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The map label for this gene is hutH

Identifier: 227081374

GI number: 227081374

Start: 1233730

End: 1235265

Strand: Reverse

Name: hutH

Synonym: VCM66_1157

Alternate gene names: 227081374

Gene position: 1235265-1233730 (Counterclockwise)

Preceding gene: 227081375

Following gene: 227081373

Centisome position: 42.71

GC content: 53.32

Gene sequence:

>1536_bases
ATGTTGCACCTGATGATCAAACCCGGCCAACTCAGCTTAAAACAGTTGCGTCAAGTGAGCCGCTCACCCGTGGTGTTATC
CCTCGATCCAGAAGCGATTCCGGCGATTGCCGAAAGCGCCCAAGTCGTCGAACAAGTGATCAGCGAAGGACGTACCGTGT
ACGGCATCAATACTGGTTTTGGTTTGCTCGCCAACACCAAAATTGCCCCGCAAGATCTGGAAACGCTGCAAAAGAGCATC
GTGCTTTCTCATGCTGCGGGCATCGGTGAGCTGATGTCGGATGAAACCGTTCGTTTGATGATGCTACTTAAAATCAACAG
CTTGGCGCGTGGCTATTCTGGTATCCGTCTTGAAGTCATCCAAGCTTTGATCGAGCTCGTCAATAACCAGATTTATCCTT
GCGTACCGAAAAAAGGCTCGGTTGGCGCATCGGGTGATCTTGCGCCGCTGGCGCACATGAGCACAGTGTTGCTCGGCGAA
GGCCAAGCCCGTTACAACGGCAAAATCATTTCCGGTCTGGAAGCGATGAAAATTGCGGGACTAGAGCCAATTACCCTCGC
CCCTAAAGAAGGGCTCGCGCTACTCAATGGCACTCAAGCCTCGACCGCATTTGCGCTCGAAGGATTGTTTGTGGCTGAAG
ATCTGTTTGCATCCGCCACTGTGTGCGGTGCGATGTCGGTCGAAGCCGCTCTGGGAAGCCGTCGCCCCTTCGATCCGCGT
ATCCACCGCGTGCGTGGGCACCGAACCCAAATGGATGCTGCAACGGCGTATCGTCACCTGCTCGATGTCAGCAGCGAAAT
TGGCCAATCCCACAGCAATTGTGAAAAAGTGCAAGATCCTTACTCTCTGCGCTGCCAACCACAAGTGATGGGCGCTTGCT
TGCAGCAAATTCGAAGTGCAGCTGAGGTGTTGGAAGTCGAAGCCAACTCTGTTTCTGATAACCCACTCGTGTTTGCCGAG
GATGGCGACATCATCTCAGGCGGCAACTTCCATGCTGAACCTGTCGCCATGGCTGCGGATAATTTGGCGCTGGCGATTGC
TGAAATCGGCAGCCTCTCCGAGCGCCGCATGGCACTGCTGATTGACAGTGCGCTGAGCAAACTACCGCCCTTTTTGGTCG
ACAATGGTGGGGTGAACTCCGGCTTTATGATTGCGCAAGTCACGGCAGCTGCCTTAGCCAGTGAGAACAAAACCCTCGCG
CATCCTGCATCAGTCGACAGTTTACCCACTTCAGCCAACCAAGAAGATCACGTTTCCATGGCGACGTTTGCCGCACGCAG
ACTGCGTGACATGGGCGAAAATACTCGTGGTATTTTGGCGGTGGAATACCTTGCAGCAGCACAAGGATTGGATTTTCGTG
CACCATTGAAGTCCTCACCACGCATTGAGGAAGCAAGGCAGATACTGCGTGAAAAAGTACCGTTTTACGATAAAGACCGC
TATTTTGCGCCGGATATCGAAAAAGCCAATGCTCTGCTGCAACTTGCCGTACACAACCGTTTAATGCCCGATCAGCTGCT
ACCAAGCCAGCACTAA

Upstream 100 bases:

>100_bases
ATGCGGGCTATGAGATTGCCAAACGCTGCGCGCAGCAACAAAAACTCGACTTACCTATGCTCAACGCTGAGCTGGCCAAA
CTCAAGTGAGGAAAGAAACC

Downstream 100 bases:

>100_bases
GTGACTGACAAATCAACATTTCAAGAGCCCTATGGGGCTCTTATACTTAAATCACTTGAAGTGGTAAAAGAACATCTCCA
CTGGATAGACCAATGATTGT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MLHLMIKPGQLSLKQLRQVSRSPVVLSLDPEAIPAIAESAQVVEQVISEGRTVYGINTGFGLLANTKIAPQDLETLQKSI
VLSHAAGIGELMSDETVRLMMLLKINSLARGYSGIRLEVIQALIELVNNQIYPCVPKKGSVGASGDLAPLAHMSTVLLGE
GQARYNGKIISGLEAMKIAGLEPITLAPKEGLALLNGTQASTAFALEGLFVAEDLFASATVCGAMSVEAALGSRRPFDPR
IHRVRGHRTQMDAATAYRHLLDVSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIRSAAEVLEVEANSVSDNPLVFAE
DGDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLA
HPASVDSLPTSANQEDHVSMATFAARRLRDMGENTRGILAVEYLAAAQGLDFRAPLKSSPRIEEARQILREKVPFYDKDR
YFAPDIEKANALLQLAVHNRLMPDQLLPSQH

