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The map label for this gene is ppiB [H]

Identifier: 227081978

GI number: 227081978

Start: 1925191

End: 1925685

Strand: Direct

Name: ppiB [H]

Synonym: VCM66_1772

Alternate gene names: 227081978

Gene position: 1925191-1925685 (Clockwise)

Preceding gene: 227081961

Following gene: 227081979

Centisome position: 66.56

GC content: 46.06

Gene sequence:

>495_bases
ATGATCACCCTGCATACCAATTTTGGTGACATCAAAATTCAGCTCAACTTTGAAAAAGCGCCAGTAACCAGCGCAAACTT
TGAGCAATATTGCCGTGAAGGTTTCTACGACAACACTCTCTTTCACCGTGTGATTGACGGCTTTATGATTCAAGGCGGCG
GTATGACTTCGGGACTGCGTGAAAAAGAGACTCGCGATCCTATTCGTAACGAAGCAAATAATGGTCTGAGCAATAAAGTG
GGTACGATTGCCATGGCGCGTACCATGGATCCTCACTCAGCGAGCTCACAATTCTTCATTAACGTGAATAACAACACTTT
CCTCGATTTTCGTTCTGAAAGTCGTGATGGTTGGGGTTACTGCGTGTTTGGTGAAGTGGTTGAAGGCATGGACATCGTTA
ATAAGATCAAGGGCGTGAGCACCGGTTCTTATGGCATGCACCAAGATGTCCCTCTAGAGGAAGTGGTGATCACTGGCACC
ACTATCGAAGCTTAA

Upstream 100 bases:

>100_bases
AACAACTCAAAGATTACTAGGTCATCCATTTGATGTTTTGAATGCACAAAAAGTTAGGCTAAACTCTGGCTCTCAATGGA
TAAATGCGAAGGTAAAACTC

Downstream 100 bases:

>100_bases
TTTTACTCGGAGCGCTTAGGCGCTCCTTTTGCTGTGAAACATGCATACACTATTTATTTCCGATCTTCATCTCTCCCCCA
AGCATCCTGATATCACCGCT

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MITLHTNFGDIKIQLNFEKAPVTSANFEQYCREGFYDNTLFHRVIDGFMIQGGGMTSGLREKETRDPIRNEANNGLSNKV
GTIAMARTMDPHSASSQFFINVNNNTFLDFRSESRDGWGYCVFGEVVEGMDIVNKIKGVSTGSYGMHQDVPLEEVVITGT
TIEA

Sequences:

>Translated_164_residues
MITLHTNFGDIKIQLNFEKAPVTSANFEQYCREGFYDNTLFHRVIDGFMIQGGGMTSGLREKETRDPIRNEANNGLSNKV
GTIAMARTMDPHSASSQFFINVNNNTFLDFRSESRDGWGYCVFGEVVEGMDIVNKIKGVSTGSYGMHQDVPLEEVVITGT
TIEA
>Mature_164_residues
MITLHTNFGDIKIQLNFEKAPVTSANFEQYCREGFYDNTLFHRVIDGFMIQGGGMTSGLREKETRDPIRNEANNGLSNKV
GTIAMARTMDPHSASSQFFINVNNNTFLDFRSESRDGWGYCVFGEVVEGMDIVNKIKGVSTGSYGMHQDVPLEEVVITGT
TIEA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=34.1463414634146, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=34.1463414634146, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=34.1463414634146, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=32.5301204819277, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI7706339, Length=162, Percent_Identity=32.0987654320988, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=31.7647058823529, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=35.6589147286822, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI5454154, Length=161, Percent_Identity=31.055900621118, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=64.8148148148148, Blast_Score=229, Evalue=9e-62,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=53.416149068323, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71980594, Length=166, Percent_Identity=32.5301204819277, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=159, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=141, Percent_Identity=34.0425531914894, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=159, Percent_Identity=31.4465408805031, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=36.6197183098592, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=165, Percent_Identity=30.3030303030303, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=158, Percent_Identity=34.8101265822785, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=145, Percent_Identity=36.551724137931, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17986117, Length=168, Percent_Identity=30.952380952381, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922376, Length=167, Percent_Identity=26.9461077844311, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=34.0740740740741, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24652460, Length=168, Percent_Identity=27.9761904761905, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18258; Mature: 18258

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLHTNFGDIKIQLNFEKAPVTSANFEQYCREGFYDNTLFHRVIDGFMIQGGGMTSGLR
CEEEECCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHHCEEEECCCCCCCCC
EKETRDPIRNEANNGLSNKVGTIAMARTMDPHSASSQFFINVNNNTFLDFRSESRDGWGY
CHHHCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCCCEE
CVFGEVVEGMDIVNKIKGVSTGSYGMHQDVPLEEVVITGTTIEA
EEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEECEEECC
>Mature Secondary Structure
MITLHTNFGDIKIQLNFEKAPVTSANFEQYCREGFYDNTLFHRVIDGFMIQGGGMTSGLR
CEEEECCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHHCEEEECCCCCCCCC
EKETRDPIRNEANNGLSNKVGTIAMARTMDPHSASSQFFINVNNNTFLDFRSESRDGWGY
CHHHCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCCCEE
CVFGEVVEGMDIVNKIKGVSTGSYGMHQDVPLEEVVITGTTIEA
EEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]