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The map label for this gene is cysM [C]

Identifier: 227081234

GI number: 227081234

Start: 1086336

End: 1087403

Strand: Reverse

Name: cysM [C]

Synonym: VCM66_1016

Alternate gene names: 227081234

Gene position: 1087403-1086336 (Counterclockwise)

Preceding gene: 227081236

Following gene: 227081232

Centisome position: 37.59

GC content: 50.0

Gene sequence:

>1068_bases
ATGTGTACCGACCATCAGTGGATTAACAGTGCAATTCGTAAAATTGAAGCAGACTATCAACGCTCCGCCGACACCCATCT
GATTAAACTCGATTTACCTTGCGTCTCTGGCGTCGATATCTATCTGAAAGATGAAAGTACCCACCCCACCGGTTCTCTCA
AACACCGTCTCGCCCGTTCACTGTTTTTATATGGGCTGTGTAATGGCTGGATTGGCCCAGAAACTACCATTATTGAATCC
TCATCTGGCAGTACTGCCGTATCGGAAGCTTACTTTGCTCGCTTGCTTGGCCTACCCTTTATTGCCGTGATGCCAAAGTG
CACCGCGCGTAAAAAAATCGAACAGATCCAGTTCTATGGGGGCAAGGCGCATCTTGTAGATCGCTCCGATCAAATTTACG
CAGAATCTCATCGTCTCGCGAAAGAGCTGAAAGGCCACTACATGGATCAGTTTACTTACGCTGAACGAGCCACCGACTGG
CGTGGTAACAGCAACATCGCTGACAGTATTTTTAGCCAGATGCAGATGGAACAACACCCCGTTCCAAGCTGGATTGTGAT
GAGCCCGGGGACGGGAGGCACCTCAGCCACTATCGGCCGCTTTATTCGCTACCAACAATACAACACCAAACTGTGTGTGG
TTGACCCGGAAAACTCGGTTTTTTATGACTACTACCGCACGCGAAATGCCGAGCTAACCCGTGACTGCGGCAGCAAAATT
GAAGGCATTGGCCGCCCAAGAGTCGAGCCGAGCTTTATTCCTGATGTGGTAGATGAAATGCGTGCGATCCCTGATGCCGC
GAGTGTAGCGACCATCTACTGGTTGGAGAAAATTCTTGGCCGTAAAGCAGGCGCCTCCACTGGCACTAACCTGTATGGCG
CGCTGCAACTCGCCTGCGAAATGAAGCGCCGCGGTGAGCAAGGTTCGATTGTCACGCTCTTGTGCGATAGCGGTGAACGC
TACCTTGATACCTATTACAACTCTGAGTGGGTCAAAAACAACATTGGCGATTTAAGTAAATATCTGCACAAGTTGGAAAC
ATTCTCCGCGACAGGCTGTTTGGATTAA

Upstream 100 bases:

>100_bases
AAATTTTTCTACAAAACTACAAAAGCATAGGCAAAATGGCAAAGTTTTTCTCTCCAAGCCTAGCTAAACTGATTCGGTAA
CCTAAGGGAGAAACTGGATT

Downstream 100 bases:

>100_bases
GTGCTTACTCCATGCAAACCATCCCAGCGCAAAAAGCGATGATTTAGGGATGACCATGAAAAAACGCGCTTAGCAAACTA
AGCGCGTTTTTTCATTACGG

Product: cysteine synthase/cystathionine beta-synthase family protein

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MCTDHQWINSAIRKIEADYQRSADTHLIKLDLPCVSGVDIYLKDESTHPTGSLKHRLARSLFLYGLCNGWIGPETTIIES
SSGSTAVSEAYFARLLGLPFIAVMPKCTARKKIEQIQFYGGKAHLVDRSDQIYAESHRLAKELKGHYMDQFTYAERATDW
RGNSNIADSIFSQMQMEQHPVPSWIVMSPGTGGTSATIGRFIRYQQYNTKLCVVDPENSVFYDYYRTRNAELTRDCGSKI
EGIGRPRVEPSFIPDVVDEMRAIPDAASVATIYWLEKILGRKAGASTGTNLYGALQLACEMKRRGEQGSIVTLLCDSGER
YLDTYYNSEWVKNNIGDLSKYLHKLETFSATGCLD

