Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 227081305

GI number: 227081305

Start: 1158698

End: 1159612

Strand: Direct

Name: hisG [H]

Synonym: VCM66_1088

Alternate gene names: 227081305

Gene position: 1158698-1159612 (Clockwise)

Preceding gene: 227081304

Following gene: 227081306

Centisome position: 40.06

GC content: 49.18

Gene sequence:

>915_bases
TTGCAAAGGAAGAATGACATGCAAACACAACGACTAAGAATCGCGATACAGAAAAAAGGCCGCCTGAGCCAAGAGTGCCA
AGAACTGCTGAAAAAATGCGGTGTGAAATTCAACATCATGGGCGAGCGCTTGGTGGTTCATTCACTGAATATGCCGATTG
ACCTGTTGTTGGTGCGTGACGATGACATTCCAGGACTGATCATGGATGGGGTGGTGGATTTGGGTTTTGTTGGTGAAAAC
GTGCTTGAAGAAACACGTTTAGATCGCCTAGCACTCAACCAACGTAACGAATTTACCACTCTTCGTCGTATGGACTTTGG
TGGTTGCCGTCTGTCGATCGCGATTGAAAAAGATGCTGAGTATCGTGGCCCGCAAGATCTGAATGGTAAGCGTATTGCCA
CCACCTACCCACAACTGCTCAAAGCTTATATGGATCGCCAAGGCGTGGATTTCAGCACCTGTATGTTGACGGGGTCGGTT
GAAGTTGCACCGCGCGCGGGATTAGCCGATGCGATTGCGGATCTGGTCTCCACTGGCGCGACCTTAGAAGCCAACGGTCT
TAAAGAAGTGGAAGTGATTTTTGAATCCAAAGCGACGCTTATTCAGCGCCCAGGTGCTTTTGCTGCCGATAAAGCTGCAC
TGATCGATAAACTCCTCACTCGCATGCACGGCGTGCAACAAGCCAAAGAATCGAAATACATCATGCTGCACGCTCCGGTT
GAGAAGTTGGCGCAAATCAAAACCTTGTTGCCCGGAGCGGAAGACCCAACAGTGCTTCCCTTGTCTGCCGACAAATCCAA
AGTCGCGGTACACATGGTGAGTTCGGAAAATCTATTCTGGGAAACCATGGAGCAGCTGAAAGCCCTCGGTGCTAGCTCAA
TTTTGGTGTTACCGATTGAAAAAATGATGGAGTAA

Upstream 100 bases:

>100_bases
AGTTGAAATCAGAGCCATAAAAAGATTCTAACCCTCGGGAGACCAAACCTCCCGAGGGTTTTTCGTTTTAAGCTTTGGAA
AAATTATTAAATTCAACAAA

Downstream 100 bases:

>100_bases
GGCGATGAGAACCGTGGTTTGGCAATCGTTGAGTGAAGCTCAGCAAGAATCGATTTTAGAACGTCCTGCGATTACCGAAG
GAGCAAACATCACTGCCGCA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MQRKNDMQTQRLRIAIQKKGRLSQECQELLKKCGVKFNIMGERLVVHSLNMPIDLLLVRDDDIPGLIMDGVVDLGFVGEN
VLEETRLDRLALNQRNEFTTLRRMDFGGCRLSIAIEKDAEYRGPQDLNGKRIATTYPQLLKAYMDRQGVDFSTCMLTGSV
EVAPRAGLADAIADLVSTGATLEANGLKEVEVIFESKATLIQRPGAFAADKAALIDKLLTRMHGVQQAKESKYIMLHAPV
EKLAQIKTLLPGAEDPTVLPLSADKSKVAVHMVSSENLFWETMEQLKALGASSILVLPIEKMME

Sequences:

>Translated_304_residues
MQRKNDMQTQRLRIAIQKKGRLSQECQELLKKCGVKFNIMGERLVVHSLNMPIDLLLVRDDDIPGLIMDGVVDLGFVGEN
VLEETRLDRLALNQRNEFTTLRRMDFGGCRLSIAIEKDAEYRGPQDLNGKRIATTYPQLLKAYMDRQGVDFSTCMLTGSV
EVAPRAGLADAIADLVSTGATLEANGLKEVEVIFESKATLIQRPGAFAADKAALIDKLLTRMHGVQQAKESKYIMLHAPV
EKLAQIKTLLPGAEDPTVLPLSADKSKVAVHMVSSENLFWETMEQLKALGASSILVLPIEKMME
>Mature_304_residues
MQRKNDMQTQRLRIAIQKKGRLSQECQELLKKCGVKFNIMGERLVVHSLNMPIDLLLVRDDDIPGLIMDGVVDLGFVGEN
VLEETRLDRLALNQRNEFTTLRRMDFGGCRLSIAIEKDAEYRGPQDLNGKRIATTYPQLLKAYMDRQGVDFSTCMLTGSV
EVAPRAGLADAIADLVSTGATLEANGLKEVEVIFESKATLIQRPGAFAADKAALIDKLLTRMHGVQQAKESKYIMLHAPV
EKLAQIKTLLPGAEDPTVLPLSADKSKVAVHMVSSENLFWETMEQLKALGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=68.0272108843537, Blast_Score=416, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6320896, Length=299, Percent_Identity=31.1036789297659, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 33708; Mature: 33708

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKNDMQTQRLRIAIQKKGRLSQECQELLKKCGVKFNIMGERLVVHSLNMPIDLLLVRD
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCCCEEEEEEEC
DDIPGLIMDGVVDLGFVGENVLEETRLDRLALNQRNEFTTLRRMDFGGCRLSIAIEKDAE
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEEECCCC
YRGPQDLNGKRIATTYPQLLKAYMDRQGVDFSTCMLTGSVEVAPRAGLADAIADLVSTGA
CCCCCCCCCCEEEHHHHHHHHHHHCCCCCCEEHEEEECCEEECCCCCHHHHHHHHHHCCC
TLEANGLKEVEVIFESKATLIQRPGAFAADKAALIDKLLTRMHGVQQAKESKYIMLHAPV
EEECCCCHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
EKLAQIKTLLPGAEDPTVLPLSADKSKVAVHMVSSENLFWETMEQLKALGASSILVLPIE
HHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEHH
KMME
HHCC
>Mature Secondary Structure
MQRKNDMQTQRLRIAIQKKGRLSQECQELLKKCGVKFNIMGERLVVHSLNMPIDLLLVRD
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCCCEEEEEEEC
DDIPGLIMDGVVDLGFVGENVLEETRLDRLALNQRNEFTTLRRMDFGGCRLSIAIEKDAE
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEEECCCC
YRGPQDLNGKRIATTYPQLLKAYMDRQGVDFSTCMLTGSVEVAPRAGLADAIADLVSTGA
CCCCCCCCCCEEEHHHHHHHHHHHCCCCCCEEHEEEECCEEECCCCCHHHHHHHHHHCCC
TLEANGLKEVEVIFESKATLIQRPGAFAADKAALIDKLLTRMHGVQQAKESKYIMLHAPV
EEECCCCHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
EKLAQIKTLLPGAEDPTVLPLSADKSKVAVHMVSSENLFWETMEQLKALGASSILVLPIE
HHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEHH
KMME
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]