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The map label for this gene is atoC [H]

Identifier: 227081680

GI number: 227081680

Start: 1584519

End: 1585973

Strand: Reverse

Name: atoC [H]

Synonym: VCM66_1464

Alternate gene names: 227081680

Gene position: 1585973-1584519 (Counterclockwise)

Preceding gene: 227081686

Following gene: 227081679

Centisome position: 54.83

GC content: 50.79

Gene sequence:

>1455_bases
ATGTCACCAGTTTTGGATCTCAATCAAACCCATTTATATCAAGCCTTCTCTGTTTTACTTGTTGATGACGAAGTCGGTAT
GCAACTGGTACTGAAAAAAGCGCTGAGTAAATGGTTTTCGCGCGTCGATTTAGCCAGCAGCATTGAAGAGGCCGAGGTGC
TGCGTGGTGAGCATCACTACGACTTGCTGATTTTAGACATCAACCTACCGGGACGCTCAGGGATTGAATGGGAAGAAGCG
TTTACCGATCCGGATCACCGCGCGGATGTGATTTTTATGACCGGATTCGCGGATCTTGAGACCGCCATCAGCGCTCTCAA
ACTGGGGGCAAGCGATTTTATCCTCAAGCCATTTAACCTCGAACAAATGCTGCAAGCGGTGCAACGCTGTATGAATAAGC
GCCTCAATGAGCGTTTGCAGTACGCCTTGCAGCGTGATTTTCAACGCCACTGCACAACACAAATCATCGGCAGTTCAGTG
CAAACCGAATTACTCAAGCAGCGCATTGTTCAATTTGCTCCGTCGCGCGCTTCGGTGCTGATTGAAGGGGAATCGGGGAC
GGGCAAAGAGTTGGTCGCACGCGGCATCCATGAAGCGAGTGGTCGCCAAGGTCCTTTTGTGCCAATCAACTGCGGCGCGA
TTGCGCCAGAACTGCTGGAAAGTGAACTGTTTGGGCACACCTCTGGGGCATTTACCGGCGCGAAGAAGAGTCGTGAAGGG
CTGTTTCGCGTGGCTAACGGCGGCACTCTGTTTTTGGATGAAATCGGCGAAATGCCACTGACCATGCAAGCCTCGCTATT
ACGGGTTTTAGAACAACGCGCGGTGCGCCCAGTGGGTTCGGAAAAAGAGGTGAATGTGGACGTGCGAGTGGTGGCCGCCA
CCAACCGTAATCTGCAACAAGAAGTCGAAAATGGCCGTTTCCGCGGCGATCTTTACTACCGGCTTAATGTGTTGAAAATC
GAAGTGAGCCCACTGCGTGAGCGCAAGCAAGATCTGCATGAACTGTTGCCGTTTTTCACCAAAATGCTCTGTGCGGAACT
GGGGATGCCAATGCCTAAATGGGCGTATGAAGATATCTCTTCGATGCAAGACTATGATTGGCCGGGCAATATTCGCGAGT
TGAAAAACTTAATTGAGCGCTGCTTGTTATTGGGCAAACCGCCTGCGCATTATTGGCGAGAGCTCAATGGTCTGCCTATT
TATGCAGAACCCGAGGTGACAATGTCACAGAGTAATAATTCTGAAATTTCACTTGGTGACAATGTCACGCAGCCCAGCTT
GGGATATCCCAACGATTGGCCTCTGAGTGCGGTGGAAAAAGCACATATTCAGCAAATTGTGGCGCTGCATGAGGGCAATA
AATCGGCCGCCGCCCGCGATTTAGGCGTGGCACGTAAAACGTTGGAGCGTAAATACAAAGAGTGGGAAAGCGAGGATCTC
AGCCATGAAAGCTAA

Upstream 100 bases:

>100_bases
GTGACACTTTAAACCGTGTGGGACAAAATGTCGCAAATTACGCCTAGCCAATGTAAGGTTAATTGAGTCGTTCTGTCTCA
ATAAGTTATGGAATCCCTCT

Downstream 100 bases:

>100_bases
ATGGGCTTGGTGGCAAAAATGGCGACACCGTTTTCAAACCACCGTGCGCTATCGGCTGTGGATTCTGACCTCAGCGCCAA
TTTTTCTCACACTGCTGGCG

Product: sigma-54 dependent response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSPVLDLNQTHLYQAFSVLLVDDEVGMQLVLKKALSKWFSRVDLASSIEEAEVLRGEHHYDLLILDINLPGRSGIEWEEA
FTDPDHRADVIFMTGFADLETAISALKLGASDFILKPFNLEQMLQAVQRCMNKRLNERLQYALQRDFQRHCTTQIIGSSV
QTELLKQRIVQFAPSRASVLIEGESGTGKELVARGIHEASGRQGPFVPINCGAIAPELLESELFGHTSGAFTGAKKSREG
LFRVANGGTLFLDEIGEMPLTMQASLLRVLEQRAVRPVGSEKEVNVDVRVVAATNRNLQQEVENGRFRGDLYYRLNVLKI
EVSPLRERKQDLHELLPFFTKMLCAELGMPMPKWAYEDISSMQDYDWPGNIRELKNLIERCLLLGKPPAHYWRELNGLPI
YAEPEVTMSQSNNSEISLGDNVTQPSLGYPNDWPLSAVEKAHIQQIVALHEGNKSAAARDLGVARKTLERKYKEWESEDL
SHES

Sequences:

