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The map label for this gene is hemY [H]

Identifier: 227080353

GI number: 227080353

Start: 111522

End: 112718

Strand: Reverse

Name: hemY [H]

Synonym: VCM66_0117

Alternate gene names: 227080353

Gene position: 112718-111522 (Counterclockwise)

Preceding gene: 227080354

Following gene: 227080347

Centisome position: 3.9

GC content: 50.79

Gene sequence:

>1197_bases
ATGATTCGTCTCATATTCCTCTTTGTTGTCTTAGGACTTGGCCTGTTTGTGGGAACGCAATACGCTGGCCAACAAGGCTA
TGTGCTGATCTCGATCGCCAATCGCACCATTGAAATGAGTGTCACCACTTTAGTGATTTTTATCATTGGAGCATTGGCTG
CCCTGTTCGCTCTAGAGTTTTTGGTGAAAAAAATCCTCTACACCAGCTTTCACACTTGGAACTGGTTTAGCGTGCGTAAG
CAGCGTCGCTCACGCCGTTATACCAATGAAGGGATCATCAAACTGCTGGAAGGCGATTGGACACAAGCCGAGAAGAAAGT
GACTCGTTGGGCCAATCACCACGATATGCCGCTGCTTTGCTATCTTGTCGCTTCAGAAGCCGCCAATGGTATGGGCGATC
GAGCTAAGCGCGATCGTTACTTAGCGCTGGCCGCTCAGCAAAATAACTCGACTTTGGCGGTGGAGCTGACACGCGCCAAA
CAACAACTGGGTGATGGCGATAACCAAGCTGCCCTTGAAACCTTAACTCAACTGCAGCGCAATCACCCGCACAATACGGT
GGTGCTCAACTTGCTCAAGCAGTGTTATCAAGCCCTTGGCGAGTGGCAACCACTGTTGGCCTTGCTGCCCAAACTGGTCA
AAGCGAAACGTCTGAGCAATGAGGAAGCGCAGCAACTGGAAATCACCGCTCAGCGTGGCATTTTGCAAGACATTGCCAGC
CCAAAAGGCAGTGAAGGCTTGATGCAACATTGGGCTCAGCTGTCACGTAAACTGAAAGCGGAGCCGGAACTTTTGATGTG
CTTTATCACTCAGCTTATTCAACGCAAAGCTGACTATGAGGCCTTCTCAATGATCAAAGAGAGCTTGAAGAAACAAGCGA
CTCCTGAGCTGTACGCGCTACTGCCGGAGCTCAATATCAGCGATCGCCATCCCCTGATTGCCTTGCTGCAAGAAGCGCTG
CGTCGGGATGGCAATAATGCCGAAGCACATAGCGCTTTGGGTCAACTGTATCTGCGTGAGAAACATTGGGCTGATGCGCA
GAAACATCTCGAAAAAGCGCTGTCACTGCGCTCTAGCGTCTCCGACTATGCCTATTTGGCTGATGCACTGGAAAAGCAGA
ATTTCACGCGTGCCGCACACGATGTTTCTCGTAAAGCGCTCTCTTTGCTGGAGTCACCTTCCGCTCAGTCATCCTGA

Upstream 100 bases:

>100_bases
TGGAATACCCCGTTAAATTACAGGCTCAGCAACAGCTCGCCGATGTGATCAACGAACGCTTGCGCCGCAGTGTTTCACCA
CTAACCACGGGGGCTGAGCA

Downstream 100 bases:

>100_bases
ATTAAAATCAGAGCACAAACAACAAGGCCACCGCATGCGGTGGCCTTGTTGTGGAATGCGGTCTTAAATGACTCGCGAGA
ACTGCTGCTGACGCGCCCGC

Product: hemY protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MIRLIFLFVVLGLGLFVGTQYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRK
QRRSRRYTNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDRYLALAAQQNNSTLAVELTRAK
QQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIAS
PKGSEGLMQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEAL
RRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKALSLLESPSAQSS

Sequences:

>Translated_398_residues
MIRLIFLFVVLGLGLFVGTQYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRK
QRRSRRYTNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDRYLALAAQQNNSTLAVELTRAK
QQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIAS
PKGSEGLMQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEAL
RRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKALSLLESPSAQSS
>Mature_398_residues
MIRLIFLFVVLGLGLFVGTQYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRK
QRRSRRYTNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLCYLVASEAANGMGDRAKRDRYLALAAQQNNSTLAVELTRAK
QQLGDGDNQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIAS
PKGSEGLMQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYALLPELNISDRHPLIALLQEAL
RRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSVSDYAYLADALEKQNFTRAAHDVSRKALSLLESPSAQSS

Specific function: Involved in a late step of protoheme IX synthesis [H]

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Escherichia coli, GI1790234, Length=377, Percent_Identity=35.8090185676393, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07219 HemY_N; PF07719 TPR_2 [H]

EC number: NA

Molecular weight: Translated: 44970; Mature: 44970

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLIFLFVVLGLGLFVGTQYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEF
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
LVKKILYTSFHTWNWFSVRKQRRSRRYTNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLC
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHH
YLVASEAANGMGDRAKRDRYLALAAQQNNSTLAVELTRAKQQLGDGDNQAALETLTQLQR
HHHHHHHCCCCCCHHHCCCEEEEEEECCCCEEEEEEHHHHHHHCCCCCHHHHHHHHHHHH
NHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIAS
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
PKGSEGLMQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYAL
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
LPELNISDRHPLIALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSV
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDYAYLADALEKQNFTRAAHDVSRKALSLLESPSAQSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIRLIFLFVVLGLGLFVGTQYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEF
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
LVKKILYTSFHTWNWFSVRKQRRSRRYTNEGIIKLLEGDWTQAEKKVTRWANHHDMPLLC
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHH
YLVASEAANGMGDRAKRDRYLALAAQQNNSTLAVELTRAKQQLGDGDNQAALETLTQLQR
HHHHHHHCCCCCCHHHCCCEEEEEEECCCCEEEEEEHHHHHHHCCCCCHHHHHHHHHHHH
NHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQDIAS
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
PKGSEGLMQHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKKQATPELYAL
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
LPELNISDRHPLIALLQEALRRDGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSSV
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDYAYLADALEKQNFTRAAHDVSRKALSLLESPSAQSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]