BacMap

Definition	Vibrio cholerae M66-2 chromosome I, complete genome.
Accession	NC_012578
Length	2,892,523

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The map label for this gene is btuD [H]

Identifier: 227081417

GI number: 227081417

Start: 1274348

End: 1275103

Strand: Direct

Name: btuD [H]

Synonym: VCM66_1200

Alternate gene names: 227081417

Gene position: 1274348-1275103 (Clockwise)

Preceding gene: 227081416

Following gene: 227081424

Centisome position: 44.06

GC content: 50.66

Gene sequence:

>756_bases
ATGATTCGTGTTAACAGCTTACAGGTGGATTCTCGTCTGCTGCCGTTGTCATTACAGGCTAACGCTGGCGAAGTTTGGCA
TGTGATTGGCCCCAACGGCTGTGGCAAAAGCACCTTGCTTGCCGCTTTAGCGGGGATGATCCCTTTCTCTGGATCTGTGC
AGGTTGATGGGTTAGACGTGAGTCAAGCAAGCTTATCTGAACTCGCCCGCCATCGCGCTTATTTGGCACAAAATAATAAA
CCCAGCTTTCAACTGCACGTTTTCCAATATTTGGCGCTGTCGGTTCCTGCGAACGTAGCCCTAGAATGCTCGGAAGTGGC
CAGCGAAATCGATCAGATCAGCCGTTTACTCAATATTGATGACAAACTACACCGTTCGATTCACCAGCTTTCTGGTGGTG
AATGGCAGCGTGTGCGTCTAGCCGGAAGTTGTCTACAGGTCTCACCGGTTTTGAATCCTTCTGCGCGTTTACTGATTTGG
GATGAGCCAGCGGCACCCTTGGATATTGCGCAAGAAAGCCTGTTGTATCGTCTGATTGAGCGTATGGCAGGGCAGGGATT
AACGGTGATCATGGCCAATCATGACTTGAACCGCACTTTGCGTCACGCTGATCAAGTGTTACTGCTCAGTCGTGGCGTTC
TATACCGTGCTGGAAGTGCGAAAGAGGTACTGACTCAAGAAGTGCTGCAATCCGTGTTTGGCACGTCAATTCGCCGAGTG
GAACTGGAAGGGCATCCTCACTTGCTGTTCGATTGA

Upstream 100 bases:

>100_bases
CTGATTGCGCGTTTGGCGCTGGGCAGCGGCGAATTGCCATTGGGGGTAGTCACCACCACTCTGGGCGCGCCCATTTTTAT
CTGGATGTTGGTGAGAAACC

Downstream 100 bases:

>100_bases
GCCTAAGACGCCAGCATCTTATCAGGTGTTGCGTTGACCAATCATGGCGCATGGAGCACTGTTTTAGCGCATGTTGCTGG
AAGAATAGGCGAGAAAGTGT

Product: vitamin B12-transporter ATPase

Products: NA

Alternate protein names: Vitamin B12-transporting ATPase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MIRVNSLQVDSRLLPLSLQANAGEVWHVIGPNGCGKSTLLAALAGMIPFSGSVQVDGLDVSQASLSELARHRAYLAQNNK
PSFQLHVFQYLALSVPANVALECSEVASEIDQISRLLNIDDKLHRSIHQLSGGEWQRVRLAGSCLQVSPVLNPSARLLIW
DEPAAPLDIAQESLLYRLIERMAGQGLTVIMANHDLNRTLRHADQVLLLSRGVLYRAGSAKEVLTQEVLQSVFGTSIRRV
ELEGHPHLLFD

Sequences:

>Translated_251_residues
MIRVNSLQVDSRLLPLSLQANAGEVWHVIGPNGCGKSTLLAALAGMIPFSGSVQVDGLDVSQASLSELARHRAYLAQNNK
PSFQLHVFQYLALSVPANVALECSEVASEIDQISRLLNIDDKLHRSIHQLSGGEWQRVRLAGSCLQVSPVLNPSARLLIW
DEPAAPLDIAQESLLYRLIERMAGQGLTVIMANHDLNRTLRHADQVLLLSRGVLYRAGSAKEVLTQEVLQSVFGTSIRRV
ELEGHPHLLFD
>Mature_251_residues
MIRVNSLQVDSRLLPLSLQANAGEVWHVIGPNGCGKSTLLAALAGMIPFSGSVQVDGLDVSQASLSELARHRAYLAQNNK
PSFQLHVFQYLALSVPANVALECSEVASEIDQISRLLNIDDKLHRSIHQLSGGEWQRVRLAGSCLQVSPVLNPSARLLIW
DEPAAPLDIAQESLLYRLIERMAGQGLTVIMANHDLNRTLRHADQVLLLSRGVLYRAGSAKEVLTQEVLQSVFGTSIRRV
ELEGHPHLLFD

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system [H]