Sequences:

>Translated_355_residues
MCTDHQWINSAIRKIEADYQRSADTHLIKLDLPCVSGVDIYLKDESTHPTGSLKHRLARSLFLYGLCNGWIGPETTIIES
SSGSTAVSEAYFARLLGLPFIAVMPKCTARKKIEQIQFYGGKAHLVDRSDQIYAESHRLAKELKGHYMDQFTYAERATDW
RGNSNIADSIFSQMQMEQHPVPSWIVMSPGTGGTSATIGRFIRYQQYNTKLCVVDPENSVFYDYYRTRNAELTRDCGSKI
EGIGRPRVEPSFIPDVVDEMRAIPDAASVATIYWLEKILGRKAGASTGTNLYGALQLACEMKRRGEQGSIVTLLCDSGER
YLDTYYNSEWVKNNIGDLSKYLHKLETFSATGCLD
>Mature_355_residues
MCTDHQWINSAIRKIEADYQRSADTHLIKLDLPCVSGVDIYLKDESTHPTGSLKHRLARSLFLYGLCNGWIGPETTIIES
SSGSTAVSEAYFARLLGLPFIAVMPKCTARKKIEQIQFYGGKAHLVDRSDQIYAESHRLAKELKGHYMDQFTYAERATDW
RGNSNIADSIFSQMQMEQHPVPSWIVMSPGTGGTSATIGRFIRYQQYNTKLCVVDPENSVFYDYYRTRNAELTRDCGSKI
EGIGRPRVEPSFIPDVVDEMRAIPDAASVATIYWLEKILGRKAGASTGTNLYGALQLACEMKRRGEQGSIVTLLCDSGER
YLDTYYNSEWVKNNIGDLSKYLHKLETFSATGCLD

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=317, Percent_Identity=26.1829652996845, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI295821200, Length=317, Percent_Identity=26.1829652996845, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4557415, Length=317, Percent_Identity=26.1829652996845, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI2367138, Length=313, Percent_Identity=27.7955271565495, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=356, Percent_Identity=31.4606741573034, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17539800, Length=361, Percent_Identity=31.0249307479224, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17539640, Length=362, Percent_Identity=29.2817679558011, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321594, Length=335, Percent_Identity=25.0746268656716, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39911; Mature: 39911

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTDHQWINSAIRKIEADYQRSADTHLIKLDLPCVSGVDIYLKDESTHPTGSLKHRLARS
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHH
LFLYGLCNGWIGPETTIIESSSGSTAVSEAYFARLLGLPFIAVMPKCTARKKIEQIQFYG
HHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCC
GKAHLVDRSDQIYAESHRLAKELKGHYMDQFTYAERATDWRGNSNIADSIFSQMQMEQHP
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
VPSWIVMSPGTGGTSATIGRFIRYQQYNTKLCVVDPENSVFYDYYRTRNAELTRDCGSKI
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEHHHCCCCHHHHHHHHHH
EGIGRPRVEPSFIPDVVDEMRAIPDAASVATIYWLEKILGRKAGASTGTNLYGALQLACE
HCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
MKRRGEQGSIVTLLCDSGERYLDTYYNSEWVKNNIGDLSKYLHKLETFSATGCLD
HHHCCCCCCEEEEEECCCCHHHHHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MCTDHQWINSAIRKIEADYQRSADTHLIKLDLPCVSGVDIYLKDESTHPTGSLKHRLARS
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHH
LFLYGLCNGWIGPETTIIESSSGSTAVSEAYFARLLGLPFIAVMPKCTARKKIEQIQFYG
HHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCC
GKAHLVDRSDQIYAESHRLAKELKGHYMDQFTYAERATDWRGNSNIADSIFSQMQMEQHP
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
VPSWIVMSPGTGGTSATIGRFIRYQQYNTKLCVVDPENSVFYDYYRTRNAELTRDCGSKI
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEHHHCCCCHHHHHHHHHH
EGIGRPRVEPSFIPDVVDEMRAIPDAASVATIYWLEKILGRKAGASTGTNLYGALQLACE
HCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
MKRRGEQGSIVTLLCDSGERYLDTYYNSEWVKNNIGDLSKYLHKLETFSATGCLD
HHHCCCCCCEEEEEECCCCHHHHHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]