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The map label for this gene is hisB

Identifier: 227815745

GI number: 227815745

Start: 2886841

End: 2887425

Strand: Reverse

Name: hisB

Synonym: BAMEG_3168

Alternate gene names: 227815745

Gene position: 2887425-2886841 (Counterclockwise)

Preceding gene: 227815746

Following gene: 227815744

Centisome position: 55.21

GC content: 38.97

Gene sequence:

>585_bases
ATGCGGGAGTCTAGTCAAATACGTGAGACGACAGAAACAAAAATAAAATTAAGTTTGCAGCTTGATGAAGGAAAGAACGT
TTCTGTACAAACGGGAGTTGGTTTTTTTGATCATATGCTAACTTTATTTGCAAGGCATGGAAGATTCGGTTTGCAAGTGG
AGGCGGAAGGCGATGTATTCGTTGATGCGCATCATACAGTTGAAGATGTTGGGATTGTACTCGGAAATTGTTTAAAAGAA
GCATTGCAAAATAAAGAGGGGATTAACCGTTACGGCTCGGCATATGTGCCGATGGACGAATCTTTAGGCTTTGTCGCAAT
TGATATTAGTGGGCGCTCATATATTGTATTTCAAGGAGAATTAACGAATCCGAAACTTGGGGATTTTGATACAGAACTAA
CAGAAGAATTTTTTAGAGCAGTTGCTCATGCCGCCAATATTACATTACATGCTCGCATTTTATATGGAAGCAATACACAT
CACAAAATTGAAGCATTATTTAAAGCGTTTGGTAGAGCGCTTAGAGAAGCAGTCGAAAGAAATGCCCACATTACTGGTGT
AAATTCAACGAAAGGGATGTTGTAA

Upstream 100 bases:

>100_bases
CATTAAGAGATGTAAAACATCATATTGTAGAACTTGCCAATAAAGAAGGGCTACATGCGCATGCGAGAGCAATTCAAATA
AGATTTGGGGAGGAAGAATA

Downstream 100 bases:

>100_bases
TTGATTGCCATTATAGATTATGGAATGGGAAATATTCGTAGTGTAGAACAAGCATTAAAATACATTGGAGCAGCGTACAT
CGTAACGAGTGATAAAGAAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRESSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNAHITGVNSTKGML

Sequences:

>Translated_194_residues
MRESSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNAHITGVNSTKGML
>Mature_194_residues
MRESSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNAHITGVNSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=44.559585492228, Blast_Score=174, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=175, Percent_Identity=42.8571428571429, Blast_Score=151, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_BACAA (C3P503)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002865919.1
- ProteinModelPortal:   C3P503
- SMR:   C3P503
- EnsemblBacteria:   EBBACT00000125940
- GeneID:   7850849
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_1494
- GeneTree:   EBGT00050000001667
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21510; Mature: 21510

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRESSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVF
CCCCHHHHHCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEE
VDAHHTVEDVGIVLGNCLKEALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGE
EECCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCEEEEEECCCEEEEEECC
LTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTHHKIEALFKAFGRALREAVER
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
NAHITGVNSTKGML
CCEEEECCCCCCCC
>Mature Secondary Structure
MRESSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVF
CCCCHHHHHCCCEEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEE
VDAHHTVEDVGIVLGNCLKEALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGE
EECCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCEEEEEECCCEEEEEECC
LTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTHHKIEALFKAFGRALREAVER
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
NAHITGVNSTKGML
CCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA