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The map label for this gene is trkH-1 [H]

Identifier: 227080279

GI number: 227080279

Start: 39102

End: 40547

Strand: Reverse

Name: trkH-1 [H]

Synonym: VCM66_0042

Alternate gene names: 227080279

Gene position: 40547-39102 (Counterclockwise)

Preceding gene: 227080280

Following gene: 227080278

Centisome position: 1.4

GC content: 51.31

Gene sequence:

>1446_bases
ATGCTCAACTTACGCCCAATTACGTTTATCATCGGGCTAGTGCTGTCTAAGCTAGCCCTATTCATGTACGTGCCGACTCT
AGTGGCATTTTTTACTGGCAGCGGCGGTTTTCTCGATTTCGCGCAAGCCGTCATCATTACCCATCTGGTGGCGTTTCTCT
GCTTAAGTATCGGTCGCACTGAACATTTTCGGCTCAACGTACGTGATATGTTCCTGATCACCAGCTTGGTATGGACGATT
GCCAGCGCATTTGCTGCTCTGCCTTTTGTGTTTATTAACCACATCAGCTTTACCGATGCCTATTTTGAAACCATGTCCGG
CCTTACCACCACAGGCTCCACGGTACTCAGTGGCTTAGATGATATGCCGCCCAGTATTTTGTTGTGGCGCTCCATTTTGC
AATGGTTAGGTGGCGTGGGCTTTATCGTGATGGCGGTAGCGGTGTTGCCGATGCTCAATGTTGGGGGGATGAAGCTGTTC
CAAACCGAATCGTCTGATTGGTCGGATAAAAGCAGCCCGCGCGCGAAAACCGTCGCGAAAAACATTGTGGCGGTGTATCT
GGTTTTGACTGGGCTCTGTTTTTTGAGCTATATCGCCACAGGTATGACGCCGTTTGAAGCGATTAATCACGCCTTTACCA
CGCTTTCCACCGGCGGCTACTCGACCAGTGATAGCTCGATGAACCGCTTCTCACACGGCGCGCACTGGGTTGGCACACTC
TTTATGTTTCTTGGTGGCCTGCCATTTTTACTGTTTGTGCAGGCTCTGCGCAAACAGAGTGCACGAGCCCTACTCAAAGA
TGAGCAGGTACGCGGCTTCTTCTGGCTCTTTATGATCTCCAGTTTGCTGGTCGCAGGTTGGTTGTGGCTCAAAAACGATT
ACGCGATATTGGATGCGCTGCGAGTTTCGATGTTTAACATTGTCTCCGTCGTCACAACCACGGGCTATGGTCTGGATGAT
TTCACCGCGTGGGGCGCGCTCCCCTCAACCATTTTTGCCTTCCTATTGATGGCCGGCGCTTGCTCGGGTTCTACCTCTGG
CGGAATTAAGGTCTTTCGTTTCCAAATCGCGATGGCACTGCTCAAAAAGCAACTGCTGAACCTCATCCACCCTTCTGGCA
TTTTTATCCAGCGCTATAACAAGCGCCCGGTCAATGAAGAGATCATCCGCTCCGTAGTCGCCTTTGGCTTGACGTTTTTC
ATCACTATCGTGGTACTGGCTGGCGCGTTATCGGCAATGGGATTGGATTCGGTGACCAGTATCTCTGGCGCGGTCACTGC
CGTGGCTAACGTGGGTCCAGGTATGGGCAGCATCATTGGCCCAACGGGTAACTTTGCCCCTCTACCGGATGCCGCCAAAT
GGCTCTTGAGCTTTGGAATGTTGATGGGACGTTTAGAAATTCTGACGATTTTGGTGCTCTTTTTCCCTGCATTCTGGCGT
CATTAA

Upstream 100 bases:

>100_bases
AAGACGATCACGTCGTCATGTTCTTGGTCGATAAAAAATATGTGCCCGACGTGGAAACGCTATTCCAGCCGAGCCCATTC
TTCTTGTAAAGGTTGGCGCT

Downstream 100 bases:

