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The map label for this gene is guaB [H]

Identifier: 226950721

GI number: 226950721

Start: 3747400

End: 3748854

Strand: Reverse

Name: guaB [H]

Synonym: CLM_3729

Alternate gene names: 226950721

Gene position: 3748854-3747400 (Counterclockwise)

Preceding gene: 226950723

Following gene: 226950720

Centisome position: 90.22

GC content: 32.92

Gene sequence:

>1455_bases
ATGGCAAAAATAATAAAACAAGCATATACTTTTGATGACGTTCTTTTAGTTCCAAATAAATCAGAAGTTTTACCAAAGGA
AGTTAATTTAGGCACAAATTTAACTAAAAAAATAAAATTAAACATACCTCTTATGAGTGCCGGAATGGATACAGTTACGG
AGTCTAAAATGGCTATTGCTATGGCTAGAGAAGGCGGTATGGGAATAATACATAAAAATATGACTATAGCTGAGCAAGCT
AGTGAAGTTGATAAGGTAAAAAGACAAGAAAATGGAGTAATAGCAGATCCTTTTTATCTTGCACCAAATAATACTATACA
AGATGCATTAAATCTTATGAGTAGATACAGAATTTCTGGAGTACCTATAACTAAAGAAGGAAAATTAGTTGGAATAATAA
CTAATAGGGATATATTATTTGAAAATAATTATGAAAAGAAGATAGAAGAAGTTATGACTAAAGAGAATCTTATAACAGCA
CCAGAAAATACTACTATAGGGGAAGCAAAAGATATATTAAAATCACATAAAATAGAAAAATTACCTTTAGTCGATAAAGA
TAATAATTTACGTGGACTTATTACTATAAAAGATATAGAAAAAGTTAAAAAATTCCCTAATAGCGCTAAAGATTATAGGG
GAAGACTTTTATGTGGTGCAGCGGTTGGAGTTACAAAGGATATGATGGAAAGAGTAGACGCCTTAGTAAAAGCACAAGTA
GATATAATTACAGTAGATACCGCCCATGGACATTCTAAAGGAGTTATAGAAGGTGTAAAGAAAATAAAAGAAAAATATCC
AGATATTCAGATTATTGCAGGAAATGTTGCAACAGCTGAAGCAACTAGAGATTTAATAAATGCAGGAGCAGATTGTATAA
AGATCGGAATAGGACCTGGTTCTATATGTACAACTAGAGTAGTTGCAGGTGTAGGAGTGCCTCAACTTACAGCAGTTATG
GATTGTGTTGAAGAAGCAAATAAATATGGTATATCAGTAGTAGCTGATGGTGGAATTAAATATTCAGGAGATATAGTTAA
AGCACTAGCTGCTGGAGCTAAAGCTGTTATGATGGGTTCAATGTTTGCAGGATGTGCAGAAGCACCAGGAGAAACAGAAA
TATATCAAGGAAGAAGTTACAAAGTATATAGAGGGATGGGATCATTAGCTGCTATGGCTTGTGGTAGTAAGGATAGATAC
TTCCAAGAAGATAACAAAAAATTAGTTCCTGAAGGAGTAGAAGGAAGAGTACCATTTAAAGGACCAGTAATGGAAACTAT
ATATCAAATGCTAGGTGGCATTCGTTCAGGTATGGGATATTTAGGTTCTGCTACGTTGAATGATTTATATGAAAAGGCCA
CATTTGTAATTCAAACATCTTCAGGGATAAGAGAAAGTCATCCTCATGATATTTCAATAACAAAAGAAGCGCCAAATTAT
AGCGTTAATCAATAA

Upstream 100 bases:

>100_bases
TTATTAATAATGCTACAATAAAGGCCTATTAATTTTCACTTATAGTTTCAGTGGTAATTAATGTGTTTTTTTTTATAATT
TTATAGGAAGGATGATTTAA

Downstream 100 bases:

>100_bases
AAGGAGGCACATATGAATAAAGAATTAGTATTAGTAGTTGACTTTGGAGGTCAATATAATCAGTTAATAGCAAGACGTGT
AAGAGAGAATAGAGTGTATT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAKIIKQAYTFDDVLLVPNKSEVLPKEVNLGTNLTKKIKLNIPLMSAGMDTVTESKMAIAMAREGGMGIIHKNMTIAEQA
SEVDKVKRQENGVIADPFYLAPNNTIQDALNLMSRYRISGVPITKEGKLVGIITNRDILFENNYEKKIEEVMTKENLITA
PENTTIGEAKDILKSHKIEKLPLVDKDNNLRGLITIKDIEKVKKFPNSAKDYRGRLLCGAAVGVTKDMMERVDALVKAQV
DIITVDTAHGHSKGVIEGVKKIKEKYPDIQIIAGNVATAEATRDLINAGADCIKIGIGPGSICTTRVVAGVGVPQLTAVM
DCVEEANKYGISVVADGGIKYSGDIVKALAAGAKAVMMGSMFAGCAEAPGETEIYQGRSYKVYRGMGSLAAMACGSKDRY
FQEDNKKLVPEGVEGRVPFKGPVMETIYQMLGGIRSGMGYLGSATLNDLYEKATFVIQTSSGIRESHPHDISITKEAPNY
SVNQ

Sequences:

>Translated_484_residues
MAKIIKQAYTFDDVLLVPNKSEVLPKEVNLGTNLTKKIKLNIPLMSAGMDTVTESKMAIAMAREGGMGIIHKNMTIAEQA
SEVDKVKRQENGVIADPFYLAPNNTIQDALNLMSRYRISGVPITKEGKLVGIITNRDILFENNYEKKIEEVMTKENLITA
PENTTIGEAKDILKSHKIEKLPLVDKDNNLRGLITIKDIEKVKKFPNSAKDYRGRLLCGAAVGVTKDMMERVDALVKAQV
DIITVDTAHGHSKGVIEGVKKIKEKYPDIQIIAGNVATAEATRDLINAGADCIKIGIGPGSICTTRVVAGVGVPQLTAVM
DCVEEANKYGISVVADGGIKYSGDIVKALAAGAKAVMMGSMFAGCAEAPGETEIYQGRSYKVYRGMGSLAAMACGSKDRY
FQEDNKKLVPEGVEGRVPFKGPVMETIYQMLGGIRSGMGYLGSATLNDLYEKATFVIQTSSGIRESHPHDISITKEAPNY
SVNQ
>Mature_483_residues
AKIIKQAYTFDDVLLVPNKSEVLPKEVNLGTNLTKKIKLNIPLMSAGMDTVTESKMAIAMAREGGMGIIHKNMTIAEQAS
EVDKVKRQENGVIADPFYLAPNNTIQDALNLMSRYRISGVPITKEGKLVGIITNRDILFENNYEKKIEEVMTKENLITAP
ENTTIGEAKDILKSHKIEKLPLVDKDNNLRGLITIKDIEKVKKFPNSAKDYRGRLLCGAAVGVTKDMMERVDALVKAQVD
IITVDTAHGHSKGVIEGVKKIKEKYPDIQIIAGNVATAEATRDLINAGADCIKIGIGPGSICTTRVVAGVGVPQLTAVMD
CVEEANKYGISVVADGGIKYSGDIVKALAAGAKAVMMGSMFAGCAEAPGETEIYQGRSYKVYRGMGSLAAMACGSKDRYF
QEDNKKLVPEGVEGRVPFKGPVMETIYQMLGGIRSGMGYLGSATLNDLYEKATFVIQTSSGIRESHPHDISITKEAPNYS
VNQ

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=42.5, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=42.9166666666667, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=42.9166666666667, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=42.9166666666667, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=42.9166666666667, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI217035152, Length=477, Percent_Identity=42.9769392033543, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=42.0833333333333, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=40, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI50541954, Length=239, Percent_Identity=42.2594142259414, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI50541952, Length=239, Percent_Identity=42.2594142259414, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI50541948, Length=239, Percent_Identity=42.2594142259414, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI50541956, Length=239, Percent_Identity=42.2594142259414, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI156104880, Length=236, Percent_Identity=41.1016949152542, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=54.8979591836735, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=217, Percent_Identity=39.63133640553, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994385, Length=474, Percent_Identity=39.0295358649789, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=40.7582938388626, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17560440, Length=277, Percent_Identity=36.4620938628159, Blast_Score=174, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=40.6570841889117, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=39.8357289527721, Blast_Score=336, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=478, Percent_Identity=41.4225941422594, Blast_Score=332, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=385, Percent_Identity=39.4805194805195, Blast_Score=262, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=36.6197183098592, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=40.5405405405405, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=40.5405405405405, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=41.2300683371298, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52383; Mature: 52252

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIKQAYTFDDVLLVPNKSEVLPKEVNLGTNLTKKIKLNIPLMSAGMDTVTESKMAIA
CHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCEEECCCCHHHHHHHEEE
MAREGGMGIIHKNMTIAEQASEVDKVKRQENGVIADPFYLAPNNTIQDALNLMSRYRISG
EECCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEECCEEECCCCHHHHHHHHHHHHCCCC
VPITKEGKLVGIITNRDILFENNYEKKIEEVMTKENLITAPENTTIGEAKDILKSHKIEK
CCCCCCCCEEEEEECCEEEEECCHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCCC
LPLVDKDNNLRGLITIKDIEKVKKFPNSAKDYRGRLLCGAAVGVTKDMMERVDALVKAQV
CCCCCCCCCCEEEEEEHHHHHHHHCCCCCHHHCCEEEEEHHHHHHHHHHHHHHHHHHCEE
DIITVDTAHGHSKGVIEGVKKIKEKYPDIQIIAGNVATAEATRDLINAGADCIKIGIGPG
EEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCC
SICTTRVVAGVGVPQLTAVMDCVEEANKYGISVVADGGIKYSGDIVKALAAGAKAVMMGS
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHHCHHHHHHHH
MFAGCAEAPGETEIYQGRSYKVYRGMGSLAAMACGSKDRYFQEDNKKLVPEGVEGRVPFK
HHHHHCCCCCCCEEECCCCEEEECCCCHHHHHHCCCCCCCHHCCCCEECCCCCCCCCCCC
GPVMETIYQMLGGIRSGMGYLGSATLNDLYEKATFVIQTSSGIRESHPHDISITKEAPNY
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEEEECCCCCCCCCCCEEEECCCCCC
SVNQ
CCCC
>Mature Secondary Structure 
AKIIKQAYTFDDVLLVPNKSEVLPKEVNLGTNLTKKIKLNIPLMSAGMDTVTESKMAIA
HHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCEEECCCCHHHHHHHEEE
MAREGGMGIIHKNMTIAEQASEVDKVKRQENGVIADPFYLAPNNTIQDALNLMSRYRISG
EECCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEECCEEECCCCHHHHHHHHHHHHCCCC
VPITKEGKLVGIITNRDILFENNYEKKIEEVMTKENLITAPENTTIGEAKDILKSHKIEK
CCCCCCCCEEEEEECCEEEEECCHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCCC
LPLVDKDNNLRGLITIKDIEKVKKFPNSAKDYRGRLLCGAAVGVTKDMMERVDALVKAQV
CCCCCCCCCCEEEEEEHHHHHHHHCCCCCHHHCCEEEEEHHHHHHHHHHHHHHHHHHCEE
DIITVDTAHGHSKGVIEGVKKIKEKYPDIQIIAGNVATAEATRDLINAGADCIKIGIGPG
EEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCC
SICTTRVVAGVGVPQLTAVMDCVEEANKYGISVVADGGIKYSGDIVKALAAGAKAVMMGS
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHHCHHHHHHHH
MFAGCAEAPGETEIYQGRSYKVYRGMGSLAAMACGSKDRYFQEDNKKLVPEGVEGRVPFK
HHHHHCCCCCCCEEECCCCEEEECCCCHHHHHHCCCCCCCHHCCCCEECCCCCCCCCCCC
GPVMETIYQMLGGIRSGMGYLGSATLNDLYEKATFVIQTSSGIRESHPHDISITKEAPNY
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEEEECCCCCCCCCCCEEEECCCCCC
SVNQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]