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The map label for this gene is epd [H]

Identifier: 227080686

GI number: 227080686

Start: 491549

End: 492706

Strand: Direct

Name: epd [H]

Synonym: VCM66_0461

Alternate gene names: 227080686

Gene position: 491549-492706 (Clockwise)

Preceding gene: 227080685

Following gene: 227080687

Centisome position: 16.99

GC content: 46.37

Gene sequence:

>1158_bases
TTGGCGGCAGCGCCAATCCTCTGTGTGTTTCGCGATCGGCGGTGGAATCATTTATTGCACAGGATCGCCGTGCCAAAGCT
TAGAGTATCGGTTACTATTGCCAAACAATCTGATAGCGATAGGCGAGATACGATGCTGAGGGTAGCAATTAACGGCTTTG
GGCGCATTGGGCGTAACGTATTACGTGCAGTGTATGAAAGTGGTAAACGTGACCGCATTCAAGTGGTTGCGGTGAACGAG
CTTGCCAAGCCAGATGCGATGGCGCACCTCCTGCAGTACGATACTAGCCACGGTCGCTTTGGCAAAAAAATCAGCCATGA
TCAGCAGCATATCTATGTTCACCATCAAAATGGTGAGTATGACTCAATCCGCATTCTGCATCTTTCGGAAATTCCTCTCT
TACCTTGGCGTGATTTAGGCGTGGATTTAGTCCTCGACTGTACAGGTGTGTATGGTTGCCAAGAGGATGGTCAGCAACAT
ATTGATGCGGGCGCGAAGTTAGTTTTATTTTCCCATCCTGGTGCTAGCGATCTCGACAACACCATCATCTATGGCGTGAA
TCATGAGACGCTCACTGCTGAGCATAAAATCGTCTCTAACGGTTCTTGTACCACCAACTGCATTGTGCCCATCATCAAGG
TATTGGATGACGCATTCGGCATTGATTCTGGCACCATCACCACCATCCATTCCTCGATGAACGATCAACAAGTGATTGAT
GCGTATCATAATGACTTACGACGCACACGAGCGGCCAGTCAATCGATCATTCCGGTTGATACTAAGTTGCATAAAGGTAT
TGAAAGAATATTTCCGAAATTTTCTAACAAATTTGAAGCGATTTCGGTGCGTGTACCAACAGTAAATGTGACCGCGATGG
ATTTAAGTGTCACAATTAAATCAAATGTGAAAGTTAATGACGTAAATCAAACCATTGTGAACGCATCTCAGTGTACATTA
CGTGGCATTGTTGACTATACTGAAGCGCCTTTGGTTTCCATCGATTTTAACCACGATCCGCACAGCGCGATTGTGGATGG
GACACAAACGAGAGTCAGTAACGGGCAGTTAGTAAAAATGCTCGTTTGGTGTGATAACGAATGGGGCTTTGCCAACCGGA
TGTTAGATACCGCATTGGCAATGCAGGCCACGCAGTAG

Upstream 100 bases:

>100_bases
GATCAAGAGGTGAATTACGCGGAGTATGGCTATGTAGAAGATGGCCGCCGCTACTGGTTGGGCTTAGACATCGCCTTCTA
ATTGCTAGAGGTTTAGAGGA

Downstream 100 bases:

>100_bases
CGGCTAAGCATGCACTTCAAATCAGGTTTGAACATTGAAACCCGAAGGACGTATCCCCATATCGGTAAACAGCTAAGATT
TTACCGACTCGGCAGGGTCG

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MAAAPILCVFRDRRWNHLLHRIAVPKLRVSVTIAKQSDSDRRDTMLRVAINGFGRIGRNVLRAVYESGKRDRIQVVAVNE
LAKPDAMAHLLQYDTSHGRFGKKISHDQQHIYVHHQNGEYDSIRILHLSEIPLLPWRDLGVDLVLDCTGVYGCQEDGQQH
IDAGAKLVLFSHPGASDLDNTIIYGVNHETLTAEHKIVSNGSCTTNCIVPIIKVLDDAFGIDSGTITTIHSSMNDQQVID
AYHNDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTIKSNVKVNDVNQTIVNASQCTL
RGIVDYTEAPLVSIDFNHDPHSAIVDGTQTRVSNGQLVKMLVWCDNEWGFANRMLDTALAMQATQ

Sequences:

>Translated_385_residues
MAAAPILCVFRDRRWNHLLHRIAVPKLRVSVTIAKQSDSDRRDTMLRVAINGFGRIGRNVLRAVYESGKRDRIQVVAVNE
LAKPDAMAHLLQYDTSHGRFGKKISHDQQHIYVHHQNGEYDSIRILHLSEIPLLPWRDLGVDLVLDCTGVYGCQEDGQQH
IDAGAKLVLFSHPGASDLDNTIIYGVNHETLTAEHKIVSNGSCTTNCIVPIIKVLDDAFGIDSGTITTIHSSMNDQQVID
AYHNDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTIKSNVKVNDVNQTIVNASQCTL
RGIVDYTEAPLVSIDFNHDPHSAIVDGTQTRVSNGQLVKMLVWCDNEWGFANRMLDTALAMQATQ
>Mature_384_residues
AAAPILCVFRDRRWNHLLHRIAVPKLRVSVTIAKQSDSDRRDTMLRVAINGFGRIGRNVLRAVYESGKRDRIQVVAVNEL
AKPDAMAHLLQYDTSHGRFGKKISHDQQHIYVHHQNGEYDSIRILHLSEIPLLPWRDLGVDLVLDCTGVYGCQEDGQQHI
DAGAKLVLFSHPGASDLDNTIIYGVNHETLTAEHKIVSNGSCTTNCIVPIIKVLDDAFGIDSGTITTIHSSMNDQQVIDA
YHNDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTIKSNVKVNDVNQTIVNASQCTLR
GIVDYTEAPLVSIDFNHDPHSAIVDGTQTRVSNGQLVKMLVWCDNEWGFANRMLDTALAMQATQ

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=346, Percent_Identity=36.7052023121387, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI7657116, Length=334, Percent_Identity=35.6287425149701, Blast_Score=214, Evalue=2e-55,
Organism=Escherichia coli, GI1789295, Length=336, Percent_Identity=69.6428571428571, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1788079, Length=334, Percent_Identity=37.4251497005988, Blast_Score=238, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17534677, Length=332, Percent_Identity=37.3493975903614, Blast_Score=240, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17534679, Length=332, Percent_Identity=37.0481927710843, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32566163, Length=336, Percent_Identity=37.202380952381, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17568413, Length=332, Percent_Identity=37.3493975903614, Blast_Score=233, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322409, Length=336, Percent_Identity=39.2857142857143, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322468, Length=334, Percent_Identity=38.9221556886228, Blast_Score=255, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6321631, Length=334, Percent_Identity=39.2215568862275, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI19922412, Length=340, Percent_Identity=36.1764705882353, Blast_Score=227, Evalue=8e-60,
Organism=Drosophila melanogaster, GI85725000, Length=341, Percent_Identity=34.6041055718475, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI22023983, Length=341, Percent_Identity=34.6041055718475, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI17933600, Length=341, Percent_Identity=34.0175953079179, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI18110149, Length=341, Percent_Identity=34.0175953079179, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.72 [H]

Molecular weight: Translated: 42869; Mature: 42738

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAPILCVFRDRRWNHLLHRIAVPKLRVSVTIAKQSDSDRRDTMLRVAINGFGRIGRNV
CCCCCEEEEEECCHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHEEEEEEHHHHHHHHHH
LRAVYESGKRDRIQVVAVNELAKPDAMAHLLQYDTSHGRFGKKISHDQQHIYVHHQNGEY
HHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCC
DSIRILHLSEIPLLPWRDLGVDLVLDCTGVYGCQEDGQQHIDAGAKLVLFSHPGASDLDN
CCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCC
TIIYGVNHETLTAEHKIVSNGSCTTNCIVPIIKVLDDAFGIDSGTITTIHSSMNDQQVID
CEEEECCCCEEEECEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
AYHNDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTIK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECEEEEEEEEEEEEEE
SNVKVNDVNQTIVNASQCTLRGIVDYTEAPLVSIDFNHDPHSAIVDGTQTRVSNGQLVKM
CCEEEECCHHHHHCCCHHEEEEHHCCCCCCEEEEECCCCCCCCEECCCCEECCCCCEEEE
LVWCDNEWGFANRMLDTALAMQATQ
EEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAAPILCVFRDRRWNHLLHRIAVPKLRVSVTIAKQSDSDRRDTMLRVAINGFGRIGRNV
CCCCEEEEEECCHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHEEEEEEHHHHHHHHHH
LRAVYESGKRDRIQVVAVNELAKPDAMAHLLQYDTSHGRFGKKISHDQQHIYVHHQNGEY
HHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCC
DSIRILHLSEIPLLPWRDLGVDLVLDCTGVYGCQEDGQQHIDAGAKLVLFSHPGASDLDN
CCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCC
TIIYGVNHETLTAEHKIVSNGSCTTNCIVPIIKVLDDAFGIDSGTITTIHSSMNDQQVID
CEEEECCCCEEEECEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
AYHNDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTIK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECEEEEEEEEEEEEEE
SNVKVNDVNQTIVNASQCTLRGIVDYTEAPLVSIDFNHDPHSAIVDGTQTRVSNGQLVKM
CCEEEECCHHHHHCCCHHEEEEHHCCCCCCEEEEECCCCCCCCEECCCCEECCCCCEEEE
LVWCDNEWGFANRMLDTALAMQATQ
EEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA