| Definition | Clostridium botulinum A2 str. Kyoto chromosome, complete genome. |
|---|---|
| Accession | NC_012563 |
| Length | 4,155,278 |
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The map label for this gene is lysA [H]
Identifier: 226950770
GI number: 226950770
Start: 3814523
End: 3815791
Strand: Reverse
Name: lysA [H]
Synonym: CLM_3780
Alternate gene names: 226950770
Gene position: 3815791-3814523 (Counterclockwise)
Preceding gene: 226950771
Following gene: 226950769
Centisome position: 91.83
GC content: 28.53
Gene sequence:
>1269_bases ATGAATATAAAGAACAATAATTTATATATAGGTGAAATAAATACGTTAGACTTGGCTAAGAAATTTAAAACACCTTTATA TGTAATGGATGAAACTCTTATAAGAGATAATTGTAGAAGATATATAACTTCATTTGATAAAGAAAAAAACAAAGTAGCTT ATGCAGGAAAAGCTTTTCTTACTAAGGCTATGTGCAATTTAATAAAAGAAGAAGGGCTTTCTTTAGATGTAGTATCAGGA GGAGAGATATTTACTGCTTATAGAAGCGGATTTCCTATGGACAAAGTGTATTTTCATGGTAATAATAAAACTATAGAAGA AATAGAAATGGCTATAAATTTAGGGGTCGGAACCTTTGTAGCAGATAATTTTCAGGAATTAGATAAGATAAACAATATCT GTAAAAATAAAAATATAAAGCAAAGAGTAATTTTAAGAATAATTCCAGGTATTGAGGCGCATACCCATGAATATATTAGA ACTGGCCAAATAGATTCCAAATTTGGATTTACATTAATAGATGATGGTGCTATCAAAGCAGTAAAAAAAGCCTCTGAATT AGAAAACATACAATTTGTTGGGTTCCATTGTCATATAGGTTCTCAGATATTTGAAACAAAACCTTATGAAGAAGAAATAG AAATAATGCTTAGGCTAATAAAAAGAACTAATGAAGAACTAAATATAGATATAGAGGAACTAGATTTAGGTGGGGGTTTT GGAATATATTATAAAGAGGGGGATGAACCTAAAAAAATAGAAGAGTTTTGCAAAATTATATTAGATAAAACGAAAAGTTA TTCAAAAGAGATAGGAGTTAAAGAACCTATTCTAGTAATAGAGCCAGGTAGATCTATAGTCGGTAATTCAGGAGTTACAT TGTATTCTGTAGGTTCTATTAAAGAAATCCCTAATATAGCTAAATATATAGCTGTAAATGGAGGGATGACTGATAATATA AGGCCTGCATTATATAAATCAGAATATGAATGTGTAGTATGTAACAAGGCTTTAGATAATCTATTAGAAGAAGTAAAAGT AGTAGGGAAATGTTGTGAATCAGGGGACATACTTATAGATAATGTAAAATTACCAATAGTAGAAACTGATGATTTGCTCG CAATATTAAATACAGGAGCTTATGGATATTCTATGGCAAGTAATTATAATAAAGCATTATTACCATCTGTAGTCTTTGTT AATAATGATAAAACAAAATTAGTATGTAGAAGACAAAGCTATGAAAATTTAATACAAAATGAAGTATAA
Upstream 100 bases:
>100_bases TTGTGCAATAAATGTAAGGGATAAAATAAATGCTATAAATTTAGTAGTAAAAGAATTTAATTTATAAATAGGATGTGGGA GTATGAAACTTTTTGGAAGT
Downstream 100 bases:
>100_bases AATATTTATCAAAAACAATATAGTTACTGAGATAAATGTTTTTTAGTAATGATAATTAAAAGATCTTATTGAGTTGAATT TGAACCAACTCAATAAGATT
Product: diaminopimelate decarboxilase
Products: NA
Alternate protein names: DAP decarboxylase [H]
Number of amino acids: Translated: 422; Mature: 422
Protein sequence:
>422_residues MNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYITSFDKEKNKVAYAGKAFLTKAMCNLIKEEGLSLDVVSG GEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINLGVGTFVADNFQELDKINNICKNKNIKQRVILRIIPGIEAHTHEYIR TGQIDSKFGFTLIDDGAIKAVKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEELDLGGGF GIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTLYSVGSIKEIPNIAKYIAVNGGMTDNI RPALYKSEYECVVCNKALDNLLEEVKVVGKCCESGDILIDNVKLPIVETDDLLAILNTGAYGYSMASNYNKALLPSVVFV NNDKTKLVCRRQSYENLIQNEV
Sequences:
>Translated_422_residues MNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYITSFDKEKNKVAYAGKAFLTKAMCNLIKEEGLSLDVVSG GEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINLGVGTFVADNFQELDKINNICKNKNIKQRVILRIIPGIEAHTHEYIR TGQIDSKFGFTLIDDGAIKAVKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEELDLGGGF GIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTLYSVGSIKEIPNIAKYIAVNGGMTDNI RPALYKSEYECVVCNKALDNLLEEVKVVGKCCESGDILIDNVKLPIVETDDLLAILNTGAYGYSMASNYNKALLPSVVFV NNDKTKLVCRRQSYENLIQNEV >Mature_422_residues MNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYITSFDKEKNKVAYAGKAFLTKAMCNLIKEEGLSLDVVSG GEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINLGVGTFVADNFQELDKINNICKNKNIKQRVILRIIPGIEAHTHEYIR TGQIDSKFGFTLIDDGAIKAVKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEELDLGGGF GIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTLYSVGSIKEIPNIAKYIAVNGGMTDNI RPALYKSEYECVVCNKALDNLLEEVKVVGKCCESGDILIDNVKLPIVETDDLLAILNTGAYGYSMASNYNKALLPSVVFV NNDKTKLVCRRQSYENLIQNEV
Specific function: Lysine biosynthesis; last step. [C]
COG id: COG0019
COG function: function code E; Diaminopimelate decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]
Homologues:
Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=30.8235294117647, Blast_Score=166, Evalue=4e-42, Organism=Drosophila melanogaster, GI24586472, Length=359, Percent_Identity=24.2339832869081, Blast_Score=70, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR009006 - InterPro: IPR002986 - InterPro: IPR022643 - InterPro: IPR022657 - InterPro: IPR022644 - InterPro: IPR022653 - InterPro: IPR000183 [H]
Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]
EC number: =4.1.1.20 [H]
Molecular weight: Translated: 47516; Mature: 47516
Theoretical pI: Translated: 5.28; Mature: 5.28
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.4 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 2.4 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYITSFDKEKNKVAYAGKAFL CCCCCCCEEEEECCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHH TKAMCNLIKEEGLSLDVVSGGEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINLGVGTFV HHHHHHHHHHCCCEEEEECCCCEEEHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHH ADNFQELDKINNICKNKNIKQRVILRIIPGIEAHTHEYIRTGQIDSKFGFTLIDDGAIKA HCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHH VKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEELDLGGGF HHHHHHHCCEEEEEEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCEEEHEEEECCCCE GIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTLYSVGSI EEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCEEEEECCCH KEIPNIAKYIAVNGGMTDNIRPALYKSEYECVVCNKALDNLLEEVKVVGKCCESGDILID HHCCHHHHHEEECCCCCCCCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEE NVKLPIVETDDLLAILNTGAYGYSMASNYNKALLPSVVFVNNDKTKLVCRRQSYENLIQN CEEEEEEECCCEEEEEECCCCCCHHHCCCCCHHCCEEEEEECCCEEEEEEHHHHHHHHHC EV CC >Mature Secondary Structure MNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYITSFDKEKNKVAYAGKAFL CCCCCCCEEEEECCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHH TKAMCNLIKEEGLSLDVVSGGEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINLGVGTFV HHHHHHHHHHCCCEEEEECCCCEEEHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHH ADNFQELDKINNICKNKNIKQRVILRIIPGIEAHTHEYIRTGQIDSKFGFTLIDDGAIKA HCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHH VKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEELDLGGGF HHHHHHHCCEEEEEEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCEEEHEEEECCCCE GIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTLYSVGSI EEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCEEEEECCCH KEIPNIAKYIAVNGGMTDNIRPALYKSEYECVVCNKALDNLLEEVKVVGKCCESGDILID HHCCHHHHHEEECCCCCCCCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEE NVKLPIVETDDLLAILNTGAYGYSMASNYNKALLPSVVFVNNDKTKLVCRRQSYENLIQN CEEEEEEECCCEEEEEECCCCCCHHHCCCCCHHCCEEEEEECCCEEEEEEHHHHHHHHHC EV CC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8215365 [H]