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The map label for this gene is fhs [H]

Identifier: 226950980

GI number: 226950980

Start: 4033592

End: 4035265

Strand: Reverse

Name: fhs [H]

Synonym: CLM_4009

Alternate gene names: 226950980

Gene position: 4035265-4033592 (Counterclockwise)

Preceding gene: 226950981

Following gene: 226950979

Centisome position: 97.11

GC content: 31.12

Gene sequence:

>1674_bases
ATGTTTAAATCCGATATAGAAATAGCACAAGAATCTAAAATGAAAAATATAAAAAATATAGCTGAGAAGATAGGGTTAAC
AGAAGAAGATATAGATTTATATGGGAAATATAAATGTAAAATTTCATTAGATGTTTTAAAGAGCAATAAAGATAAAAAAG
ATGGAAAACTAATTTTAGTTACAGCTATAAATCCTACTCCAGCAGGAGAAGGAAAATCCACAGTTACAGTAGGTTTAGGG
CAAGCCTTATGGAAGAAAAATAAAAAAGCGGTTATAGCATTAAGAGAACCTTCTTTGGGACCTGTATTTGGTATAAAAGG
AGGTGCAGCTGGAGGAGGATACTCTCAAGTTGTACCTATGGAAGATATAAATCTTCATTTTACAGGTGATATGCATGCTA
TTACTTCAGCTAATAATTTATTAGCTGCTGCTATAGATAACCATATTCATCAAGGAAATATTTTGAAGATTGATCAAAGA
AGAATTCTCTTTAAAAGAGTTATGGATATTAATGATAGAGCTTTAAGAAATGTAATTGTAGCCTTAGGTGGAAAAATAAA
TGGATTTCCAAGAGAAGATGGATTTATGATAACTGTAGCTTCAGAGATTATGGCTATATTATGTTTAGCAGAAGATCTTA
TGAATCTTAAGAATAAAATGGGAGAAATATTAGTAGCTTATAGTACAGAGGGAAAACCTATATACTGCAAAGATTTAGAG
GTTCAGGGAGCTATGGCATTATTAATGAAAGATGCTATAAAACCTAATCTAGTTCAAACTTTAGAAAATACTCCGGCTAT
TATACATGGTGGACCTTTCGCTAATATAGCTCATGGATGTAATAGTATATTGGGAACAAAGATGGCCTTAAAATTAGGAG
ATTATGTAATAACAGAGGCAGGCTTTGGAGCAGATCTAGGAGCAGAAAAGTTTTTTGATATTAAATGTAGAAAAGCTAAT
TTAAAACCAAATTGTGTAGTTATAGTAGCTACAGTAAGAGCTTTAAAATATAATGGTGGGATTCCTAAGGAAAATCTAAA
GGAACAAAATATGGAAGCCCTATCAAAGGGTATAAAAAATCTAGGGAAACATATAGAGAATGTTAATAAGTTTGGTGTAC
CAGCAGTAGTTGCTATAAATAAATTTATATCAGATACAGAAGAAGAAATAGAATTTATAAAAAAATATTGTAAAGAATTA
GGCGCAGAAGTGTCTATAGCAGAGGTATGGGAAAAAGGTGGAAATGGTGGCTTAGAATTAGCTGATAAAGTTTTAGATAC
CATAGAAAATAAAGAAAGTAAATTTAATCCTATATACGAGGAAACTCTTAATATAAAACAAAAAATAGAAACAATTGCCC
AGGAAATATATGGAGCAGAAGGGGTAGATTATTCTAAAGAGGCAGAAAAGCAAATATCTGAAATAGAAAAATTAGATTTA
GATAAAAAGCCTGTATGTATGGCAAAAACTCAGTATTCTTTATCAGATGATGCTAGACTATTAGGAAGACCATGTGGATT
TAGAATTAATGTCAAAGAAGTTAGAATATCCAATGGGGCTGGATTTATAGTTGTGTTAACAGGAAATGTTATGACTATGC
CAGGTTTACCTAAGAAACCTGCAGCTAACAATATGAATGTATTATCAGATGGCAATATAGTTGGACTATTCTAA

Upstream 100 bases:

>100_bases
AGAGTAGAATTAAAAAATTATTAAACAACGAATAAATAATTATTCAATTACACAAAAATAATTAATAGGGTCCGTATTAT
AACTAAGGGGGAATATATAA

Downstream 100 bases:

>100_bases
CATTAATATAACAGAAGTATTAACTTGACAAAATAATTGGAACTGATAAAATAAAATTATTAAATTGACATTAAATCAAG
CATAAAGGGCAGCGGCAAGG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKSNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDINDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMNLKNKMGEILVAYSTEGKPIYCKDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDARLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMNVLSDGNIVGLF

Sequences:

>Translated_557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKSNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDINDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMNLKNKMGEILVAYSTEGKPIYCKDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDARLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMNVLSDGNIVGLF
>Mature_557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKSNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDINDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMNLKNKMGEILVAYSTEGKPIYCKDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDARLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMNVLSDGNIVGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=620, Percent_Identity=43.7096774193548, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=44.5880452342488, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=43.8906752411576, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=43.8906752411576, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=42.654028436019, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=42.4920127795527, Blast_Score=449, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=42.81098546042, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=42.81098546042, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=42.6494345718901, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=42.6494345718901, Blast_Score=458, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60708; Mature: 60708

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00721 FTHFS_1 ; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKSNKDKKDGKLILV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCEEEE
TAINPTPAGEGKSTVTVGLGQALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPM
EEECCCCCCCCCCEEEEECCHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEECCC
EDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQRRILFKRVMDINDRALRNVIV
CCCEEEECCCCCEECCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHH
ALGGKINGFPREDGFMITVASEIMAILCLAEDLMNLKNKMGEILVAYSTEGKPIYCKDLE
HHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCC
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEA
HHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
GFGADLGAEKFFDIKCRKANLKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKN
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKELGAEVSIAEVWEKGGNGGLEL
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHH
ADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
DKKPVCMAKTQYSLSDDARLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKP
CCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEEEEEECCCCEEEEEECCEEECCCCCCCC
AANNMNVLSDGNIVGLF
CCCCCEEECCCCEEEEC
>Mature Secondary Structure
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKSNKDKKDGKLILV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCEEEE
TAINPTPAGEGKSTVTVGLGQALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPM
EEECCCCCCCCCCEEEEECCHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEECCC
EDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQRRILFKRVMDINDRALRNVIV
CCCEEEECCCCCEECCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHH
ALGGKINGFPREDGFMITVASEIMAILCLAEDLMNLKNKMGEILVAYSTEGKPIYCKDLE
HHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCC
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEA
HHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
GFGADLGAEKFFDIKCRKANLKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKN
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKELGAEVSIAEVWEKGGNGGLEL
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHH
ADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
DKKPVCMAKTQYSLSDDARLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKP
CCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEEEEEECCCCEEEEEECCEEECCCCCCCC
AANNMNVLSDGNIVGLF
CCCCCEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA