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The map label for this gene is iscS [H]

Identifier: 226949923

GI number: 226949923

Start: 2879826

End: 2881019

Strand: Reverse

Name: iscS [H]

Synonym: CLM_2875

Alternate gene names: 226949923

Gene position: 2881019-2879826 (Counterclockwise)

Preceding gene: 226949924

Following gene: 226949922

Centisome position: 69.33

GC content: 31.99

Gene sequence:

>1194_bases
ATGAATAAACAAGTTTATATGGATTATTCAGCTACTACTTATACAAAACCAGAGGTATTAGAAGAAATGCTTCCATTTTT
TACTGAAAATTTTGGAAATCCATCTTCTTTATATTCTTTCTCAGATAAAACTAAAAAAGCTGTAAATCTAGCAAGAGAAA
GAGTATCAAAGGCATTAAATGCAGAAAAAAATGAGATATTCTTTACAAGTGGTGGCTCAGAAGCAGATAACTGGGCCCTA
AAAGGAATAGCTTATGCTAATAAAAAGAAGGGAAATCATATAATCACCACTAAGATAGAACATCATGCTATATTACATAC
GGCACAATTCTTAGAAAAAGAAGGCTTCAAAGTAACTTATCTTCCAGTAGATGAGGAGGGCTTTGTAAGTGTAGAGGATA
TAAAAAATGCTATAACAGATGAAACTATCCTAGTTTCTGTAATGTTTGCTAACAACGAAATAGGAACTATAGAACCAATA
AAAGAAATAGGGGAATTATGTAAGGAAAAAAATATTTATTTCCATACAGATGCAGTTCAAGCTATAGGTCATGTAGATAT
AGATGTAAAAGATATGAATATAGATTTGCTATCTATGTCTGCTCATAAATTTTATGGACCTAAAGGAGTAGGTGCTCTAT
ATATAAAAAATGGAGTTAAAATACAAAACTTAATTCATGGTGGAGGACAAGAAAGAGGTAAAAGGGCTAGCACAGAAGAC
ACAGCTGGAATAGTAGGGCTTGGTAAGGCCATAGAATTAGCTATGGAAAATATGCCTGAAGAAAATGAAAAACTATCTAA
TTTAAGAGGAAGGTTAATAAGAGGAATAGAAGCAAGGATACCTGAAGTAAAATTAAATGGTCCTAAAGATATGAGTAGAA
GATTACCTAATAATGTTAATTTTAGTTTTATAGGTATTGAGGGGGAAACTTTATTATTGGATTTGGATATGAATGGCATA
TTTGGATCTACAGGAAGTGCTTGTGCTTCAGCATCTTTAGATCCATCCCATGTGCTTTTATCTATAGGACTACCACATGA
AACAGCTCATGGTTCTTTGAGATTAAGCTTAGGAGCTAAGAACACAGAAGAAGATATAGATTATGTATTAGAAGTACTTC
CTAAAATAATAAAACAAAGAAGAGAAATGTCACCACTTTGGGAAGATTATATGAAAAACAAGGAGGAAAAATAA

Upstream 100 bases:

>100_bases
ATAAAGGAAAGTCTAGATAATATAATGGAATCAACTACCTTACAAGATATGGTAGAAGACTATAAGAAAATAAATTCACC
AATTAAAAGGAGTGAAAATA

Downstream 100 bases:

>100_bases
TATGTATACAGAAAAGGTAATGGATCATTTTAGAAATCCTAGAAATGTAGGGGAAATAGAAGATGCTAATGGTATAGGTG
AAGTAGGAAACGCTAAATGT

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALNAEKNEIFFTSGGSEADNWAL
KGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTYLPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPI
KEIGELCKEKNIYFHTDAVQAIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
TAGIVGLGKAIELAMENMPEENEKLSNLRGRLIRGIEARIPEVKLNGPKDMSRRLPNNVNFSFIGIEGETLLLDLDMNGI
FGSTGSACASASLDPSHVLLSIGLPHETAHGSLRLSLGAKNTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK

Sequences:

>Translated_397_residues
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALNAEKNEIFFTSGGSEADNWAL
KGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTYLPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPI
KEIGELCKEKNIYFHTDAVQAIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
TAGIVGLGKAIELAMENMPEENEKLSNLRGRLIRGIEARIPEVKLNGPKDMSRRLPNNVNFSFIGIEGETLLLDLDMNGI
FGSTGSACASASLDPSHVLLSIGLPHETAHGSLRLSLGAKNTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK
>Mature_397_residues
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALNAEKNEIFFTSGGSEADNWAL
KGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTYLPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPI
KEIGELCKEKNIYFHTDAVQAIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
TAGIVGLGKAIELAMENMPEENEKLSNLRGRLIRGIEARIPEVKLNGPKDMSRRLPNNVNFSFIGIEGETLLLDLDMNGI
FGSTGSACASASLDPSHVLLSIGLPHETAHGSLRLSLGAKNTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=389, Percent_Identity=45.5012853470437, Blast_Score=360, Evalue=1e-100,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=37.1980676328502, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI48994898, Length=395, Percent_Identity=47.0886075949367, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=25.5050505050505, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789175, Length=394, Percent_Identity=25.3807106598985, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=390, Percent_Identity=46.1538461538462, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17533177, Length=334, Percent_Identity=31.7365269461078, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319831, Length=390, Percent_Identity=45.8974358974359, Blast_Score=346, Evalue=4e-96,
Organism=Drosophila melanogaster, GI20129463, Length=389, Percent_Identity=44.987146529563, Blast_Score=340, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44109; Mature: 44109

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALN
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHC
AEKNEIFFTSGGSEADNWALKGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTY
CCCCEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHCCCEEEE
LPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPIKEIGELCKEKNIYFHTDAVQ
EECCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEHHHH
AIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
HHCCCEEEEEECCEEEEEECHHHCCCCCCCCEEEEECCCEEEHHHCCCCHHCCCCCCCCC
TAGIVGLGKAIELAMENMPEENEKLSNLRGRLIRGIEARIPEVKLNGPKDMSRRLPNNVN
CCCEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCC
FSFIGIEGETLLLDLDMNGIFGSTGSACASASLDPSHVLLSIGLPHETAHGSLRLSLGAK
EEEEEECCCEEEEEECCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCC
NTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALN
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHC
AEKNEIFFTSGGSEADNWALKGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTY
CCCCEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHCCCEEEE
LPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPIKEIGELCKEKNIYFHTDAVQ
EECCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEHHHH
AIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
HHCCCEEEEEECCEEEEEECHHHCCCCCCCCEEEEECCCEEEHHHCCCCHHCCCCCCCCC
TAGIVGLGKAIELAMENMPEENEKLSNLRGRLIRGIEARIPEVKLNGPKDMSRRLPNNVN
CCCEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCC
FSFIGIEGETLLLDLDMNGIFGSTGSACASASLDPSHVLLSIGLPHETAHGSLRLSLGAK
EEEEEECCCEEEEEECCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCC
NTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA