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The map label for this gene is guaAA [H]

Identifier: 227826649

GI number: 227826649

Start: 207529

End: 208095

Strand: Direct

Name: guaAA [H]

Synonym: M1425_0240

Alternate gene names: 227826649

Gene position: 207529-208095 (Clockwise)

Preceding gene: 227826648

Following gene: 227826651

Centisome position: 7.95

GC content: 39.33

Gene sequence:

>567_bases
GTGAAAGTAGGTTTAGTATATTATGGCGGACAATATAATCACCTAATACTTAAGAACGTAAAGTATTTGGGAGCGGACAT
TGAGGTAACTCCCCCACATAAGCCAGTGGAGGAACTTAAGAAATTCGATTGCGTTATATTTAGTGGTGGCCCCTACTCAG
TGTCAGAGGAAATTCAAAAAATGGGAAATTCTCCCCTTTATATAAAAGAACTGAAAGTCCCAATGTTAGGCATATGCCTA
GGTCATCAGCTAATTGCCTATGTATTGGGTGGGGTTGTAAGAAGAGCCCTAAATCCAGAATACGGGCTCACTAGGATAAA
TATATTTGACGAAGATACTATTCTGAAAGGTTTCTCACAGCAACTTAACGTTTGGGAAAGTCACAATGATGAGGTGGTTG
AACCGCCTAGCGGATTCAGAGTGTTAGCTAGTAGCGCAAATGCAAGAGTCCAAGCAATGGCGAACTCAAGTAATTCAATA
TTTGGTGTGCAGTTTCATCCTGAAGTTAAACATACAGAAAGAGGAATAGAGATATTTAAGAACTTCTTAGGAGTATGTAG
AAAATAG

Upstream 100 bases:

>100_bases
ATCTATTATTGAAATGATGTCTGGTGACGGCTCTGAGCCAGTGATGTCACCAAAAAGTCTGATCAATATTTTTTAAATAT
CCAAAAACTTAGATTCTGGT

Downstream 100 bases:

>100_bases
ATTCACTTCAATTCCTCCTCAGTCTTTTTGCCACTCTCAATGATCTTTCTCTTTACCTTTTCTGGCAATGTATAATCTTC
CCTTCTTTCCTCTAATCTTC

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MKVGLVYYGGQYNHLILKNVKYLGADIEVTPPHKPVEELKKFDCVIFSGGPYSVSEEIQKMGNSPLYIKELKVPMLGICL
GHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQQLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSI
FGVQFHPEVKHTERGIEIFKNFLGVCRK

Sequences:

>Translated_188_residues
MKVGLVYYGGQYNHLILKNVKYLGADIEVTPPHKPVEELKKFDCVIFSGGPYSVSEEIQKMGNSPLYIKELKVPMLGICL
GHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQQLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSI
FGVQFHPEVKHTERGIEIFKNFLGVCRK
>Mature_188_residues
MKVGLVYYGGQYNHLILKNVKYLGADIEVTPPHKPVEELKKFDCVIFSGGPYSVSEEIQKMGNSPLYIKELKVPMLGICL
GHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQQLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSI
FGVQFHPEVKHTERGIEIFKNFLGVCRK

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=180, Percent_Identity=36.1111111111111, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI1788854, Length=197, Percent_Identity=31.4720812182741, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789760, Length=174, Percent_Identity=31.6091954022989, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI133901714, Length=194, Percent_Identity=32.4742268041237, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71992717, Length=194, Percent_Identity=32.4742268041237, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71992710, Length=194, Percent_Identity=32.4742268041237, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323873, Length=177, Percent_Identity=35.0282485875706, Blast_Score=112, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281365319, Length=184, Percent_Identity=33.1521739130435, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 21024; Mature: 21024

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGLVYYGGQYNHLILKNVKYLGADIEVTPPHKPVEELKKFDCVIFSGGPYSVSEEIQK
CEEEEEEECCCCCEEHHHHHHHHCCCCEECCCCCHHHHHHHCCEEEECCCCCCHHHHHHH
MGNSPLYIKELKVPMLGICLGHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQ
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHH
QLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSIFGVQFHPEVKHTERGIEIFK
HHHHHCCCCCCEECCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHH
NFLGVCRK
HHHHHHCC
>Mature Secondary Structure
MKVGLVYYGGQYNHLILKNVKYLGADIEVTPPHKPVEELKKFDCVIFSGGPYSVSEEIQK
CEEEEEEECCCCCEEHHHHHHHHCCCCEECCCCCHHHHHHHCCEEEECCCCCCHHHHHHH
MGNSPLYIKELKVPMLGICLGHQLIAYVLGGVVRRALNPEYGLTRINIFDEDTILKGFSQ
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHH
QLNVWESHNDEVVEPPSGFRVLASSANARVQAMANSSNSIFGVQFHPEVKHTERGIEIFK
HHHHHCCCCCCEECCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHH
NFLGVCRK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]