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The map label for this gene is guaA [H]

Identifier: 226950720

GI number: 226950720

Start: 3745855

End: 3747387

Strand: Reverse

Name: guaA [H]

Synonym: CLM_3728

Alternate gene names: 226950720

Gene position: 3747387-3745855 (Counterclockwise)

Preceding gene: 226950721

Following gene: 226950719

Centisome position: 90.18

GC content: 31.7

Gene sequence:

>1533_bases
ATGAATAAAGAATTAGTATTAGTAGTTGACTTTGGAGGTCAATATAATCAGTTAATAGCAAGACGTGTAAGAGAGAATAG
AGTGTATTGTGAAATAGTACCTTATACTACTTCTATAGAAGATATAAAAGAAAAAGCACCAAAGGGAATAATATTTACAG
GTGGTCCTAATAGTGTATATGGAGAAAATGCACCAAGAGTTCAAAAAGAATTATTTGATTTAGGTATTCCAGTCTTAGGT
ATATGTTATGGAGATCAACTTATGGCACATAGCTTAGAAGGTGAAGTAACAAGTCCTGAAAAAAGAGAATATGGTAAAAC
AGATGTAAATTTAGATAATAGTAGTTTATTGTTTAAGGATATGAAAGAGAAAGATCAATGCTGGATGAGTCATACAGATT
ATATTTCAAAGGTTCCAAAGGGATTTAAAATTATAGCAACAACAGATGAGTGCCCTTGTGCAGCTATGGAAAATGTAGAA
AAAAAATTATATGGAGTTCAATTTCATCCAGAGGTAGAGCATACTTTATTTGGCAAAAAAATGCTTAAGAACTTTTTGTT
TAACGTATGTAATTTAAAAGGTGATTGGAGTATGAGTTCTTTTGCAGAGCAGCAAATAAAAGCTATAAAGGAAAAAGTAG
GAGATAAAAAAGTAATATGCGCTTTATCAGGTGGAGTAGATTCATCAGTAGCAGCAGTAATTGTTCATAAAGCTATAGGG
AAACAATTAACTTGTATATTTGTTGATCATGGCTTACTTAGAAAAGATGAAGGAGATCAAGTAGAAAAAATATTTAAAGA
TCAATTTGATATGAATTTAATAAGAGTTAATGCTCAAGATAGATTTTTAGGAAAATTAAAAGGAGTTTCAGATCCAGAAA
GAAAAAGAAAAATAATTGGAGAAGAATTTATAAGAGTATTTGAAGAAGAAGCTAAAAAATTAGGTAATATAAGTTTCTTA
GTTCAAGGTACTATATATCCTGATATAGTAGAAAGTGGAACAAACACATCAGCTACTATAAAAAGCCACCACAATGTAGG
TGGGTTGCCAGAAGACATGGAATTTAAATTAATAGAACCTTTAAGAGAATTGTTTAAAGATGAAGTAAGAGCTGTTGGAG
AAGAATTAGGTATACCACATAAATTAGTATGGAGACAGCCATTCCCAGGACCAGGTTTAGCTATAAGAGTATTAGGTGAG
GTTACAGAGGAAAAATTAGCTATTACAAGGGAAGCAGATGCTATATTCAGAGAAGAGATAGCTAAAGCAGGCCTAGAAGA
AAAAATATGGCAATATTTTGCTTGCCTTCCAAACATACAATCAGTAGGAGTAATGGGAGATGAAAGAACATATTGCCATA
CAATAGCATTAAGAGCTGTTACATCTTCAGATGCGATGACTTCAGATTGGGCAAGAATACCTTATGAAGTATTAGATAAA
GTATCAAGAAGAATAGTAAATGAGGTTAAAGAAGTAAACAGAATCGTGTATGATGTAACTTCAAAACCACCAGCAACTAT
TGAATGGGAATAA

Upstream 100 bases:

>100_bases
AATTCAAACATCTTCAGGGATAAGAGAAAGTCATCCTCATGATATTTCAATAACAAAAGAAGCGCCAAATTATAGCGTTA
ATCAATAAAAGGAGGCACAT

Downstream 100 bases:

>100_bases
AATAAAGTTTAGTAAAGTTAATATTTAGATCATATAAAAAGTGCTTTCAATATTTACTTATATAAAAGTGAATTGAAAGC
ACTTTGTATTTTTTTGTAAT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENVE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGNISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE

Sequences:

>Translated_510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENVE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGNISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
>Mature_510_residues
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVYGENAPRVQKELFDLGIPVLG
ICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKDMKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENVE
KKLYGVQFHPEVEHTLFGKKMLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIGEEFIRVFEEEAKKLGNISFL
VQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGE
VTEEKLAITREADAIFREEIAKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=548, Percent_Identity=35.5839416058394, Blast_Score=302, Evalue=6e-82,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=50.4798464491363, Blast_Score=551, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI71992710, Length=569, Percent_Identity=36.3796133567663, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI71992717, Length=569, Percent_Identity=36.3796133567663, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=569, Percent_Identity=36.3796133567663, Blast_Score=311, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=52.7131782945737, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI281365319, Length=544, Percent_Identity=35.6617647058824, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57527; Mature: 57527

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVY
CCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCC
GENAPRVQKELFDLGIPVLGICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKD
CCCCHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHH
MKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENVEKKLYGVQFHPEVEHTLFGKK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCEECCCHHHHHHHHH
MLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHC
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIG
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHH
EEFIRVFEEEAKKLGNISFLVQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEP
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHH
LRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEVTEEKLAITREADAIFREEI
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
HHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHH
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECC
>Mature Secondary Structure
MNKELVLVVDFGGQYNQLIARRVRENRVYCEIVPYTTSIEDIKEKAPKGIIFTGGPNSVY
CCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCC
GENAPRVQKELFDLGIPVLGICYGDQLMAHSLEGEVTSPEKREYGKTDVNLDNSSLLFKD
CCCCHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHH
MKEKDQCWMSHTDYISKVPKGFKIIATTDECPCAAMENVEKKLYGVQFHPEVEHTLFGKK
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCEECCCHHHHHHHHH
MLKNFLFNVCNLKGDWSMSSFAEQQIKAIKEKVGDKKVICALSGGVDSSVAAVIVHKAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHC
KQLTCIFVDHGLLRKDEGDQVEKIFKDQFDMNLIRVNAQDRFLGKLKGVSDPERKRKIIG
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHH
EEFIRVFEEEAKKLGNISFLVQGTIYPDIVESGTNTSATIKSHHNVGGLPEDMEFKLIEP
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHH
LRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEVTEEKLAITREADAIFREEI
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AKAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVLDK
HHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHH
VSRRIVNEVKEVNRIVYDVTSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA