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The map label for this gene is pyrE [H]

Identifier: 226950663

GI number: 226950663

Start: 3687456

End: 3688031

Strand: Reverse

Name: pyrE [H]

Synonym: CLM_3647

Alternate gene names: 226950663

Gene position: 3688031-3687456 (Counterclockwise)

Preceding gene: 226950664

Following gene: 226950662

Centisome position: 88.76

GC content: 29.69

Gene sequence:

>576_bases
ATGAGTAATATAAATGTTATAGATATATTAAAAGAATCAGATGCGTTATTAGAAGGACATTTCTTATTATCATCAGGAAG
ACATAGTAATAGATATTGTCAATGTGCAAAACTACTCCAATGCCCACAAAAAGCAGAAAAAGTTATTAGTGTAATAGCAG
AAAAGCTTAAAGAAGTAGATTTTAATATAATAGTAGGACCAGCTATGGGAGGGGTAATAGTATCCTATGAATTAGCAAGA
CAAACTAATAAACCTGGCATATTTGCAGAAAGAAAAGAAGAGGTTATGTGCATAAGAAGGGGATTTGAAATAAAAAAAGG
AGATAAAGTTATAATATCAGAAGATGTAGTAACTACAGGAAAATCTTCTTTAGAAGTAGCTAAAGTTATAGAAGAAATGG
GTGGAGAAGTAGTAGGTATAGCATGTATAGTTGATAGAAGAGCAGAAGATATAAAAACAAACTATCCAATATATAGTGCT
TGTAAATTAGAAATAGAAACTTATGAAAAAGATAACTGTGAGTTATGCAAAAAAAACATACCTTTTGTAAAACCAGGTAG
CAGAGAACAAAAATAA

Upstream 100 bases:

>100_bases
GGACTTAGAAAATTATATGAAAAAACAAGGTATTAAAAATTTAGAAGAAATAAGGGGAATTATTTAAAATAAATTTTGAG
AATATAAGGAGAAGATATAA

Downstream 100 bases:

>100_bases
ATTTTAAAATAAGAGTTGTCTCAAAATAGATTTAATTTTGGGACATTTTTTTAGTTTTAACAAATATTAAACAAAAACTT
AATTTTACTTTAATAATTAT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELAR
QTNKPGIFAERKEEVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSA
CKLEIETYEKDNCELCKKNIPFVKPGSREQK

Sequences:

>Translated_191_residues
MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELAR
QTNKPGIFAERKEEVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSA
CKLEIETYEKDNCELCKKNIPFVKPGSREQK
>Mature_190_residues
SNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELARQ
TNKPGIFAERKEEVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSAC
KLEIETYEKDNCELCKKNIPFVKPGSREQK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 21312; Mature: 21181

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVD
CCCCCEEEEECCCCCHHCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
FNIIVGPAMGGVIVSYELARQTNKPGIFAERKEEVMCIRRGFEIKKGDKVIISEDVVTTG
CEEEECCCCCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
KSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSACKLEIETYEKDNCELCKKNI
CHHHHHHHHHHHHCCCEEEEEEEECCCHHHHCCCCCEEEEEEEEEEECCCCCHHHHHCCC
PFVKPGSREQK
CCCCCCCCCCC
>Mature Secondary Structure 
SNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVD
CCCCEEEEECCCCCHHCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
FNIIVGPAMGGVIVSYELARQTNKPGIFAERKEEVMCIRRGFEIKKGDKVIISEDVVTTG
CEEEECCCCCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
KSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSACKLEIETYEKDNCELCKKNI
CHHHHHHHHHHHHCCCEEEEEEEECCCHHHHCCCCCEEEEEEEEEEECCCCCHHHHHCCC
PFVKPGSREQK
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA