Click here to switch to the map view.

The map label for this gene is flp [H]

Identifier: 227814612

GI number: 227814612

Start: 1839331

End: 1840776

Strand: Reverse

Name: flp [H]

Synonym: BAMEG_2022

Alternate gene names: 227814612

Gene position: 1840776-1839331 (Counterclockwise)

Preceding gene: 227814613

Following gene: 227814611

Centisome position: 35.2

GC content: 30.64

Gene sequence:

>1446_bases
ATGAAGAATGCGATCTATAAAGTCTTTCTAATTTGTATTCTTTGTAATGTATTTATGCTATGTATCACACATCCAAAAGT
TTACGCTCAGCAAAATGTTAAAGTTACATTAGATAAGTATATTGAAAAATTTATAAAGGAACAGAATATTCCAGGAGCTG
CTGTTGCAATTGTACATAATAAAGAAGTATTCTTCACAAAAACGATGGGGGTTACTGGAGAATCTGAAAAAAAGGTAACT
AGTAAAACGCCATTTGCAATCGGCTCAATAAGTAAATCTTTAACAGCTTTAGCTATAGTGAAATTAATAGAAGATAAAAA
AATAAAATTAGAGGATCCAGTTCAACGATATCTCCCCTGGTTTAAACTAAAAAACCCTCAAATATCCTCAACTATAACAA
TCCAACATCTACTAACTCATACAAGCGGAATCAACACATATGAGGGCTTAGCATTATCAGATAAGCAATCCAAAAGTTCT
ACAGCATTAAAAGAAAATGTAATGAAGCTTTCAAATGTAAAAGTAACTGCTCCACCAGGTGAGAAATATCAATATAGTAA
TGCAAATTATATTGTTTTAGGTGCACTTATTGAAGAAGTCACAAATGAAACATATTCATCATATATGGAAAAGTATATTT
TTCAGCCGTTAAATATGAATGGCGCGGCAGCAAGTAAAGAAAATGCATATGAAAAAGGTTATTTAACAGGTTATCAGTCT
TGGTTTGGCATTCCAAGAAAAAGTGTAGTGTCCTATGATAATACCGGGGCACCGTATGGCTATATTACTGCAAATTTAGA
AGATATGATTCAATATATTATGTTTTTGAATCGTCCAGAGGATGCTCAATTATTAAAGCAAGAAAATATACATCTTTATC
TATCACCACTTTATAAGATAAATTCAGAAAAAAGTTATGGTTTTGGGTTAAGAACAACAAATATAAATGAAAGTGAAACG
ATGATTTGGCATTCAGGATCAACGCCCGATGCTCGTGCAGAATTATTTACTTTAAACGAAAGTGGCTGGAGTGGAGTAAT
TTTAACAAATAAAAATCATGTATTAGAAGAAACAGCACTATCAGTATTGAAAAAGGGTATTATTAGTATTTTGAATGGAG
AAGAACCGGTTGATATCCCTAAAAAAATACCATTAACACAAATTATTTTGTTGGTAGTTACACTCATACTTTTCATAATA
TCAATTATGTTAATTAAAAAGTATAAACATATGAAAACTGTAAAAAAGGTAATTTGGTTATTCATAGGGAGTCTATCCCT
ACTATTATCTATTATTTTTATTCCACTGTTTACTTATAGTACGAGTTCACCTTGGCGTACGATTAAAATATTTGCGCCAG
ACGTAGCTTTATTTACAAGTATTAGTGTAACTTTATTAGCTGTTAACGGACTAATATCAATTTTTATAGCTTTAAGAAGG
AAGTAA

Upstream 100 bases:

>100_bases
CAATGGTGGAACGCATTATTAATAATGACTAGTTTGACACTCTCTGTAGTAGTATATATTAGTTTAGTAAGTTATAAAAA
AAGAAAGCATCTAAAGTATA

Downstream 100 bases:

>100_bases
GTAGAAGGGGAAAGAATGAAAGAAATATAAGTTAAGTGTTAGAAACAGTTGACTCTCACACAATGTCATTGTTTAAGATG
AAGTTGAACTTCGAAGTAGA

Product: putative penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVT
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTAPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
WFGIPRKSVVSYDNTGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENIHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAELFTLNESGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLFTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
K

Sequences:

>Translated_481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVT
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTAPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
WFGIPRKSVVSYDNTGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENIHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAELFTLNESGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLFTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
K
>Mature_481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVT
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTAPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
WFGIPRKSVVSYDNTGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENIHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAELFTLNESGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLFTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
K

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=280, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550934, Length=338, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115533026, Length=377, Percent_Identity=24.6684350132626, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 54131; Mature: 54131

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHN
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEEEC
KEVFFTKTMGVTGESEKKVTSKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPW
CEEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
FKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAPPG
EEECCCCCCHHEEHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCEEEECCCC
EKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
CCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCHHH
WFGIPRKSVVSYDNTGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENIHLYLSPLYKI
HHCCCCHHHCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEEEEE
NSEKSYGFGLRTTNINESETMIWHSGSTPDARAELFTLNESGWSGVILTNKNHVLEETAL
CCCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHH
SVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVIWL
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIGSLSLLLSIIFIPLFTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHN
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEEEC
KEVFFTKTMGVTGESEKKVTSKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPW
CEEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
FKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAPPG
EEECCCCCCHHEEHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCEEEECCCC
EKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
CCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCHHH
WFGIPRKSVVSYDNTGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENIHLYLSPLYKI
HHCCCCHHHCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEEEEE
NSEKSYGFGLRTTNINESETMIWHSGSTPDARAELFTLNESGWSGVILTNKNHVLEETAL
CCCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHH
SVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVIWL
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIGSLSLLLSIIFIPLFTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA