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The map label for this gene is proC [H]

Identifier: 226950610

GI number: 226950610

Start: 3629531

End: 3630337

Strand: Reverse

Name: proC [H]

Synonym: CLM_3594

Alternate gene names: 226950610

Gene position: 3630337-3629531 (Counterclockwise)

Preceding gene: 226950611

Following gene: 226950609

Centisome position: 87.37

GC content: 32.84

Gene sequence:

>807_bases
ATGAATAAAGTAATTGGATTTATTGGTGCTGGAAATATGGGACAAGCAATGGTTGGGGGAATAGTTAATTCAAAATTAGT
TGCCCCAGAAAATATTATATTATCAGATTTGAATGAAAAGGCATTAGAAGCTGCTAAAGAAAGATTTGGGGTTAGAGTAA
CAACAAATAGCAATAAATTAGCTAAAGAAGTAGATATATTAGTTTTATCTGTAAAACCAAATTTATATCCAATAGTTATA
AAAGGTATAAAAGATAGTGTTAAAAAAGAAGTTATAGTAGTTACTATCGCAGCTGGTAAAGCATTAGAAGATACTGAAAC
TATGTTTGGAAAAAGAATAAAAATAGTTAGAGTAATGCCTAATACTCCTGCATTAGTTGGAGAAGGTATGGCTGCTGTAT
GTCCTAACGATTTGGTTTCTAAAGAGGAAGCTGAAGAAGTCATAAGTATCTTTGAAAGCTTTGGAAAAGCAGAAATAGTG
GAAGAGAAATTGATGGATGCAGTAACTGCAGTAAGTGGTTCATCTCCGGCTTATGTGTATATATTTATAGAAGCTATGGC
AGATGCAGCTGTGTTAGAAGGTATGCCAAGAGATAAGGCTTATAAATTTGCATCACAAGCTGTATTAGGATCAGCAAAAA
TGGTTCTAGAAACAGGAATGCATCCAGGTGCATTAAAAGATATGGTTTGTTCACCAGGAGGAACTACAATTGAGGCAGTA
GCAACTCTTGAAAAAAATGGTTTTAGAAATGCAATTATAAAAGCTATGAGAGATTGTGCAATAAAATCTAAAGAAATGTC
TAAATAA

Upstream 100 bases:

>100_bases
ATATATTATTGTAAAGAAAAATAAAAGCTAGGAGAAGGAACTAAGATTTATAATTTAAGTCTTTCTCCTAGTAACAAATT
TTTATTAGGAGGAAAGCTAC

Downstream 100 bases:

>100_bases
TACAGTTAACATTTCTTCGTTATCCTATCTTTTAAAGATAGGATAACGAAAAAATATAAAACAAATTAACAAGATATAGA
AACAATAATCAGAATATTGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPENIILSDLNEKALEAAKERFGVRVTTNSNKLAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTAVSGSSPAYVYIFIEAMADAAVLEGMPRDKAYKFASQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIKAMRDCAIKSKEMSK

Sequences:

>Translated_268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPENIILSDLNEKALEAAKERFGVRVTTNSNKLAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTAVSGSSPAYVYIFIEAMADAAVLEGMPRDKAYKFASQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIKAMRDCAIKSKEMSK
>Mature_268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPENIILSDLNEKALEAAKERFGVRVTTNSNKLAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTAVSGSSPAYVYIFIEAMADAAVLEGMPRDKAYKFASQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIKAMRDCAIKSKEMSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=37.0786516853933, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=36.0902255639098, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=36.0902255639098, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=33.4586466165414, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=53.3582089552239, Blast_Score=284, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=37.7862595419847, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17540664, Length=278, Percent_Identity=35.9712230215827, Blast_Score=163, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320861, Length=279, Percent_Identity=32.258064516129, Blast_Score=125, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=37.1212121212121, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=37.8571428571429, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=43.1952662721894, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28541; Mature: 28541

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPENIILSDLNEKALEAAKERFGVRVTTNSNKL
CCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHCCEEEEECCCHH
AKEVDILVLSVKPNLYPIVIKGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMP
HHEEEEEEEEECCCEEEEEEECCHHHCCCEEEEEEEECCCCCHHHHHHHCCEEEEEEECC
NTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIVEEKLMDAVTAVSGSSPAYVY
CCCCHHCCCCHHCCCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEE
IFIEAMADAAVLEGMPRDKAYKFASQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
EEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEKNGFRNAIIKAMRDCAIKSKEMSK
HHHHHCCHHHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure
MNKVIGFIGAGNMGQAMVGGIVNSKLVAPENIILSDLNEKALEAAKERFGVRVTTNSNKL
CCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHCCEEEEECCCHH
AKEVDILVLSVKPNLYPIVIKGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMP
HHEEEEEEEEECCCEEEEEEECCHHHCCCEEEEEEEECCCCCHHHHHHHCCEEEEEEECC
NTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIVEEKLMDAVTAVSGSSPAYVY
CCCCHHCCCCHHCCCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEE
IFIEAMADAAVLEGMPRDKAYKFASQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
EEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEKNGFRNAIIKAMRDCAIKSKEMSK
HHHHHCCHHHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]