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The map label for this gene is adh [H]

Identifier: 227826642

GI number: 227826642

Start: 201203

End: 202189

Strand: Direct

Name: adh [H]

Synonym: M1425_0233

Alternate gene names: 227826642

Gene position: 201203-202189 (Clockwise)

Preceding gene: 227826641

Following gene: 227826645

Centisome position: 7.71

GC content: 37.39

Gene sequence:

>987_bases
ATGCTAGCTGCGATTCTAAGAAGTTTCGGTGAGGAATTAAGTCTCGAAGATGTAAGAGAGCCTTCCAATGGAATTATTCT
AAAAGTTCTAGCTACTGGGCTTTGTCATGGGGACTTGCATGTAATGAATGGCGATTGGAAATACGAAATCAAGATTGAAT
TACCGAAAATATTAGGACATGAAATTGTCGGAGAAGTTGTTAAAGGCAATCACAATTTTAAGGAAGGGGATAAGGTACTA
GTTTATAATAGTGTTGGTTGTGGAAAATGTAAGTATTGTGTGTCCAGAAAGTATCAATACTGCGAAAAAGTGAAAATTGT
TGGGCTTAATATTGATGGTGGTTTCGCGGAATATGTGAGTGTTCCTACTGATAATATTCTCTTAAGAGTAGATGGTAATC
CTGTTGAGTTAGCGCCCCTAGCAGATGCCGGAATAACAGCTTATAGCTCAACCAAGGGCATAGGTGAGGGGGATAATGTA
TTAATTATTGGAACTGGGGCTGTCGCACTATTGGCATTACAAATTTTAAAACTAAAAGGAGCTAGAATTACCGTTATTGG
GCATAATAAAAATAAACTTGGTAAGGCTAAGGAAATAGGAGCTGATGAGGTAATTGATATACAAGATGGCAGTACGATAG
CTAGTGAGATTAATGAGTCTAAGTTTGATTACATTATAGATTACGTGGGAAGTGATTACACACTTTCTGATTCCATGTGG
TTGCTAAATAGGGAAGGAGAGCTAAGAATTGTCGGAGAATTTGGTGGTACTCTAACTGTTCCGGAGCAGTTACTAGTATT
AAAGGGGTTAAAAGTAAGGGGTATATTATACGGCAACTTTGATGATTTGATAAGTGTTTATAAACTATATAATGAGGGAA
AAATTAGACCTATAGTAAATACGTACAGATTAAGGGATATCAACAAGTCGATTAAGGGTTTAAGAGAGGGCAAAGTGATA
GGCCGTGCAGTCATAGTGCCTCCTTAA

Upstream 100 bases:

>100_bases
AATCACTACTTATATTAATATCAAAAATATAGAGATAGAAGAATACGAATCAGAAATAACTGAATGGGAAAAAGAGTACT
ATTTAAAGGCAGGATGGTAA

Downstream 100 bases:

>100_bases
GATTTTTGATTTGAAAGTTGCTCTAAAAACTTCTTTAGTACCTCTACATTTTCTTCATGAACCGATTTTCTTCTTATATC
TACTATTATCCCCAGTTTTC

Product: alcohol dehydrogenase GroES domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLAAILRSFGEELSLEDVREPSNGIILKVLATGLCHGDLHVMNGDWKYEIKIELPKILGHEIVGEVVKGNHNFKEGDKVL
VYNSVGCGKCKYCVSRKYQYCEKVKIVGLNIDGGFAEYVSVPTDNILLRVDGNPVELAPLADAGITAYSSTKGIGEGDNV
LIIGTGAVALLALQILKLKGARITVIGHNKNKLGKAKEIGADEVIDIQDGSTIASEINESKFDYIIDYVGSDYTLSDSMW
LLNREGELRIVGEFGGTLTVPEQLLVLKGLKVRGILYGNFDDLISVYKLYNEGKIRPIVNTYRLRDINKSIKGLREGKVI
GRAVIVPP

Sequences:

>Translated_328_residues
MLAAILRSFGEELSLEDVREPSNGIILKVLATGLCHGDLHVMNGDWKYEIKIELPKILGHEIVGEVVKGNHNFKEGDKVL
VYNSVGCGKCKYCVSRKYQYCEKVKIVGLNIDGGFAEYVSVPTDNILLRVDGNPVELAPLADAGITAYSSTKGIGEGDNV
LIIGTGAVALLALQILKLKGARITVIGHNKNKLGKAKEIGADEVIDIQDGSTIASEINESKFDYIIDYVGSDYTLSDSMW
LLNREGELRIVGEFGGTLTVPEQLLVLKGLKVRGILYGNFDDLISVYKLYNEGKIRPIVNTYRLRDINKSIKGLREGKVI
GRAVIVPP
>Mature_328_residues
MLAAILRSFGEELSLEDVREPSNGIILKVLATGLCHGDLHVMNGDWKYEIKIELPKILGHEIVGEVVKGNHNFKEGDKVL
VYNSVGCGKCKYCVSRKYQYCEKVKIVGLNIDGGFAEYVSVPTDNILLRVDGNPVELAPLADAGITAYSSTKGIGEGDNV
LIIGTGAVALLALQILKLKGARITVIGHNKNKLGKAKEIGADEVIDIQDGSTIASEINESKFDYIIDYVGSDYTLSDSMW
LLNREGELRIVGEFGGTLTVPEQLLVLKGLKVRGILYGNFDDLISVYKLYNEGKIRPIVNTYRLRDINKSIKGLREGKVI
GRAVIVPP

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=363, Percent_Identity=28.9256198347107, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI4501933, Length=363, Percent_Identity=28.6501377410468, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=27.6881720430108, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4501929, Length=363, Percent_Identity=28.099173553719, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=26.7217630853994, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=26.5927977839335, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71743840, Length=327, Percent_Identity=26.2996941896024, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI262073058, Length=327, Percent_Identity=26.2996941896024, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI156627571, Length=318, Percent_Identity=25.1572327044025, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI226510992, Length=283, Percent_Identity=28.6219081272085, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=31.437125748503, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790045, Length=323, Percent_Identity=26.625386996904, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1786518, Length=328, Percent_Identity=27.4390243902439, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790718, Length=305, Percent_Identity=25.9016393442623, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082401, Length=323, Percent_Identity=25.3869969040248, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786825, Length=294, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788407, Length=239, Percent_Identity=30.5439330543933, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787863, Length=312, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788073, Length=244, Percent_Identity=29.0983606557377, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082125, Length=222, Percent_Identity=32.8828828828829, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=27.4193548387097, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=24.633431085044, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17565904, Length=348, Percent_Identity=28.1609195402299, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=27.2, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=341, Percent_Identity=24.0469208211144, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=335, Percent_Identity=23.2835820895522, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=340, Percent_Identity=24.4117647058824, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=192, Percent_Identity=24.4791666666667, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=321, Percent_Identity=28.0373831775701, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=334, Percent_Identity=28.4431137724551, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=25.4545454545455, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=26.0606060606061, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=24.6612466124661, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=327, Percent_Identity=30.2752293577982, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=329, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=323, Percent_Identity=24.1486068111455, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=25.6064690026954, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137530, Length=338, Percent_Identity=23.6686390532544, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17737897, Length=338, Percent_Identity=24.5562130177515, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35833; Mature: 35833

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAAILRSFGEELSLEDVREPSNGIILKVLATGLCHGDLHVMNGDWKYEIKIELPKILGH
CHHHHHHHHCCCCCHHHHCCCCCCEEEEEEEHHCCCCCEEEECCCEEEEEEEECHHHHHH
EIVGEVVKGNHNFKEGDKVLVYNSVGCGKCKYCVSRKYQYCEKVKIVGLNIDGGFAEYVS
HHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEEEEEECCCCHHEEEE
VPTDNILLRVDGNPVELAPLADAGITAYSSTKGIGEGDNVLIIGTGAVALLALQILKLKG
CCCCCEEEEECCCCEEEEECCCCCEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHCCC
ARITVIGHNKNKLGKAKEIGADEVIDIQDGSTIASEINESKFDYIIDYVGSDYTLSDSMW
CEEEEEECCCCCCCCHHHCCCCCEEEECCCCHHHHHHCCCHHHEEEEECCCCEEECCCEE
LLNREGELRIVGEFGGTLTVPEQLLVLKGLKVRGILYGNFDDLISVYKLYNEGKIRPIVN
EEECCCCEEEEEECCCEEECCHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEHH
TYRLRDINKSIKGLREGKVIGRAVIVPP
HHHHHHHHHHHHHHHCCCEEEEEEEECC
>Mature Secondary Structure
MLAAILRSFGEELSLEDVREPSNGIILKVLATGLCHGDLHVMNGDWKYEIKIELPKILGH
CHHHHHHHHCCCCCHHHHCCCCCCEEEEEEEHHCCCCCEEEECCCEEEEEEEECHHHHHH
EIVGEVVKGNHNFKEGDKVLVYNSVGCGKCKYCVSRKYQYCEKVKIVGLNIDGGFAEYVS
HHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEEEEEECCCCHHEEEE
VPTDNILLRVDGNPVELAPLADAGITAYSSTKGIGEGDNVLIIGTGAVALLALQILKLKG
CCCCCEEEEECCCCEEEEECCCCCEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHCCC
ARITVIGHNKNKLGKAKEIGADEVIDIQDGSTIASEINESKFDYIIDYVGSDYTLSDSMW
CEEEEEECCCCCCCCHHHCCCCCEEEECCCCHHHHHHCCCHHHEEEEECCCCEEECCCEE
LLNREGELRIVGEFGGTLTVPEQLLVLKGLKVRGILYGNFDDLISVYKLYNEGKIRPIVN
EEECCCCEEEEEECCCEEECCHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEHH
TYRLRDINKSIKGLREGKVIGRAVIVPP
HHHHHHHHHHHHHHHCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA