Click here to switch to the map view.

The map label for this gene is irgA [H]

Identifier: 227080685

GI number: 227080685

Start: 489571

End: 491529

Strand: Direct

Name: irgA [H]

Synonym: VCM66_0460

Alternate gene names: 227080685

Gene position: 489571-491529 (Clockwise)

Preceding gene: 227080683

Following gene: 227080686

Centisome position: 16.93

GC content: 49.82

Gene sequence:

>1959_bases
ATGTCCAGATTCAATCCATCCCCCGTCAGTTTATCTGTGACACTAGGCTTAATGTTTTCGGCTAGCGCTTTTGCTCAAGA
CGCGACGAAAACGGATGAAACCATGGTGGTCACTGCGGCGGGATACGCGCAAGTGATTCAAAATGCGCCAGCCAGTATCA
GTGTGATTTCAAGAGAAGATCTGGAATCTCGCTATTACCGTGATGTGACCGATGCGCTAAAAAGCGTACCGGGTGTGACA
GTCACTGGAGGGGGCGATACTACCGACATCAGCATTCGTGGTATGGGTTCAAACTATACCCTTATCTTGGTGGATGGTAA
GCGCCAAACCTCACGTCAGACCCGTCCAAACAGCGACGGCCCGGGCATTGAGCAAGGTTGGTTGCCGCCACTGCAAGCGA
TTGAGCGCATTGAAGTGATCCGCGGCCCGATGTCTACGCTGTACGGCTCGGATGCGATTGGCGGTGTGATCAACATCATC
ACTCGTAAAGATCAGCAGCAGTGGTCAGGCAATGTGCAGCTATCGACCGTGGTGCAAGAAAATCGCGCCTCAGGCGATGA
ACAAAGCGCTAATTTCTTCGTAACGGGACCTTTAAGTGATGCTCTATCGCTGCAAGTCTACGGACAAACCACGCAACGTG
ATGAAGACGAAATTGAACATGGTTACGGCGATAAATCACTGCGCAGCTTAACCTCAAAGCTCAACTACCAGCTCAATCCA
GATCATCAACTTCAACTGGAAGCCGGTGTATCAGCCCAAGATCGCGAAAATAACGTGGGCAAGTCGGCGCAATCCAGCGG
ATGCCGAGGTACATGCAGCAATACCGATAACCAGTACCGTCGCAACCATGTTGCCGTCTCTCACCAAGGGGATTGGCAGG
ATGTTGGGCAGTCTGATACCTATCTGCAATATGAAGAGAACACCAATAAATCTCGTGAGATGAGCATTGATAATACTGTG
TTCAAATCCACGTTAGTGGCTCCTATTGGTGAGCATATGTTGAGCTTTGGTGTGGAAGGTAAACACGAAAGTTTAGAGGA
TAAAACCTCCAACAAAATTTCGTCTCGCACGCATATCTCGAACACTCAATGGGCGGGATTCATTGAAGATGAATGGGCGC
TTGCAGAGCAATTCCGCCTGACCTTTGGTGGCCGTCTGGATCATGATAAAAACTACGGCAGCCACTTCAGCCCACGTGTG
TATGGCGTATGGAATCTCGATCCTCTATGGACAGTAAAAGGTGGTGTTTCTACTGGCTTCCGTGCACCGCAATTACGTGA
AGTGACGCCGGATTGGGGGCAAGTTAGTGGCGGCGGTAATATTTACGGCAACCCGGATCTCAAGCCTGAAACTTCGATTA
ACAAAGAACTGAGTTTGATGTATAGCACAGGCTCAGGTCTGGCGGCATCGTTGACCGCTTTCCATAATGATTTTAAAGAT
AAAATCACCCGCGTCGCTTGCCCAGCGAATATTTGTACTGCCGGCCCCAACCAATGGGGTGCAGCTCCTACTTATCGTGT
GAATATTGATGAAGCGGAAACCTATGGTGCAGAAGCTACGTTAAGTCTGCCGATCACCGAAAGCGTTGAGTTATCGTCTA
GCTACACGTACACCCATTCGGAGCAAAAATCAGGGAATTTTGCTGGCCGTCCGCTACTGCAGTTACCTAAACATCTGTTC
AATGCCAACTTGAGCTGGCAAACCACAGATCGCCTCAATAGTTGGGCTAACCTCAACTATCGTGGTAAGGAGATGCAGCC
GGAAGGTGGGGCGTCGAACGATGATTTCATCGCGCCAAGCTACACCTTTATCGATACTGGCGTGACTTACGCACTCACCG
ATACCGCAACGATTAAAGCTGCGGTGTACAACCTGTTTGATCAAGAGGTGAATTACGCGGAGTATGGCTATGTAGAAGAT
GGCCGCCGCTACTGGTTGGGCTTAGACATCGCCTTCTAA

Upstream 100 bases:

>100_bases
TTGGACCGAACTATTCCATGTGTCGATCTATCTCCAGTACAGAATATATGAATAATCCGCTTCTGAAATTAAGAATAATT
ATCATTTAAAGGAGTGGTAA

Downstream 100 bases:

