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The map label for this gene is hisD

Identifier: 227081306

GI number: 227081306

Start: 1159617

End: 1160912

Strand: Direct

Name: hisD

Synonym: VCM66_1089

Alternate gene names: 227081306

Gene position: 1159617-1160912 (Clockwise)

Preceding gene: 227081305

Following gene: 227081307

Centisome position: 40.09

GC content: 51.7

Gene sequence:

>1296_bases
ATGAGAACCGTGGTTTGGCAATCGTTGAGTGAAGCTCAGCAAGAATCGATTTTAGAACGTCCTGCGATTACCGAAGGAGC
AAACATCACTGCCGCAGTTGCGCAGGTGATTGCGAAAGTGCGCAGTGAGGGTGATGCCGCACTGTTTGAATTAACTGAAA
AATTTGATCGTGTAAAACCCGCTTCACTGCGCGTATCTCGCGAAGAGATGGATGCCGCGGCCGCGCGTTTGTCGGAAACA
ATGAAACAGGCGTTGGAGCAGGCATACAACAACATCAGCAAATTCCACAAGGCGCAAAAAGCGCAACCAATCAAAGTGGA
AACCATGCCCGGAGTGGTGTGTGAGCAAGTCACTCGTCCGATCAACAAAGTGGGTCTGTATATTCCGGGTGGCAGCGCAC
CGCTACCATCAACCGTACTAATGCTCGGTGTGCCTGCGCAAATCGCTGGTTGTCGTAAAGTGGTGCTCTGCTCACCTCCG
CCAATTGCTGATGAAATTCTCTACGTCGCTAAGCTGTGTAACATCGATGAGGTGTACAACCTAGGCGGCGGTCAGGCAAT
CGCCGCAATGGCTTACGGTACGGAAACGGTGACTAAAGTTGACAAAATCTTTGGCCCCGGTAACGCCTATGTGACGGAAG
CAAAACGCCAAGTGAGTAACGATTTCCGTGGCGCAGCGATTGATATGCCTGCAGGACCTTCAGAAGTATTGGTGATTGCT
GATGAAACGGCGGATGCCAATTTTATCGCCGCCGATCTACTCAGTCAGGCAGAGCACGGCCCAGATTCACAGGTGGTTCT
GGTCACACCATCACCAGTGTTGGCCGATCAAGTGACGGACGCAGTGCAAAAGCAGCTTAAAGTGCTTTCGCGCGCCAGCA
TTGCTGAAAAAGCCTTGGCTTCCAGTCTGATCATTATTGCTGAATCACTCACCCAAGCAGTGTCGATTTCTAACTACTAC
GGCCCTGAGCACTTGATTGTGCAGACGCGCAACCCGCGTGAGTTGGTTCCACTGCTCGATAACGCAGGCTCCATTTTCCT
TGGCGATTGGTCGCCAGAATCGGTAGGCGATTACGCTTCTGGTACCAACCATGTGCTACCCACTTACGGTTACACCCGCA
CCTATTCCAGCTTAGGTTTGGCCGATTTCAGTAAACGCATGACAGTGCAAGAGCTGACCGCTGATGGCTTGCAATTGCTT
GCGCCCACCGTAGTAACGATGGCGGAAGCGGAAGGGTTAGACGCGCACAAACGTGCGGTTACGATTCGAGTAGAAAAATT
ACAGAAGGCTCAATAA

Upstream 100 bases:

>100_bases
AGTTCGGAAAATCTATTCTGGGAAACCATGGAGCAGCTGAAAGCCCTCGGTGCTAGCTCAATTTTGGTGTTACCGATTGA
AAAAATGATGGAGTAAGGCG

Downstream 100 bases:

>100_bases
ATTATGGAAAAACTGGCTCGTCAACAAATTCAGGCGTTAACCCCATACCTTTCTGCGCGTCGTATTGGTGGTAGTGGTGA
TGTTTGGCTCAATGCTAACG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKPASLRVSREEMDAAAARLSET
MKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRPINKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNLGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALASSLIIIAESLTQAVSISNYY
GPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLL
APTVVTMAEAEGLDAHKRAVTIRVEKLQKAQ

Sequences:

>Translated_431_residues
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKPASLRVSREEMDAAAARLSET
MKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRPINKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNLGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALASSLIIIAESLTQAVSISNYY
GPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLL
APTVVTMAEAEGLDAHKRAVTIRVEKLQKAQ
>Mature_431_residues
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKPASLRVSREEMDAAAARLSET
MKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRPINKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNLGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALASSLIIIAESLTQAVSISNYY
GPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLL
APTVVTMAEAEGLDAHKRAVTIRVEKLQKAQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=424, Percent_Identity=63.4433962264151, Blast_Score=555, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=50.5966587112172, Blast_Score=403, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_VIBCH (Q9F854)

Other databases:

- EMBL:   AE003852
- EMBL:   AF261153
- PIR:   H82237
- RefSeq:   NP_230778.1
- ProteinModelPortal:   Q9F854
- SMR:   Q9F854
- GeneID:   2614403
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC1133
- TIGR:   VC_1133
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46127; Mature: 46127

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 323-323 ACT_SITE 324-324 BINDING 127-127 BINDING 185-185 BINDING 208-208 BINDING 234-234 BINDING 256-256 BINDING 259-259 BINDING 324-324 BINDING 357-357 BINDING 411-411 BINDING 416-416

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKP
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ASLRVSREEMDAAAARLSETMKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRP
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCC
INKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVAKLCNIDEVYN
HHHCEEEECCCCCCCCCHHEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHC
LGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCCCEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALA
ECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIIIAESLTQAVSISNYYGPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYAS
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEE
TIRVEKLQKAQ
EEEEHHHHCCC
>Mature Secondary Structure
MRTVVWQSLSEAQQESILERPAITEGANITAAVAQVIAKVRSEGDAALFELTEKFDRVKP
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ASLRVSREEMDAAAARLSETMKQALEQAYNNISKFHKAQKAQPIKVETMPGVVCEQVTRP
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCC
INKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVAKLCNIDEVYN
HHHCEEEECCCCCCCCCHHEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHC
LGGGQAIAAMAYGTETVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCCCEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADANFIAADLLSQAEHGPDSQVVLVTPSPVLADQVTDAVQKQLKVLSRASIAEKALA
ECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIIIAESLTQAVSISNYYGPEHLIVQTRNPRELVPLLDNAGSIFLGDWSPESVGDYAS
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLQLLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEE
TIRVEKLQKAQ
EEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301