTA
AGAGAATATTAGTTAATCCTCTACATATGGAAAAAATTATCCTAGGTGAGATAAATGGCTCTAATAGTTAA

Upstream 100 bases:

>100_bases
ACGCCATGTGATTATTATACTTCAACAAAGCTTATATTTTGCAGAACAAACCACTTTAAACAGCTGGTGAATTGTTGTTG
GAAACACACTAAGCGGAATA

Downstream 100 bases:

>100_bases
AATAGGTGGATCAATACAAAAAGATGAAAAAGATTATGAACTTATCGTAAAGAAGATACAAGATTTTTCAAAGAAATCTG
ATAAGATCATAGTAGTAACA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKCLSCGYETEIDQDQILCPRCGGLLEIIVEPPKDFSFSKLRGRGVWRYKELIAGKYKNIVSINEGNTPLIRSSNINDNL
YFKFEGLNPTGSFKDRGMTVAVSSAVSLNYKTVIAASTGNTAASAAAYAARAGIKSFIVLPKGKVALGKLAQSILYGSVI
LEVDGSFDVAMDAVMRLYKDLKVVYPLNSFNPWRLEGQKTIAFEIAEELGVPDNVIVPVGNAGNIYAIWKGFNELVKTGV
INTIPRMIGIQAEGASPIATAIVKGKDSPDFVENPDTVATAIRIGKPVNWQKAMKAIRESNGTAIAVSDSEILDAQKTLA
RKEGIGAEPASAAALAGYIKAINEKVVDKDEKTVLILTGHSLKDPDSMTKAEAKRILVNPLHMEKIILGEINGSNS

Sequences:

>Translated_396_residues
MKCLSCGYETEIDQDQILCPRCGGLLEIIVEPPKDFSFSKLRGRGVWRYKELIAGKYKNIVSINEGNTPLIRSSNINDNL
YFKFEGLNPTGSFKDRGMTVAVSSAVSLNYKTVIAASTGNTAASAAAYAARAGIKSFIVLPKGKVALGKLAQSILYGSVI
LEVDGSFDVAMDAVMRLYKDLKVVYPLNSFNPWRLEGQKTIAFEIAEELGVPDNVIVPVGNAGNIYAIWKGFNELVKTGV
INTIPRMIGIQAEGASPIATAIVKGKDSPDFVENPDTVATAIRIGKPVNWQKAMKAIRESNGTAIAVSDSEILDAQKTLA
RKEGIGAEPASAAALAGYIKAINEKVVDKDEKTVLILTGHSLKDPDSMTKAEAKRILVNPLHMEKIILGEINGSNS
>Mature_396_residues
MKCLSCGYETEIDQDQILCPRCGGLLEIIVEPPKDFSFSKLRGRGVWRYKELIAGKYKNIVSINEGNTPLIRSSNINDNL
YFKFEGLNPTGSFKDRGMTVAVSSAVSLNYKTVIAASTGNTAASAAAYAARAGIKSFIVLPKGKVALGKLAQSILYGSVI
LEVDGSFDVAMDAVMRLYKDLKVVYPLNSFNPWRLEGQKTIAFEIAEELGVPDNVIVPVGNAGNIYAIWKGFNELVKTGV
INTIPRMIGIQAEGASPIATAIVKGKDSPDFVENPDTVATAIRIGKPVNWQKAMKAIRESNGTAIAVSDSEILDAQKTLA
RKEGIGAEPASAAALAGYIKAINEKVVDKDEKTVLILTGHSLKDPDSMTKAEAKRILVNPLHMEKIILGEINGSNS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=312, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1789505, Length=281, Percent_Identity=27.4021352313167, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790207, Length=300, Percent_Identity=28.3333333333333, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=159, Percent_Identity=33.9622641509434, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319788, Length=302, Percent_Identity=24.1721854304636, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322631, Length=299, Percent_Identity=28.0936454849498, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 42593; Mature: 42593

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCLSCGYETEIDQDQILCPRCGGLLEIIVEPPKDFSFSKLRGRGVWRYKELIAGKYKNI
CCCCCCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCHHHHCCCCCHHHHHHHHCCCCCE
VSINEGNTPLIRSSNINDNLYFKFEGLNPTGSFKDRGMTVAVSSAVSLNYKTVIAASTGN
EEECCCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCEEEEEECEEEECEEEEEEECCCC
TAASAAAYAARAGIKSFIVLPKGKVALGKLAQSILYGSVILEVDGSFDVAMDAVMRLYKD
CHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHC
LKVVYPLNSFNPWRLEGQKTIAFEIAEELGVPDNVIVPVGNAGNIYAIWKGFNELVKTGV
CEEEEECCCCCCEEECCCEEEEEEEHHHHCCCCCEEEECCCCCCEEEEEHHHHHHHHHHH
INTIPRMIGIQAEGASPIATAIVKGKDSPDFVENPDTVATAIRIGKPVNWQKAMKAIRES
HHHHHHHHEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHC
NGTAIAVSDSEILDAQKTLARKEGIGAEPASAAALAGYIKAINEKVVDKDEKTVLILTGH
CCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
SLKDPDSMTKAEAKRILVNPLHMEKIILGEINGSNS
CCCCCHHHHHHHHHHHCCCCHHEEEEEEEECCCCCC
>Mature Secondary Structure
MKCLSCGYETEIDQDQILCPRCGGLLEIIVEPPKDFSFSKLRGRGVWRYKELIAGKYKNI
CCCCCCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCHHHHCCCCCHHHHHHHHCCCCCE
VSINEGNTPLIRSSNINDNLYFKFEGLNPTGSFKDRGMTVAVSSAVSLNYKTVIAASTGN
EEECCCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCEEEEEECEEEECEEEEEEECCCC
TAASAAAYAARAGIKSFIVLPKGKVALGKLAQSILYGSVILEVDGSFDVAMDAVMRLYKD
CHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHC
LKVVYPLNSFNPWRLEGQKTIAFEIAEELGVPDNVIVPVGNAGNIYAIWKGFNELVKTGV
CEEEEECCCCCCEEECCCEEEEEEEHHHHCCCCCEEEECCCCCCEEEEEHHHHHHHHHHH
INTIPRMIGIQAEGASPIATAIVKGKDSPDFVENPDTVATAIRIGKPVNWQKAMKAIRES
HHHHHHHHEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHC
NGTAIAVSDSEILDAQKTLARKEGIGAEPASAAALAGYIKAINEKVVDKDEKTVLILTGH
CCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
SLKDPDSMTKAEAKRILVNPLHMEKIILGEINGSNS
CCCCCHHHHHHHHHHHCCCCHHEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]