COG id: COG4138

COG function: function code H; ABC-type cobalamin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI45446740, Length=209, Percent_Identity=25.8373205741627, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI47078218, Length=209, Percent_Identity=25.8373205741627, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1788002, Length=239, Percent_Identity=45.1882845188285, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI1786345, Length=243, Percent_Identity=33.7448559670782, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1790739, Length=245, Percent_Identity=31.8367346938775, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081791, Length=217, Percent_Identity=30.8755760368664, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786803, Length=227, Percent_Identity=31.2775330396476, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786253, Length=212, Percent_Identity=30.188679245283, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1786398, Length=238, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787370, Length=220, Percent_Identity=25.4545454545455, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1789593, Length=223, Percent_Identity=29.5964125560538, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786698, Length=210, Percent_Identity=31.9047619047619, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787792, Length=234, Percent_Identity=27.3504273504274, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87081709, Length=219, Percent_Identity=25.5707762557078, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790190, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789032, Length=224, Percent_Identity=27.6785714285714, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787547, Length=235, Percent_Identity=28.5106382978723, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787029, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788450, Length=227, Percent_Identity=28.1938325991189, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789873, Length=208, Percent_Identity=31.7307692307692, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082268, Length=230, Percent_Identity=26.5217391304348, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786563, Length=220, Percent_Identity=28.1818181818182, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788761, Length=213, Percent_Identity=29.1079812206573, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787112, Length=217, Percent_Identity=30.8755760368664, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87081782, Length=205, Percent_Identity=26.3414634146341, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1790162, Length=223, Percent_Identity=26.9058295964126, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081834, Length=212, Percent_Identity=30.6603773584906, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789890, Length=223, Percent_Identity=28.6995515695067, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788165, Length=221, Percent_Identity=26.6968325791855, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786319, Length=212, Percent_Identity=23.5849056603774, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789991, Length=234, Percent_Identity=27.3504273504274, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789891, Length=218, Percent_Identity=27.9816513761468, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787143, Length=223, Percent_Identity=25.1121076233184, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786872, Length=192, Percent_Identity=27.6041666666667, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788225, Length=219, Percent_Identity=26.027397260274, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI48994883, Length=250, Percent_Identity=25.6, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI115535101, Length=214, Percent_Identity=29.4392523364486, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17567269, Length=221, Percent_Identity=28.5067873303167, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193208177, Length=222, Percent_Identity=31.0810810810811, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193202349, Length=217, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71983510, Length=221, Percent_Identity=28.5067873303167, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=221, Percent_Identity=28.5067873303167, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567265, Length=214, Percent_Identity=27.5700934579439, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983523, Length=221, Percent_Identity=28.5067873303167, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17541710, Length=221, Percent_Identity=25.3393665158371, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146777, Length=217, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115533608, Length=200, Percent_Identity=26.5, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539902, Length=216, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17569145, Length=232, Percent_Identity=27.1551724137931, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=248, Percent_Identity=26.6129032258064, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193211015, Length=218, Percent_Identity=26.1467889908257, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193211017, Length=218, Percent_Identity=26.1467889908257, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996809, Length=218, Percent_Identity=26.1467889908257, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71992285, Length=217, Percent_Identity=24.8847926267281, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=233, Percent_Identity=26.1802575107296, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=219, Percent_Identity=27.3972602739726, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666092, Length=198, Percent_Identity=31.3131313131313, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI85724864, Length=210, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24580555, Length=210, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85816269, Length=210, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24580553, Length=210, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574744, Length=217, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574533, Length=211, Percent_Identity=28.9099526066351, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17136662, Length=218, Percent_Identity=27.0642201834862, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221512771, Length=224, Percent_Identity=25.4464285714286, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24659289, Length=218, Percent_Identity=25.6880733944954, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.33 [H]

Molecular weight: Translated: 27531; Mature: 27531

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVNSLQVDSRLLPLSLQANAGEVWHVIGPNGCGKSTLLAALAGMIPFSGSVQVDGLDV
CEEECCEEECCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCCC
SQASLSELARHRAYLAQNNKPSFQLHVFQYLALSVPANVALECSEVASEIDQISRLLNID
CHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCC
DKLHRSIHQLSGGEWQRVRLAGSCLQVSPVLNPSARLLIWDEPAAPLDIAQESLLYRLIE
HHHHHHHHHCCCCCEEEEEEECCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
RMAGQGLTVIMANHDLNRTLRHADQVLLLSRGVLYRAGSAKEVLTQEVLQSVFGTSIRRV
HHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCEEEE
ELEGHPHLLFD
EECCCCCCCCC
>Mature Secondary Structure
MIRVNSLQVDSRLLPLSLQANAGEVWHVIGPNGCGKSTLLAALAGMIPFSGSVQVDGLDV
CEEECCEEECCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCCC
SQASLSELARHRAYLAQNNKPSFQLHVFQYLALSVPANVALECSEVASEIDQISRLLNID
CHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCC
DKLHRSIHQLSGGEWQRVRLAGSCLQVSPVLNPSARLLIWDEPAAPLDIAQESLLYRLIE
HHHHHHHHHCCCCCEEEEEEECCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
RMAGQGLTVIMANHDLNRTLRHADQVLLLSRGVLYRAGSAKEVLTQEVLQSVFGTSIRRV
HHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCEEEE
ELEGHPHLLFD
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA