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The map label for this gene is lon2 [H]

Identifier: 226951073

GI number: 226951073

Start: 4132525

End: 4134444

Strand: Reverse

Name: lon2 [H]

Synonym: CLM_4126

Alternate gene names: 226951073

Gene position: 4134444-4132525 (Counterclockwise)

Preceding gene: 226951074

Following gene: 226951072

Centisome position: 99.5

GC content: 29.01

Gene sequence:

>1920_bases
GTGAATTCTCATAAATTAGATGAATTACAAGAGGATATAATAAATGAAATAGAACAGGATATTTCAAAGGACATGTCTAT
TGAGTTACAGACAGAGGTTTTATTTGAAATAGTAAAAAAAATAATAAAAGATTCTAATATAAGGGCTAGAGTTGTAAAGT
ATAAATTAGAAAAATATATAAATAGTAACAACCCATATGAAAGGCTATATGCATTAAATAAAATAATAAGTGATGGTAAG
GGGATACAAACAGTACCTACAGATAAGAACGTCATAGAAGTATTAACAGAAACAAATAGATTAATTGTGGAAGTTTTAGC
TAAAAGATATGTTGAAAATAATATAGAAAAAGAAGTAGAACAAGTTTTAATGGAAAAACAAGATAAATATATAGAAGAAG
TAAAACTTAATATTCTAAAGAAACAAAAGGGACCAGAAAATGCTAAAACCTTAAAAAAATATGCACATATAGAGGTTCTT
GAGTCTAAAAAATTAACTAATAATATTCAACATTTATTAAGACCTGCTTCTTTTTCAGAAATTATAGGACAGGAAAGACC
TATAAAATCTCTTTTATCTAAAATAGCATCTCCGTACCCACAACATATTATACTATATGGGCCACCAGGGGTAGGAAAAA
CATCTGCAGCTAGATTAGCTTTAGAAGAAGTAAAAAAGTTAAAATATACACCTTTTTATAAAGATTCTAAATTTGTAGAG
GTAGATGGAACTACTTTAAGATGGGATCCAAGAGAGATTACTAATCCTCTTTTAGGATCAGTACATGATCCTATATATCA
AGGTTCTAAAAGAGATTTGGCAGAAACTGGTATACCAGAGCCTAAACTAGGATTAGTTACAGAAGCTCATGGAGGCGTAC
TGTTTATAGATGAAATAGGTGAGTTAGATGATATGCTTCAAAATAAACTTTTAAAGGTTTTGGAAGACAAAAGGGTAGAA
TTTTCATCTTCTTATTATGATCCAGATGATGAAAATACTCCTAAGTATATAAAACACTTATTTGAAAATGGAGCACCAGC
TGATTTTGTACTTATAGGGGCTACTACTAGGGAACCTTCAGAAATAAATCCAGCACTAAGATCTAGATGTGCGGAAGTAT
TTTTTGAGCCATTATCCTCTAAAGATATTGAAAAAATAGTAATAAATGCCGCAGATAAATTAAATATAATATTAGAGGAT
GGGGTAGCTCAAACTATAAGTAGATATACCATAGAGGGAAGAAAAGCAGTTAATATATTATCAGATGTCTATGGATATGC
TTTATATAGAAATAAAGAATATAAAGAAGGAACAAAACTTAATATAACTATGGATGACTTAGAACAAGTTATATCTATAA
GTAGATTAATTCCATACGATAGAATAGAAAATAAAGAAAAATTAGAAATAGGACATGTATATGGATTAGGTGTAAGTGGA
TATATAGGATCTACTATAGAAATAGAAACTACTGTATTTAATGCTAAGGATAAAGGTAAAGGCTTTATTAGATTTAATGA
TACAGCAGGAAGTATGGCGAAGGATTCAGTATTTAATGCCGCTTCTGTTATAAGAAAAATAACAAAAGAAGATATAAAGG
ATTATGATGTACATGTTAATGCTATAGGTGGTGGGAAAATAGATGGACCATCTGCAGGAGCAGCTATAACAATATGTATT
ATTAGCGCTTTATTAAACAAGCCTATTAAACAGGATATAGCTATAACAGGAGAAATATCTCTTAAAGGAAAGATAAAGCC
TGTTGGAGGCATATTTGAAAAAATATATGGTGCAAGAAGAAAAGGCATAAAAAAGGTAATAATACCTAAAGACAATATGA
AAGATGCTCCTTCAGATATAAAAGATATAGAAATAATATGTATAAATACTATAGAAGAGCTTATAAATATAGTATTTTAA

Upstream 100 bases:

>100_bases
ACTATAAGACAAACAGGAGTTTATGAGGCAGAAATAAAAATTTACCCAGAAGTTTCAACTAAAGTTAAAGTTTCTGTTTT
AGAAGAATAGGAGGAAAATT

Downstream 100 bases:

>100_bases
ATTGAGGAGTACTTAAGGAGAGATGTTTATATGGATGCACCCATAAAAAGTATGCCGCAGAGTATAGATGCAGAGCAAAA
TGTATTAGGGGCAATGATTA

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYINSNNPYERLYALNKIISDGK
GIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEKEVEQVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYAHIEVL
ESKKLTNNIQHLLRPASFSEIIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYKDSKFVE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIGELDDMLQNKLLKVLEDKRVE
FSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPSEINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILED
GVAQTISRYTIEGRKAVNILSDVYGYALYRNKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEKLEIGHVYGLGVSG
YIGSTIEIETTVFNAKDKGKGFIRFNDTAGSMAKDSVFNAASVIRKITKEDIKDYDVHVNAIGGGKIDGPSAGAAITICI
ISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARRKGIKKVIIPKDNMKDAPSDIKDIEIICINTIEELINIVF

Sequences:

>Translated_639_residues
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYINSNNPYERLYALNKIISDGK
GIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEKEVEQVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYAHIEVL
ESKKLTNNIQHLLRPASFSEIIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYKDSKFVE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIGELDDMLQNKLLKVLEDKRVE
FSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPSEINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILED
GVAQTISRYTIEGRKAVNILSDVYGYALYRNKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEKLEIGHVYGLGVSG
YIGSTIEIETTVFNAKDKGKGFIRFNDTAGSMAKDSVFNAASVIRKITKEDIKDYDVHVNAIGGGKIDGPSAGAAITICI
ISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARRKGIKKVIIPKDNMKDAPSDIKDIEIICINTIEELINIVF
>Mature_639_residues
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYINSNNPYERLYALNKIISDGK
GIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEKEVEQVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYAHIEVL
ESKKLTNNIQHLLRPASFSEIIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYKDSKFVE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIGELDDMLQNKLLKVLEDKRVE
FSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPSEINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILED
GVAQTISRYTIEGRKAVNILSDVYGYALYRNKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEKLEIGHVYGLGVSG
YIGSTIEIETTVFNAKDKGKGFIRFNDTAGSMAKDSVFNAASVIRKITKEDIKDYDVHVNAIGGGKIDGPSAGAAITICI
ISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARRKGIKKVIIPKDNMKDAPSDIKDIEIICINTIEELINIVF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=515, Percent_Identity=26.0194174757282, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI21396489, Length=185, Percent_Identity=31.8918918918919, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI1786643, Length=482, Percent_Identity=26.9709543568465, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790850, Length=101, Percent_Identity=33.6633663366337, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789828, Length=115, Percent_Identity=40.8695652173913, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17556486, Length=483, Percent_Identity=24.4306418219462, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17505831, Length=158, Percent_Identity=38.6075949367089, Blast_Score=89, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319449, Length=101, Percent_Identity=36.6336633663366, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221513036, Length=482, Percent_Identity=26.9709543568465, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24666867, Length=484, Percent_Identity=27.2727272727273, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 71821; Mature: 71821

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYI
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NSNNPYERLYALNKIISDGKGIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEKEVE
CCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYAHIEVLESKKLTNNIQHLLRPASFSE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYKDSKFVE
HHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIG
ECCCEEEECHHHHCCHHHHHHCCHHHCCCCCCHHHCCCCCCCCCEEEECCCCEEEEHHHH
ELDDMLQNKLLKVLEDKRVEFSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPS
HHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCC
EINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILEDGVAQTISRYTIEGRKAVNIL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHH
SDVYGYALYRNKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEKLEIGHVYGLGVSG
HHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEECCCCC
YIGSTIEIETTVFNAKDKGKGFIRFNDTAGSMAKDSVFNAASVIRKITKEDIKDYDVHVN
CCCCEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AIGGGKIDGPSAGAAITICIISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARR
EECCCCCCCCCCCHHHHHHHHHHHHCCCCHHCEEEEEEEEECCCCCHHHHHHHHHHHHHH
KGIKKVIIPKDNMKDAPSDIKDIEIICINTIEELINIVF
CCCEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MNSHKLDELQEDIINEIEQDISKDMSIELQTEVLFEIVKKIIKDSNIRARVVKYKLEKYI
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NSNNPYERLYALNKIISDGKGIQTVPTDKNVIEVLTETNRLIVEVLAKRYVENNIEKEVE
CCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVLMEKQDKYIEEVKLNILKKQKGPENAKTLKKYAHIEVLESKKLTNNIQHLLRPASFSE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IIGQERPIKSLLSKIASPYPQHIILYGPPGVGKTSAARLALEEVKKLKYTPFYKDSKFVE
HHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEE
VDGTTLRWDPREITNPLLGSVHDPIYQGSKRDLAETGIPEPKLGLVTEAHGGVLFIDEIG
ECCCEEEECHHHHCCHHHHHHCCHHHCCCCCCHHHCCCCCCCCCEEEECCCCEEEEHHHH
ELDDMLQNKLLKVLEDKRVEFSSSYYDPDDENTPKYIKHLFENGAPADFVLIGATTREPS
HHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCC
EINPALRSRCAEVFFEPLSSKDIEKIVINAADKLNIILEDGVAQTISRYTIEGRKAVNIL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHH
SDVYGYALYRNKEYKEGTKLNITMDDLEQVISISRLIPYDRIENKEKLEIGHVYGLGVSG
HHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEECCCCC
YIGSTIEIETTVFNAKDKGKGFIRFNDTAGSMAKDSVFNAASVIRKITKEDIKDYDVHVN
CCCCEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AIGGGKIDGPSAGAAITICIISALLNKPIKQDIAITGEISLKGKIKPVGGIFEKIYGARR
EECCCCCCCCCCCHHHHHHHHHHHHCCCCHHCEEEEEEEEECCCCCHHHHHHHHHHHHHH
KGIKKVIIPKDNMKDAPSDIKDIEIICINTIEELINIVF
CCCEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]