>100_bases
TTGCTAGAGGTTTAGAGGATTGGCGGCAGCGCCAATCCTCTGTGTGTTTCGCGATCGGCGGTGGAATCATTTATTGCACA
GGATCGCCGTGCCAAAGCTT

Product: enterobactin receptor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISREDLESRYYRDVTDALKSVPGVT
VTGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDGPGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINII
TRKDQQQWSGNVQLSTVVQENRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNP
DHQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQDVGQSDTYLQYEENTNKSREMSIDNTV
FKSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHISNTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRV
YGVWNLDPLWTVKGGVSTGFRAPQLREVTPDWGQVSGGGNIYGNPDLKPETSINKELSLMYSTGSGLAASLTAFHNDFKD
KITRVACPANICTAGPNQWGAAPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHSEQKSGNFAGRPLLQLPKHLF
NANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPSYTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVED
GRRYWLGLDIAF

Sequences:

>Translated_652_residues
MSRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISREDLESRYYRDVTDALKSVPGVT
VTGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDGPGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINII
TRKDQQQWSGNVQLSTVVQENRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNP
DHQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQDVGQSDTYLQYEENTNKSREMSIDNTV
FKSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHISNTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRV
YGVWNLDPLWTVKGGVSTGFRAPQLREVTPDWGQVSGGGNIYGNPDLKPETSINKELSLMYSTGSGLAASLTAFHNDFKD
KITRVACPANICTAGPNQWGAAPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHSEQKSGNFAGRPLLQLPKHLF
NANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPSYTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVED
GRRYWLGLDIAF
>Mature_651_residues
SRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISREDLESRYYRDVTDALKSVPGVTV
TGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDGPGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINIIT
RKDQQQWSGNVQLSTVVQENRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNPD
HQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQDVGQSDTYLQYEENTNKSREMSIDNTVF
KSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHISNTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRVY
GVWNLDPLWTVKGGVSTGFRAPQLREVTPDWGQVSGGGNIYGNPDLKPETSINKELSLMYSTGSGLAASLTAFHNDFKDK
ITRVACPANICTAGPNQWGAAPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHSEQKSGNFAGRPLLQLPKHLFN
ANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPSYTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVEDG
RRYWLGLDIAF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=703, Percent_Identity=36.1308677098151, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1786798, Length=759, Percent_Identity=28.3267457180501, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1790405, Length=675, Percent_Identity=24.4444444444444, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1787723, Length=160, Percent_Identity=33.75, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 71670; Mature: 71538

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00430 TONB_DEPENDENT_REC_1 ; PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISRED
CCCCCCCCEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEECHHHHHHHCCCCEEEEEEHHH
LESRYYRDVTDALKSVPGVTVTGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDG
HHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEECCCCEEEEEEECCCHHCCCCCCCCCC
PGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINIITRKDQQQWSGNVQLSTVVQE
CCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHEEEEECCCHHHHCCCEEEEEEEHH
NRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNP
HCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHCCEEECC
DHQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQDVGQSDT
CCEEEEECCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHCEEEEECCCCHHHCCCCCC
YLQYEENTNKSREMSIDNTVFKSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHIS
EEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC
NTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRVYGVWNLDPLWTVKGGVSTGF
CCCCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCC
RAPQLREVTPDWGQVSGGGNIYGNPDLKPETSINKELSLMYSTGSGLAASLTAFHNDFKD
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
KITRVACPANICTAGPNQWGAAPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHS
HHHEEECCCHHHCCCCCCCCCCCEEEEECCHHHHCCCCEEEEECCCCCEECCCCEEEECC
EQKSGNFAGRPLLQLPKHLFNANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPS
CCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCC
YTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVEDGRRYWLGLDIAF
EEEEECCEEEEEECCHHHHHHHHHHHHHCCCHHHCCEEECCCEEEEEEEEEC
>Mature Secondary Structure 
SRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISRED
CCCCCCCEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEECHHHHHHHCCCCEEEEEEHHH
LESRYYRDVTDALKSVPGVTVTGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDG
HHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEECCCCEEEEEEECCCHHCCCCCCCCCC
PGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINIITRKDQQQWSGNVQLSTVVQE
CCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHEEEEECCCHHHHCCCEEEEEEEHH
NRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNP
HCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHCCEEECC
DHQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQDVGQSDT
CCEEEEECCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHCEEEEECCCCHHHCCCCCC
YLQYEENTNKSREMSIDNTVFKSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHIS
EEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC
NTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRVYGVWNLDPLWTVKGGVSTGF
CCCCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCC
RAPQLREVTPDWGQVSGGGNIYGNPDLKPETSINKELSLMYSTGSGLAASLTAFHNDFKD
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
KITRVACPANICTAGPNQWGAAPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHS
HHHEEECCCHHHCCCCCCCCCCCEEEEECCHHHHCCCCEEEEECCCCCEECCCCEEEECC
EQKSGNFAGRPLLQLPKHLFNANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPS
CCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCC
YTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVEDGRRYWLGLDIAF
EEEEECCEEEEEECCHHHHHHHHHHHHHCCCHHHCCEEECCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861 [H]