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The map label for this gene is ywlC [H]

Identifier: 227081253

GI number: 227081253

Start: 1103696

End: 1104685

Strand: Reverse

Name: ywlC [H]

Synonym: VCM66_1035

Alternate gene names: 227081253

Gene position: 1104685-1103696 (Counterclockwise)

Preceding gene: 227081261

Following gene: 227081252

Centisome position: 38.19

GC content: 54.14

Gene sequence:

>990_bases
ATGCCGAACCACGGAGATTTTTTGTTGAATACCCAACAGCTTTCAGCGATGACACCTGCTGATATTGAATGCGCAGCTCA
GTTACTTAAGCAAGGCCAACTGGTTGCGATACCGACCGAAACCGTTTATGGACTGGCGGCCGATGCCACCCAACCTGAAG
CGGTGAAGCAGATTTTTAGTGCCAAAGGTCGCCCAGCGAATCATCCGTTGATCGTCCATCTCGGGTCGGCAGAACAACTC
TCTGAATGGGCGACCGATATTGCGCCAGAAGCGTATCAACTTGCCGAAGCTTTTTGGCCGGGGCCTTTGACGCTCTTGCT
CCCCAAAGCCAAGCAGGTTTCACCTGTTGTGACTGGCGGTTTAGAATCGGTCGGCATTCGTGTTCCCGCTCATCCTGTCT
TGCTGGATATTTTGAAGACGCATCGCTTAGCGGTGGCGGCACCTTCGGCCAACCCCTACAAAAAACTCAGCCCAACCTCA
GCCCAGCAGGTGCTTGATGGTTTGAATGGCAGACTCGCCGCAGTCTTGGATGGCGGTGAATGCCAACACGGTTTGGAATC
CACGATTGTCGATTTAACCAGCAAACCTTTTCGTGTACTGCGCGCAGGCCCGATAACGGCCAGTGAACTTAGCGCGGTAT
TGGGTCAAGAAGTACTGCAGCCACAAGTTCATCAAGTTGCGGTGCCGGGAAATGTCGATAGCCACTATCAACCGAAAACG
CGCCTACGGGTGATTGATGACCTAGCCCGTGAGCTTGCCACTCAATCGGATGAGCTTCGCATCGCGCTACTTAATCTCTC
TGCGCTGCAAGCCAGCGAGCAGCGTTTACTCAAGCCGATGCCGCAAGAAGCCAAAGCCTACGGCCAAGCCTTGTACCGCT
CTCTGGCCGAAGTGGATAAATGGGGCGTAGATGAAATTTGGTTAGAGCGTCCACCACAAGGTGAAGCGTGGCTTGCCGTG
CATGATCGGCTGCGTCGCGCAGCCAGCTAA

Upstream 100 bases:

>100_bases
AAGCATTCTTGAGTAGGGATCTGGGTCAAATTTTGTTAGAATGCCGCCCTTCAAAACACCGGACACCCTTTCATCGGTGA
ATGGATGATGCGAGTAAGTT

Downstream 100 bases:

>100_bases
GCCAATACCCACGCCGAGTACAGAGAAGAAAGGTCACCATTTTTGTGAGCTCACGCAGCAAACTAGACAACCAAACTGAG
ATGTCTGCAGATATCAGCTT

Product: hypothetical protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MPNHGDFLLNTQQLSAMTPADIECAAQLLKQGQLVAIPTETVYGLAADATQPEAVKQIFSAKGRPANHPLIVHLGSAEQL
SEWATDIAPEAYQLAEAFWPGPLTLLLPKAKQVSPVVTGGLESVGIRVPAHPVLLDILKTHRLAVAAPSANPYKKLSPTS
AQQVLDGLNGRLAAVLDGGECQHGLESTIVDLTSKPFRVLRAGPITASELSAVLGQEVLQPQVHQVAVPGNVDSHYQPKT
RLRVIDDLARELATQSDELRIALLNLSALQASEQRLLKPMPQEAKAYGQALYRSLAEVDKWGVDEIWLERPPQGEAWLAV
HDRLRRAAS

Sequences:

>Translated_329_residues
MPNHGDFLLNTQQLSAMTPADIECAAQLLKQGQLVAIPTETVYGLAADATQPEAVKQIFSAKGRPANHPLIVHLGSAEQL
SEWATDIAPEAYQLAEAFWPGPLTLLLPKAKQVSPVVTGGLESVGIRVPAHPVLLDILKTHRLAVAAPSANPYKKLSPTS
AQQVLDGLNGRLAAVLDGGECQHGLESTIVDLTSKPFRVLRAGPITASELSAVLGQEVLQPQVHQVAVPGNVDSHYQPKT
RLRVIDDLARELATQSDELRIALLNLSALQASEQRLLKPMPQEAKAYGQALYRSLAEVDKWGVDEIWLERPPQGEAWLAV
HDRLRRAAS
>Mature_328_residues
PNHGDFLLNTQQLSAMTPADIECAAQLLKQGQLVAIPTETVYGLAADATQPEAVKQIFSAKGRPANHPLIVHLGSAEQLS
EWATDIAPEAYQLAEAFWPGPLTLLLPKAKQVSPVVTGGLESVGIRVPAHPVLLDILKTHRLAVAAPSANPYKKLSPTSA
QQVLDGLNGRLAAVLDGGECQHGLESTIVDLTSKPFRVLRAGPITASELSAVLGQEVLQPQVHQVAVPGNVDSHYQPKTR
LRVIDDLARELATQSDELRIALLNLSALQASEQRLLKPMPQEAKAYGQALYRSLAEVDKWGVDEIWLERPPQGEAWLAVH
DRLRRAAS

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=182, Percent_Identity=31.8681318681319, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI2367210, Length=132, Percent_Identity=29.5454545454545, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17537239, Length=185, Percent_Identity=31.3513513513514, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321269, Length=368, Percent_Identity=30.1630434782609, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI78707274, Length=192, Percent_Identity=31.25, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 35537; Mature: 35406

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNHGDFLLNTQQLSAMTPADIECAAQLLKQGQLVAIPTETVYGLAADATQPEAVKQIFS
CCCCCCEEEEHHHHCCCCCCCHHHHHHHHHCCCEEEECCHHHHHEECCCCCHHHHHHHHH
AKGRPANHPLIVHLGSAEQLSEWATDIAPEAYQLAEAFWPGPLTLLLPKAKQVSPVVTGG
CCCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCC
LESVGIRVPAHPVLLDILKTHRLAVAAPSANPYKKLSPTSAQQVLDGLNGRLAAVLDGGE
HHHCCEECCCHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCH
CQHGLESTIVDLTSKPFRVLRAGPITASELSAVLGQEVLQPQVHQVAVPGNVDSHYQPKT
HHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCHH
RLRVIDDLARELATQSDELRIALLNLSALQASEQRLLKPMPQEAKAYGQALYRSLAEVDK
HHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
WGVDEIWLERPPQGEAWLAVHDRLRRAAS
CCCCHHHHCCCCCCCEEHHHHHHHHHHCC
>Mature Secondary Structure 
PNHGDFLLNTQQLSAMTPADIECAAQLLKQGQLVAIPTETVYGLAADATQPEAVKQIFS
CCCCCEEEEHHHHCCCCCCCHHHHHHHHHCCCEEEECCHHHHHEECCCCCHHHHHHHHH
AKGRPANHPLIVHLGSAEQLSEWATDIAPEAYQLAEAFWPGPLTLLLPKAKQVSPVVTGG
CCCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCC
LESVGIRVPAHPVLLDILKTHRLAVAAPSANPYKKLSPTSAQQVLDGLNGRLAAVLDGGE
HHHCCEECCCHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCH
CQHGLESTIVDLTSKPFRVLRAGPITASELSAVLGQEVLQPQVHQVAVPGNVDSHYQPKT
HHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCHH
RLRVIDDLARELATQSDELRIALLNLSALQASEQRLLKPMPQEAKAYGQALYRSLAEVDK
HHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
WGVDEIWLERPPQGEAWLAVHDRLRRAAS
CCCCHHHHCCCCCCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]