>Translated_484_residues
MSPVLDLNQTHLYQAFSVLLVDDEVGMQLVLKKALSKWFSRVDLASSIEEAEVLRGEHHYDLLILDINLPGRSGIEWEEA
FTDPDHRADVIFMTGFADLETAISALKLGASDFILKPFNLEQMLQAVQRCMNKRLNERLQYALQRDFQRHCTTQIIGSSV
QTELLKQRIVQFAPSRASVLIEGESGTGKELVARGIHEASGRQGPFVPINCGAIAPELLESELFGHTSGAFTGAKKSREG
LFRVANGGTLFLDEIGEMPLTMQASLLRVLEQRAVRPVGSEKEVNVDVRVVAATNRNLQQEVENGRFRGDLYYRLNVLKI
EVSPLRERKQDLHELLPFFTKMLCAELGMPMPKWAYEDISSMQDYDWPGNIRELKNLIERCLLLGKPPAHYWRELNGLPI
YAEPEVTMSQSNNSEISLGDNVTQPSLGYPNDWPLSAVEKAHIQQIVALHEGNKSAAARDLGVARKTLERKYKEWESEDL
SHES
>Mature_483_residues
SPVLDLNQTHLYQAFSVLLVDDEVGMQLVLKKALSKWFSRVDLASSIEEAEVLRGEHHYDLLILDINLPGRSGIEWEEAF
TDPDHRADVIFMTGFADLETAISALKLGASDFILKPFNLEQMLQAVQRCMNKRLNERLQYALQRDFQRHCTTQIIGSSVQ
TELLKQRIVQFAPSRASVLIEGESGTGKELVARGIHEASGRQGPFVPINCGAIAPELLESELFGHTSGAFTGAKKSREGL
FRVANGGTLFLDEIGEMPLTMQASLLRVLEQRAVRPVGSEKEVNVDVRVVAATNRNLQQEVENGRFRGDLYYRLNVLKIE
VSPLRERKQDLHELLPFFTKMLCAELGMPMPKWAYEDISSMQDYDWPGNIRELKNLIERCLLLGKPPAHYWRELNGLPIY
AEPEVTMSQSNNSEISLGDNVTQPSLGYPNDWPLSAVEKAHIQQIVALHEGNKSAAARDLGVARKTLERKYKEWESEDLS
HES

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=464, Percent_Identity=38.5775862068966, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1790437, Length=461, Percent_Identity=39.9132321041215, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=36.7741935483871, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI1789233, Length=325, Percent_Identity=43.0769230769231, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI1788905, Length=381, Percent_Identity=38.8451443569554, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1786524, Length=342, Percent_Identity=42.6900584795322, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082117, Length=233, Percent_Identity=49.3562231759657, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1789087, Length=263, Percent_Identity=43.7262357414449, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI87082152, Length=328, Percent_Identity=40.8536585365854, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1787583, Length=343, Percent_Identity=35.8600583090379, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI87081872, Length=222, Percent_Identity=45.945945945946, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789828, Length=215, Percent_Identity=39.0697674418605, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI87081858, Length=314, Percent_Identity=28.6624203821656, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54523; Mature: 54392

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVLDLNQTHLYQAFSVLLVDDEVGMQLVLKKALSKWFSRVDLASSIEEAEVLRGEHHY
CCCCCCCCHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
DLLILDINLPGRSGIEWEEAFTDPDHRADVIFMTGFADLETAISALKLGASDFILKPFNL
EEEEEEEECCCCCCCCHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCEECCCCH
EQMLQAVQRCMNKRLNERLQYALQRDFQRHCTTQIIGSSVQTELLKQRIVQFAPSRASVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEE
IEGESGTGKELVARGIHEASGRQGPFVPINCGAIAPELLESELFGHTSGAFTGAKKSREG
EECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHCC
LFRVANGGTLFLDEIGEMPLTMQASLLRVLEQRAVRPVGSEKEVNVDVRVVAATNRNLQQ
CEEEECCCEEEEHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHH
EVENGRFRGDLYYRLNVLKIEVSPLRERKQDLHELLPFFTKMLCAELGMPMPKWAYEDIS
HHHCCCEEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SMQDYDWPGNIRELKNLIERCLLLGKPPAHYWRELNGLPIYAEPEVTMSQSNNSEISLGD
HCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEECCCEEECCCCCCEEEECC
NVTQPSLGYPNDWPLSAVEKAHIQQIVALHEGNKSAAARDLGVARKTLERKYKEWESEDL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
SHES
CCCC
>Mature Secondary Structure 
SPVLDLNQTHLYQAFSVLLVDDEVGMQLVLKKALSKWFSRVDLASSIEEAEVLRGEHHY
CCCCCCCHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
DLLILDINLPGRSGIEWEEAFTDPDHRADVIFMTGFADLETAISALKLGASDFILKPFNL
EEEEEEEECCCCCCCCHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCEECCCCH
EQMLQAVQRCMNKRLNERLQYALQRDFQRHCTTQIIGSSVQTELLKQRIVQFAPSRASVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEE
IEGESGTGKELVARGIHEASGRQGPFVPINCGAIAPELLESELFGHTSGAFTGAKKSREG
EECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHCC
LFRVANGGTLFLDEIGEMPLTMQASLLRVLEQRAVRPVGSEKEVNVDVRVVAATNRNLQQ
CEEEECCCEEEEHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHH
EVENGRFRGDLYYRLNVLKIEVSPLRERKQDLHELLPFFTKMLCAELGMPMPKWAYEDIS
HHHCCCEEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SMQDYDWPGNIRELKNLIERCLLLGKPPAHYWRELNGLPIYAEPEVTMSQSNNSEISLGD
HCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEECCCEEECCCCCCEEEECC
NVTQPSLGYPNDWPLSAVEKAHIQQIVALHEGNKSAAARDLGVARKTLERKYKEWESEDL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
SHES
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]