Sequences:

>Translated_511_residues
MLHLMIKPGQLSLKQLRQVSRSPVVLSLDPEAIPAIAESAQVVEQVISEGRTVYGINTGFGLLANTKIAPQDLETLQKSI
VLSHAAGIGELMSDETVRLMMLLKINSLARGYSGIRLEVIQALIELVNNQIYPCVPKKGSVGASGDLAPLAHMSTVLLGE
GQARYNGKIISGLEAMKIAGLEPITLAPKEGLALLNGTQASTAFALEGLFVAEDLFASATVCGAMSVEAALGSRRPFDPR
IHRVRGHRTQMDAATAYRHLLDVSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIRSAAEVLEVEANSVSDNPLVFAE
DGDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLA
HPASVDSLPTSANQEDHVSMATFAARRLRDMGENTRGILAVEYLAAAQGLDFRAPLKSSPRIEEARQILREKVPFYDKDR
YFAPDIEKANALLQLAVHNRLMPDQLLPSQH
>Mature_511_residues
MLHLMIKPGQLSLKQLRQVSRSPVVLSLDPEAIPAIAESAQVVEQVISEGRTVYGINTGFGLLANTKIAPQDLETLQKSI
VLSHAAGIGELMSDETVRLMMLLKINSLARGYSGIRLEVIQALIELVNNQIYPCVPKKGSVGASGDLAPLAHMSTVLLGE
GQARYNGKIISGLEAMKIAGLEPITLAPKEGLALLNGTQASTAFALEGLFVAEDLFASATVCGAMSVEAALGSRRPFDPR
IHRVRGHRTQMDAATAYRHLLDVSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIRSAAEVLEVEANSVSDNPLVFAE
DGDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLA
HPASVDSLPTSANQEDHVSMATFAARRLRDMGENTRGILAVEYLAAAQGLDFRAPLKSSPRIEEARQILREKVPFYDKDR
YFAPDIEKANALLQLAVHNRLMPDQLLPSQH

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=491, Percent_Identity=45.6211812627291, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567831, Length=512, Percent_Identity=43.1640625, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_VIBCH (Q9KSQ4)

Other databases:

- EMBL:   AE003852
- PIR:   E82228
- RefSeq:   NP_230847.1
- ProteinModelPortal:   Q9KSQ4
- SMR:   Q9KSQ4
- GeneID:   2614635
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC1202
- TIGR:   VC_1202
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BRENDA:   4.3.1.3
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54818; Mature: 54818

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00488 PAL_HISTIDASE; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHLMIKPGQLSLKQLRQVSRSPVVLSLDPEAIPAIAESAQVVEQVISEGRTVYGINTGF
CEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
GLLANTKIAPQDLETLQKSIVLSHAAGIGELMSDETVRLMMLLKINSLARGYSGIRLEVI
CEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHH
QALIELVNNQIYPCVPKKGSVGASGDLAPLAHMSTVLLGEGQARYNGKIISGLEAMKIAG
HHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCHHHCHHHHHHCC
LEPITLAPKEGLALLNGTQASTAFALEGLFVAEDLFASATVCGAMSVEAALGSRRPFDPR
CCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IHRVRGHRTQMDAATAYRHLLDVSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIRSA
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
AEVLEVEANSVSDNPLVFAEDGDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALL
HHHHHHHCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCCHHHHHHHHCCCHHHHHHHH
IDSALSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLAHPASVDSLPTSANQEDHVSM
HHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
ATFAARRLRDMGENTRGILAVEYLAAAQGLDFRAPLKSSPRIEEARQILREKVPFYDKDR
HHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
YFAPDIEKANALLQLAVHNRLMPDQLLPSQH
CCCCCHHHHHHHHHHHHHCCCCCHHCCCCCC
>Mature Secondary Structure
MLHLMIKPGQLSLKQLRQVSRSPVVLSLDPEAIPAIAESAQVVEQVISEGRTVYGINTGF
CEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
GLLANTKIAPQDLETLQKSIVLSHAAGIGELMSDETVRLMMLLKINSLARGYSGIRLEVI
CEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHH
QALIELVNNQIYPCVPKKGSVGASGDLAPLAHMSTVLLGEGQARYNGKIISGLEAMKIAG
HHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCHHHCHHHHHHCC
LEPITLAPKEGLALLNGTQASTAFALEGLFVAEDLFASATVCGAMSVEAALGSRRPFDPR
CCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IHRVRGHRTQMDAATAYRHLLDVSSEIGQSHSNCEKVQDPYSLRCQPQVMGACLQQIRSA
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
AEVLEVEANSVSDNPLVFAEDGDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALL
HHHHHHHCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCCHHHHHHHHCCCHHHHHHHH
IDSALSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLAHPASVDSLPTSANQEDHVSM
HHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
ATFAARRLRDMGENTRGILAVEYLAAAQGLDFRAPLKSSPRIEEARQILREKVPFYDKDR
HHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
YFAPDIEKANALLQLAVHNRLMPDQLLPSQH
CCCCCHHHHHHHHHHHHHCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301