>100_bases
AAGGAAACATAATGAAAAAACTCATATTGGTAGCCAGCATAGTGAGCTTATCCACTTGGGCAAGCGAAACCTTACAGCTC
AAGGATGGCCGCTATATTCA

Product: potassium uptake protein TrkH

Products: Proton [Cytoplasm]; K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MLNLRPITFIIGLVLSKLALFMYVPTLVAFFTGSGGFLDFAQAVIITHLVAFLCLSIGRTEHFRLNVRDMFLITSLVWTI
ASAFAALPFVFINHISFTDAYFETMSGLTTTGSTVLSGLDDMPPSILLWRSILQWLGGVGFIVMAVAVLPMLNVGGMKLF
QTESSDWSDKSSPRAKTVAKNIVAVYLVLTGLCFLSYIATGMTPFEAINHAFTTLSTGGYSTSDSSMNRFSHGAHWVGTL
FMFLGGLPFLLFVQALRKQSARALLKDEQVRGFFWLFMISSLLVAGWLWLKNDYAILDALRVSMFNIVSVVTTTGYGLDD
FTAWGALPSTIFAFLLMAGACSGSTSGGIKVFRFQIAMALLKKQLLNLIHPSGIFIQRYNKRPVNEEIIRSVVAFGLTFF
ITIVVLAGALSAMGLDSVTSISGAVTAVANVGPGMGSIIGPTGNFAPLPDAAKWLLSFGMLMGRLEILTILVLFFPAFWR
H

Sequences:

>Translated_481_residues
MLNLRPITFIIGLVLSKLALFMYVPTLVAFFTGSGGFLDFAQAVIITHLVAFLCLSIGRTEHFRLNVRDMFLITSLVWTI
ASAFAALPFVFINHISFTDAYFETMSGLTTTGSTVLSGLDDMPPSILLWRSILQWLGGVGFIVMAVAVLPMLNVGGMKLF
QTESSDWSDKSSPRAKTVAKNIVAVYLVLTGLCFLSYIATGMTPFEAINHAFTTLSTGGYSTSDSSMNRFSHGAHWVGTL
FMFLGGLPFLLFVQALRKQSARALLKDEQVRGFFWLFMISSLLVAGWLWLKNDYAILDALRVSMFNIVSVVTTTGYGLDD
FTAWGALPSTIFAFLLMAGACSGSTSGGIKVFRFQIAMALLKKQLLNLIHPSGIFIQRYNKRPVNEEIIRSVVAFGLTFF
ITIVVLAGALSAMGLDSVTSISGAVTAVANVGPGMGSIIGPTGNFAPLPDAAKWLLSFGMLMGRLEILTILVLFFPAFWR
H
>Mature_481_residues
MLNLRPITFIIGLVLSKLALFMYVPTLVAFFTGSGGFLDFAQAVIITHLVAFLCLSIGRTEHFRLNVRDMFLITSLVWTI
ASAFAALPFVFINHISFTDAYFETMSGLTTTGSTVLSGLDDMPPSILLWRSILQWLGGVGFIVMAVAVLPMLNVGGMKLF
QTESSDWSDKSSPRAKTVAKNIVAVYLVLTGLCFLSYIATGMTPFEAINHAFTTLSTGGYSTSDSSMNRFSHGAHWVGTL
FMFLGGLPFLLFVQALRKQSARALLKDEQVRGFFWLFMISSLLVAGWLWLKNDYAILDALRVSMFNIVSVVTTTGYGLDD
FTAWGALPSTIFAFLLMAGACSGSTSGGIKVFRFQIAMALLKKQLLNLIHPSGIFIQRYNKRPVNEEIIRSVVAFGLTFF
ITIVVLAGALSAMGLDSVTSISGAVTAVANVGPGMGSIIGPTGNFAPLPDAAKWLLSFGMLMGRLEILTILVLFFPAFWR
H

Specific function: Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity [H]

COG id: COG0168

COG function: function code P; Trk-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trkH potassium transport family [H]

Homologues:

Organism=Escherichia coli, GI48994987, Length=490, Percent_Identity=35.1020408163265, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1787626, Length=488, Percent_Identity=31.3524590163934, Blast_Score=219, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003445
- InterPro:   IPR004772 [H]

Pfam domain/function: PF02386 TrkH [H]

EC number: NA

Molecular weight: Translated: 52394; Mature: 52394

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Periplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Periplasm] = Proton [Cytoplasm] + K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]