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The map label for this gene is tesB [H]

Identifier: 227081236

GI number: 227081236

Start: 1087992

End: 1088852

Strand: Reverse

Name: tesB [H]

Synonym: VCM66_1018

Alternate gene names: 227081236

Gene position: 1088852-1087992 (Counterclockwise)

Preceding gene: 227081238

Following gene: 227081234

Centisome position: 37.64

GC content: 48.66

Gene sequence:

>861_bases
ATGAGTAAACCGTTAGACGAATTATTAAGTCTGCTGCAATTGGAGAAACTGGAAGAGGGGCTGTATCGCGGTGCCAGCGA
AAATTTGGGGCTTCCTCAAGTCTATGGCGGACAAGTGATTGGCCAAGCCTTGTCGGCAGCTCGCTACACGGTCGAGTCAG
ATCGCACTGTGCACTCTTTCCATAGCTATTTTCTTTACCCTGGCGATCCAGAAAAACCGATTATTTACGATGTAGAAAAT
CTTCGTGATGGCAAAAGCTTCAGCACTCGCCGTGTTAAAGCGATCCAAAATGGTCGGCCAATTTTTTATCTGACTGCGTC
CTACCATGGTGATGCACCGGGATTTGAGCACCAAAAAACCATGCCTGTGGTTCCAGGGCCAGAGAACTTTGCTTCCGAAT
CCGAACTCGCGGCGCAGATTGCGCATTTCTTACCAGAAAAACTGCAAAAAGCGTTTTGTGGTGAAAAACCGATTGAGATG
CGTCCCGTTACTGTCATCAACCCCTTGAAGCCAGAAAAAGCGGAGCCTAAGCAGTATTTGTGGATCCGAGCCAATGGCGA
TATGCCCGATGACCAGCTCATCCATCAGTATTTGCTTGGCTATGCGTCTGACTGGGGCTTTTTAGTGACCGCCTTGCATC
CACACGGTGTTTCTCTGATGACACCAAAATTCCAAGTGGCAACCATTGACCACTCTATCTGGTTCCACCGTCCGTTTAAG
ATGGATGACTGGCTACTGTTTGCCATCGAAAGTCCTACGGCGAGCAATACACGTGGTTTAGTGCGTGGTGAGATTTATGA
TCGCCAAGGCAATTTGGTCGCAACAGCCGTCCAAGAAGGCGTTATGCGCTTTTTAAGCTGA

Upstream 100 bases:

>100_bases
ATATGCCACCACGGTATTTGTGTCATTGGACAGCAGGATTATTGACAAATGTCTGACTAACATCACAAAATCATCAAACT
ACAAAAGAGGGTCCTAAGTC

Downstream 100 bases:

>100_bases
TCTCACCCTTAGAGCGGTAACTGAGTCGTGTATTTAAGTGACTCCATCGCAAAGGTGGAGGTCACTTTGTTCAACCCTTC
GATACTATTGACCAGTTTTT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSKPLDELLSLLQLEKLEEGLYRGASENLGLPQVYGGQVIGQALSAARYTVESDRTVHSFHSYFLYPGDPEKPIIYDVEN
LRDGKSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQKTMPVVPGPENFASESELAAQIAHFLPEKLQKAFCGEKPIEM
RPVTVINPLKPEKAEPKQYLWIRANGDMPDDQLIHQYLLGYASDWGFLVTALHPHGVSLMTPKFQVATIDHSIWFHRPFK
MDDWLLFAIESPTASNTRGLVRGEIYDRQGNLVATAVQEGVMRFLS

Sequences:

>Translated_286_residues
MSKPLDELLSLLQLEKLEEGLYRGASENLGLPQVYGGQVIGQALSAARYTVESDRTVHSFHSYFLYPGDPEKPIIYDVEN
LRDGKSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQKTMPVVPGPENFASESELAAQIAHFLPEKLQKAFCGEKPIEM
RPVTVINPLKPEKAEPKQYLWIRANGDMPDDQLIHQYLLGYASDWGFLVTALHPHGVSLMTPKFQVATIDHSIWFHRPFK
MDDWLLFAIESPTASNTRGLVRGEIYDRQGNLVATAVQEGVMRFLS
>Mature_285_residues
SKPLDELLSLLQLEKLEEGLYRGASENLGLPQVYGGQVIGQALSAARYTVESDRTVHSFHSYFLYPGDPEKPIIYDVENL
RDGKSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQKTMPVVPGPENFASESELAAQIAHFLPEKLQKAFCGEKPIEMR
PVTVINPLKPEKAEPKQYLWIRANGDMPDDQLIHQYLLGYASDWGFLVTALHPHGVSLMTPKFQVATIDHSIWFHRPFKM
DDWLLFAIESPTASNTRGLVRGEIYDRQGNLVATAVQEGVMRFLS

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=284, Percent_Identity=41.1971830985916, Blast_Score=212, Evalue=3e-55,
Organism=Escherichia coli, GI1786657, Length=269, Percent_Identity=62.0817843866171, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71988741, Length=293, Percent_Identity=36.8600682593857, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17558508, Length=301, Percent_Identity=37.8737541528239, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17531889, Length=268, Percent_Identity=34.7014925373134, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI115532456, Length=268, Percent_Identity=34.7014925373134, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17531885, Length=268, Percent_Identity=34.7014925373134, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71982224, Length=298, Percent_Identity=29.1946308724832, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI212645202, Length=284, Percent_Identity=30.2816901408451, Blast_Score=117, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32231; Mature: 32100

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLDELLSLLQLEKLEEGLYRGASENLGLPQVYGGQVIGQALSAARYTVESDRTVHSF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCHHHHHHHHHHHHEECCCCCEEEHH
HSYFLYPGDPEKPIIYDVENLRDGKSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQKT
HCEEEECCCCCCCEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
MPVVPGPENFASESELAAQIAHFLPEKLQKAFCGEKPIEMRPVTVINPLKPEKAEPKQYL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEE
WIRANGDMPDDQLIHQYLLGYASDWGFLVTALHPHGVSLMTPKFQVATIDHSIWFHRPFK
EEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCEEEEEEECCEEEECCCC
MDDWLLFAIESPTASNTRGLVRGEIYDRQGNLVATAVQEGVMRFLS
CCCEEEEEECCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHCC
>Mature Secondary Structure 
SKPLDELLSLLQLEKLEEGLYRGASENLGLPQVYGGQVIGQALSAARYTVESDRTVHSF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCHHHHHHHHHHHHEECCCCCEEEHH
HSYFLYPGDPEKPIIYDVENLRDGKSFSTRRVKAIQNGRPIFYLTASYHGDAPGFEHQKT
HCEEEECCCCCCCEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
MPVVPGPENFASESELAAQIAHFLPEKLQKAFCGEKPIEMRPVTVINPLKPEKAEPKQYL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEE
WIRANGDMPDDQLIHQYLLGYASDWGFLVTALHPHGVSLMTPKFQVATIDHSIWFHRPFK
EEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCEEEEEEECCEEEECCCC
MDDWLLFAIESPTASNTRGLVRGEIYDRQGNLVATAVQEGVMRFLS
CCCEEEEEECCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]