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The map label for this gene is uvrB [H]

Identifier: 226950837

GI number: 226950837

Start: 3893762

End: 3895750

Strand: Reverse

Name: uvrB [H]

Synonym: CLM_3849

Alternate gene names: 226950837

Gene position: 3895750-3893762 (Counterclockwise)

Preceding gene: 226950838

Following gene: 226950836

Centisome position: 93.75

GC content: 29.46

Gene sequence:

>1989_bases
ATGAACCAATTTAAGGTAATTTCAAAATTTAATCCTACAGGAGATCAACCTAAAGCTATAAAATCTATTGCTAAAGGCAT
AGAAAAAAGAGAAAAATTTCAAACTTTAATAGGCGTGACCGGATCAGGTAAAACTTTTACTATGGCAAATATTATAGAAA
AAGTTCAAAAGCCTACCTTAGTTTTAGCTCATAATAAAACACTGGCAGCACAATTATGCTCAGAATTTAGAGAGTTTTTT
CCTAATAATGCAGTAGAATATTTTGTATCTTATTATGATTATTATCAACCAGAAGCATACGTAGCTCAAAGTGATACATA
TATAGAAAAAGATGCATCTATAAATGATGAAATAGATAAATTAAGGCACTCAGCCACATCAGCTTTATTTGAAAGAAAAG
ATGTAATAATTGTTGCTTCTGTATCTTGTATATATGGACTTGGTAATCCAGAAGAGTATAAAAAGTTAACTATATCGTTA
AGAGAAGGTATGGAGAAGGATAGAGATGAAATAATTAAAAAATTAGTAGAAATACAATATGAAAGAAATGACATAGATTT
TTCTAGAGGTACTTTTAGAGTAAAAGGTGATGTTTTAGATATTTTTCCTGCTTCATCTAGTAGCAAAGCAGTAAGAGTAG
AATTTTTTGGTGACGAAATAGATAGAATAAAAGAATTTGATGTTTTAACAGGAGAAACTATAACTAAGTTAAAACATATA
TCTATATTCCCAGCATCTCACTTTGCAACTTCAAAGGATAGACTGGAAGTTGCTATAAAAGATATAGAAGAAGAGCTAGA
AGAAAGAGTAAAAGAATTAGTATCTCAGGATAAAATATTAGAGGCTCAAAGATTAAAGCAGAGAACTAATTTTGATATAG
AAATGATGAGAGAAGTTGGATACTGTACAGGCATTGAAAATTATTCAAGAGTGTTAGATGGAAGAGCAAAAGGAACACCA
CCTCAGACCCTTTTAGATTATTTTCCACAGGATTTTCTTCTTTTTATAGATGAAAGTCATGTAACTTTGCCACAGGTAAA
AGCTATGCAGGCAGGAGATAAATCTAGAAAAGATTCTTTGGTGGAATATGGATTCAGGTTGCCTTGTGCCTATGATAATA
GGCCTCTTACCTTTAAGGAATTTGAAAATAAATTAAATCAAGTAGTTTTTGTAAGTGCTACACCAGCAAAATATGAATTA
GAATATTCAACTAACACAGCAGAGCAAGTAATAAGGCCTACAGGACTTTTAGATCCTGAAATAATTGTAAAACCAGTAAA
GGGACAGATAGACGACTTATATACTAGCATACAAGAAACAATTAAAAGAGGATTTAGAATTTTAGTAACTACATTAACAA
AAAAAATGGCAGAAGACTTGACTGATTATTTAAAAGAAATGGGAGTAAAAACTAGATATTTACATTCAGATATAGATACT
ATAGAAAGAATGAAAATAATACATGATCTTAGAAAAGGAGAATTTCATGTTTTAGTAGGAATAAACTTGCTAAGAGAAGG
ATTGGATATACCAGAAGTAGCTTTAGTTACAATATTAGATGCAGATAAAGAGGGATTTTTAAGATCAGAAACATCTCTTA
TACAGACTGTCGGAAGAGCAGCAAGAAACTCTGAAAGTAAGGTAATTATGTATGGGGATGTTATAACCAAATCCATGGAA
AAGACTATAAAAGAAACTAATAGAAGAAGAAAAATACAAATGGAATATAATGAAGAATATGGAATTGTTCCTAAAACTAT
AATAAAAGATATAAGAGAAGTAATTCAAATAAGTGATATAGCAGAGGAAAGAAAAGAATATGACAATTTAAATGAAGCAT
TAAAATCTTATAATAATGATATAGATAAATTAATAGAGAAATATGAAGAAGAAATGAAAGAGGCAGCACAAAATTTACAG
TTTGAAAAAGCGGCTCATTTGAGAGATGTAATATACAAATTAAAAAAAGATAAAGAAACAGAACTTTAA

Upstream 100 bases:

>100_bases
CCTAAAAATGTACCTAAAAATACATCCGTAATAAAAGTTAAAAGTGAAAAATTTCAAGACATATTAGAAAAAATTAAAAA
CAAAGATAAGGATGAATAAG

Downstream 100 bases:

>100_bases
GGAGTGTAATAACAAATAATGAAGGATAAAATTATTATTAAAGGCGCTAAGGTTAATAATTTAAAAAATATAAATCTTCA
GTTGCCGAGAGATAAGTATA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFREFF
PNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISL
REGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAKGTP
PQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYEL
EYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITKSME
KTIKETNRRRKIQMEYNEEYGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQ
FEKAAHLRDVIYKLKKDKETEL

Sequences:

>Translated_662_residues
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFREFF
PNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISL
REGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAKGTP
PQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYEL
EYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITKSME
KTIKETNRRRKIQMEYNEEYGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQ
FEKAAHLRDVIYKLKKDKETEL
>Mature_662_residues
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFREFF
PNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISL
REGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAKGTP
PQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYEL
EYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITKSME
KTIKETNRRRKIQMEYNEEYGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQ
FEKAAHLRDVIYKLKKDKETEL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=56.5610859728507, Blast_Score=756, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=229, Percent_Identity=24.0174672489083, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76244; Mature: 76244

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTL
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHCCCEE
VLAHNKTLAAQLCSEFREFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDK
EEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHHHHH
LRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISLREGMEKDRDEIIKKLVEIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHE
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVG
EEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YCTGIENYSRVLDGRAKGTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSL
HHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHH
VEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYELEYSTNTAEQVIRPTGLLDPE
HHCCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCEEEEEECCCHHHHHHCCCCCCCHH
IIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRA
HHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
ARNSESKVIMYGDVITKSMEKTIKETNRRRKIQMEYNEEYGIVPKTIIKDIREVIQISDI
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQFEKAAHLRDVIYKLKKDKET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
EL
CC
>Mature Secondary Structure
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTL
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHCCCEE
VLAHNKTLAAQLCSEFREFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDK
EEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHHHHH
LRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISLREGMEKDRDEIIKKLVEIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHE
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVG
EEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YCTGIENYSRVLDGRAKGTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSL
HHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHH
VEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYELEYSTNTAEQVIRPTGLLDPE
HHCCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCEEEEEECCCHHHHHHCCCCCCCHH
IIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRA
HHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
ARNSESKVIMYGDVITKSMEKTIKETNRRRKIQMEYNEEYGIVPKTIIKDIREVIQISDI
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQFEKAAHLRDVIYKLKKDKET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
EL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA