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The map label for this gene is lpxH

Identifier: 227081979

GI number: 227081979

Start: 1925726

End: 1926466

Strand: Direct

Name: lpxH

Synonym: VCM66_1773

Alternate gene names: 227081979

Gene position: 1925726-1926466 (Clockwise)

Preceding gene: 227081978

Following gene: 227081980

Centisome position: 66.58

GC content: 43.32

Gene sequence:

>741_bases
ATGCATACACTATTTATTTCCGATCTTCATCTCTCCCCCAAGCATCCTGATATCACCGCTTCCTTCATTCAATTTATGCG
CGAAGAAGCCATCAAAGCTGATGCACTTTATGTCCTTGGCGACCTTTTTGATTTTTGGATTGGGGATGATGACCCAACCA
CCTTTGCCGAGCAGATTAAATCCGAGTTTCGCCAACTGACTCAACAAGGTGTGCCATGCTATTTCACTAAAGGAAATCGC
GATTTTCTGGTTGGGAAACGGTTTGCTCAACAAACAGGAGTGCAGTTGTTACCGGATGAAGCCGTGATCGACTTATATGG
GCAAAAAGCCGTCGTACTGCATGGAGATACACTCTGCACCCAAGATACACGCTACCTTGAATTTCGAGCCAAAGTACATC
AGCCTTGGTTACAGCGATTATTTGGACTTCTTCCTTTTGCACTTAAGCAAAAGCTTGTCCGCAAAATACAGTCAGACATA
CGAGATGACAAACAACATAAGTCCATGATGATCATGGATGTTACACCCAGCGAAGTCATCGCGGTTATGCATCGATATAA
CGTAGATTTAATGATTCACGGTCATACACACCGCCCTGCAATTCACTCCATTCAAACCGATGACCAGACTCTCAAAACAC
GGATTGTGTTAGGAGATTGGTATAGCCAAAGCTCGATCTTGGTCTATTCTAAACTAACTGGCTACTCATTATTGTCGAGA
CCACTCATAAATATTGAGTAA

Upstream 100 bases:

>100_bases
ATGCACCAAGATGTCCCTCTAGAGGAAGTGGTGATCACTGGCACCACTATCGAAGCTTAATTTTACTCGGAGCGCTTAGG
CGCTCCTTTTGCTGTGAAAC

Downstream 100 bases:

>100_bases
TCAATTAGTAATAACCATGTTCTTGACCAATACTTATCTCGGTAAACCCTTAAAATACTGACAAAAGAAACAACAACCCG
AAAATAGGTAAATCTTTGAA

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MHTLFISDLHLSPKHPDITASFIQFMREEAIKADALYVLGDLFDFWIGDDDPTTFAEQIKSEFRQLTQQGVPCYFTKGNR
DFLVGKRFAQQTGVQLLPDEAVIDLYGQKAVVLHGDTLCTQDTRYLEFRAKVHQPWLQRLFGLLPFALKQKLVRKIQSDI
RDDKQHKSMMIMDVTPSEVIAVMHRYNVDLMIHGHTHRPAIHSIQTDDQTLKTRIVLGDWYSQSSILVYSKLTGYSLLSR
PLINIE

Sequences:

>Translated_246_residues
MHTLFISDLHLSPKHPDITASFIQFMREEAIKADALYVLGDLFDFWIGDDDPTTFAEQIKSEFRQLTQQGVPCYFTKGNR
DFLVGKRFAQQTGVQLLPDEAVIDLYGQKAVVLHGDTLCTQDTRYLEFRAKVHQPWLQRLFGLLPFALKQKLVRKIQSDI
RDDKQHKSMMIMDVTPSEVIAVMHRYNVDLMIHGHTHRPAIHSIQTDDQTLKTRIVLGDWYSQSSILVYSKLTGYSLLSR
PLINIE
>Mature_246_residues
MHTLFISDLHLSPKHPDITASFIQFMREEAIKADALYVLGDLFDFWIGDDDPTTFAEQIKSEFRQLTQQGVPCYFTKGNR
DFLVGKRFAQQTGVQLLPDEAVIDLYGQKAVVLHGDTLCTQDTRYLEFRAKVHQPWLQRLFGLLPFALKQKLVRKIQSDI
RDDKQHKSMMIMDVTPSEVIAVMHRYNVDLMIHGHTHRPAIHSIQTDDQTLKTRIVLGDWYSQSSILVYSKLTGYSLLSR
PLINIE

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=227, Percent_Identity=48.4581497797357, Blast_Score=256, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_VIBC3 (A5F743)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F743
- STRING:   A5F743
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1441
- eggNOG:   COG2908
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- ProtClustDB:   PRK05340
- BioCyc:   VCHO345073:VC0395_A1441-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 28390; Mature: 28390

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTLFISDLHLSPKHPDITASFIQFMREEAIKADALYVLGDLFDFWIGDDDPTTFAEQIK
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SEFRQLTQQGVPCYFTKGNRDFLVGKRFAQQTGVQLLPDEAVIDLYGQKAVVLHGDTLCT
HHHHHHHHCCCCEEEECCCCEEEHHHHHHHHCCCEECCCHHHEEECCCEEEEEECCEEEC
QDTRYLEFRAKVHQPWLQRLFGLLPFALKQKLVRKIQSDIRDDKQHKSMMIMDVTPSEVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEECCHHHHH
AVMHRYNVDLMIHGHTHRPAIHSIQTDDQTLKTRIVLGDWYSQSSILVYSKLTGYSLLSR
HHHHHCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEECCCHHHHHC
PLINIE
CCCCCC
>Mature Secondary Structure
MHTLFISDLHLSPKHPDITASFIQFMREEAIKADALYVLGDLFDFWIGDDDPTTFAEQIK
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SEFRQLTQQGVPCYFTKGNRDFLVGKRFAQQTGVQLLPDEAVIDLYGQKAVVLHGDTLCT
HHHHHHHHCCCCEEEECCCCEEEHHHHHHHHCCCEECCCHHHEEECCCEEEEEECCEEEC
QDTRYLEFRAKVHQPWLQRLFGLLPFALKQKLVRKIQSDIRDDKQHKSMMIMDVTPSEVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEECCHHHHH
AVMHRYNVDLMIHGHTHRPAIHSIQTDDQTLKTRIVLGDWYSQSSILVYSKLTGYSLLSR
HHHHHCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEECCCHHHHHC
PLINIE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA