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The map label for this gene is trxB [H]

Identifier: 227826618

GI number: 227826618

Start: 180396

End: 181367

Strand: Direct

Name: trxB [H]

Synonym: M1425_0209

Alternate gene names: 227826618

Gene position: 180396-181367 (Clockwise)

Preceding gene: 227826615

Following gene: 227826619

Centisome position: 6.91

GC content: 38.58

Gene sequence:

>972_bases
ATGAGTCTTCTACCAAGAACTGCAAGTGTAAAACCGGGAGAGAAGTTCGATGTCATAATTGTTGGACTTGGTCCTGCCGC
TTATGGAGCTGCATTATATACTGCTAGATATATGCTAAAGACTCTAGTTATAGGAGAAACTCCAGGTGGGCAGTTAACTG
AAGCGGGTATAGTTGATGATTATCTTGGCTTAATAGAAATTCAAGCGAGCGATATGATAAAGGTATTTAATAAACACATA
GAGAAGTATGAGGTACCCGTCTTGTTGGATATTGTGGAGAAAATTGAAAATAGAGGAGACGGATTTGTAGTGAAAACCAA
GAGAAAAGGTGAGTTTAAGGCTGATAGCGTTATCTTAGGGATAGGAGTAAAGAGAAGAAAGTTAGGTGTACCTGGAGAAC
AAGAGTTTGTAGGAAAGGGTATATCGTACTGCTCGGTCTGCGATGCCCCATTATTTAAGAACAGAGTCGTTGCAGTTGTC
GGAGGAGGAGATTCAGCGTTAGAAGGAGCTGAGATATTATCTAGTTATTCTACTAAAGTCTATTTAATACATAGAAGAGA
TAGTTTTAAGGCGCAACCAATTTATGTTGAAACAGTTAAGAAAAAACCAAATGTTGAATTTGTACTTAATTCAGTAGTGA
AGGAAATTAAGGGAGATAAGGTTGTTAGACAAGTAGTTGTGGAGAATTTGAAAACTGGTGAGATTAAGGAGTTGAATGTA
AACGGTGTATTTGTAGAAATAGGATTTGACCCTCCAACAGATTTCGCCAAGAGCAATGGGATAGAGACTGATACAAACGG
ATATATTAAAGTAGATGAATGGATGAGGACTAGTGTACCAGGGATATTTGCAGCAGGAGACTGTACGTCAATGTGGTTGG
GGTTTAGACAAGTTATTACTTCAGTAGCTCAAGGTGCTGTGGCTGCGACTTCAGCTTATAGATATGTTACAGAAAAGAAG
GGTAAGAAATGA

Upstream 100 bases:

>100_bases
ACTTTCACACATTTATTCTAGTTTTTACGGTATTTAATTTCACGTTTTTAGAATCGTTGAACAAAACTCTTAAAATTCGC
TTACCAAATATAGTATAGCT

Downstream 100 bases:

>100_bases
TCGATTTATTAAATAAAATCGCTATCAGCGCAACAAAATATTTAAATGAAATAAAGGATGAAAAAGATCTAGATAAGGTA
GTTGGATTTCACTCAGGAGA

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSLLPRTASVKPGEKFDVIIVGLGPAAYGAALYTARYMLKTLVIGETPGGQLTEAGIVDDYLGLIEIQASDMIKVFNKHI
EKYEVPVLLDIVEKIENRGDGFVVKTKRKGEFKADSVILGIGVKRRKLGVPGEQEFVGKGISYCSVCDAPLFKNRVVAVV
GGGDSALEGAEILSSYSTKVYLIHRRDSFKAQPIYVETVKKKPNVEFVLNSVVKEIKGDKVVRQVVVENLKTGEIKELNV
NGVFVEIGFDPPTDFAKSNGIETDTNGYIKVDEWMRTSVPGIFAAGDCTSMWLGFRQVITSVAQGAVAATSAYRYVTEKK
GKK

Sequences:

>Translated_323_residues
MSLLPRTASVKPGEKFDVIIVGLGPAAYGAALYTARYMLKTLVIGETPGGQLTEAGIVDDYLGLIEIQASDMIKVFNKHI
EKYEVPVLLDIVEKIENRGDGFVVKTKRKGEFKADSVILGIGVKRRKLGVPGEQEFVGKGISYCSVCDAPLFKNRVVAVV
GGGDSALEGAEILSSYSTKVYLIHRRDSFKAQPIYVETVKKKPNVEFVLNSVVKEIKGDKVVRQVVVENLKTGEIKELNV
NGVFVEIGFDPPTDFAKSNGIETDTNGYIKVDEWMRTSVPGIFAAGDCTSMWLGFRQVITSVAQGAVAATSAYRYVTEKK
GKK
>Mature_322_residues
SLLPRTASVKPGEKFDVIIVGLGPAAYGAALYTARYMLKTLVIGETPGGQLTEAGIVDDYLGLIEIQASDMIKVFNKHIE
KYEVPVLLDIVEKIENRGDGFVVKTKRKGEFKADSVILGIGVKRRKLGVPGEQEFVGKGISYCSVCDAPLFKNRVVAVVG
GGDSALEGAEILSSYSTKVYLIHRRDSFKAQPIYVETVKKKPNVEFVLNSVVKEIKGDKVVRQVVVENLKTGEIKELNVN
GVFVEIGFDPPTDFAKSNGIETDTNGYIKVDEWMRTSVPGIFAAGDCTSMWLGFRQVITSVAQGAVAATSAYRYVTEKKG
KK

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=313, Percent_Identity=35.7827476038339, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI87081763, Length=315, Percent_Identity=33.6507936507937, Blast_Score=163, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321898, Length=317, Percent_Identity=36.5930599369085, Blast_Score=195, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6320560, Length=314, Percent_Identity=35.031847133758, Blast_Score=181, Evalue=2e-46,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 35209; Mature: 35078

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLPRTASVKPGEKFDVIIVGLGPAAYGAALYTARYMLKTLVIGETPGGQLTEAGIVDD
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCEECCCHHH
YLGLIEIQASDMIKVFNKHIEKYEVPVLLDIVEKIENRGDGFVVKTKRKGEFKADSVILG
HHCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEE
IGVKRRKLGVPGEQEFVGKGISYCSVCDAPLFKNRVVAVVGGGDSALEGAEILSSYSTKV
CCCEEEECCCCCCHHHHHCCCCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEE
YLIHRRDSFKAQPIYVETVKKKPNVEFVLNSVVKEIKGDKVVRQVVVENLKTGEIKELNV
EEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEC
NGVFVEIGFDPPTDFAKSNGIETDTNGYIKVDEWMRTSVPGIFAAGDCTSMWLGFRQVIT
CEEEEEECCCCCCCHHHCCCCCCCCCCCEEECCHHHHCCCCEEECCCHHHHHHHHHHHHH
SVAQGAVAATSAYRYVTEKKGKK
HHHHCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLLPRTASVKPGEKFDVIIVGLGPAAYGAALYTARYMLKTLVIGETPGGQLTEAGIVDD
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCEECCCHHH
YLGLIEIQASDMIKVFNKHIEKYEVPVLLDIVEKIENRGDGFVVKTKRKGEFKADSVILG
HHCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEE
IGVKRRKLGVPGEQEFVGKGISYCSVCDAPLFKNRVVAVVGGGDSALEGAEILSSYSTKV
CCCEEEECCCCCCHHHHHCCCCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEE
YLIHRRDSFKAQPIYVETVKKKPNVEFVLNSVVKEIKGDKVVRQVVVENLKTGEIKELNV
EEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEC
NGVFVEIGFDPPTDFAKSNGIETDTNGYIKVDEWMRTSVPGIFAAGDCTSMWLGFRQVIT
CEEEEEECCCCCCCHHHCCCCCCCCCCCEEECCHHHHCCCCEEECCCHHHHHHHHHHHHH
SVAQGAVAATSAYRYVTEKKGKK
HHHHCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]