Click here to switch to the map view.

The map label for this gene is cymR [H]

Identifier: 226949924

GI number: 226949924

Start: 2881012

End: 2881458

Strand: Reverse

Name: cymR [H]

Synonym: CLM_2876

Alternate gene names: 226949924

Gene position: 2881458-2881012 (Counterclockwise)

Preceding gene: 226949925

Following gene: 226949923

Centisome position: 69.34

GC content: 33.56

Gene sequence:

>447_bases
ATGAAGTTGTCAACTAAGGGTAGGTATGGAGTAAAGGCTATGGTAGATTTGGCAATTAACTACGGTGGGCAACCAGTTTC
TATAAAAAATATTTCAGAAAGGCAACATATATCTGAGTATTATTTAGAACAATTATTTTCCCCACTTAGAAAGGCTAAAC
TTATAAAAAGCATAAGGGGAGCTCAAGGGGGCTATATTTTAAATAGGCATCCTAAGGACATAACTGTGGCAGATATTATG
GAGGTTTTAGAAGGCCCTATAGAAATATCTAGTTGTTTAGAGGGAGAGGATAGTTGTAGTAATATGGATTGTTGTGCAAC
TAGACTTTTGTGGGCAAAGATAAAGGAAAGTCTAGATAATATAATGGAATCAACTACCTTACAAGATATGGTAGAAGACT
ATAAGAAAATAAATTCACCAATTAAAAGGAGTGAAAATAATGAATAA

Upstream 100 bases:

>100_bases
TTTTGACAAAATTTATTAATATTGTTGACAGGTTTAGTCTGATTTGCTATTATAAAAATAAATCATAGTAAAGTGGTCAA
CATTAAAAGGATGTGATTAA

Downstream 100 bases:

>100_bases
ACAAGTTTATATGGATTATTCAGCTACTACTTATACAAAACCAGAGGTATTAGAAGAAATGCTTCCATTTTTTACTGAAA
ATTTTGGAAATCCATCTTCT

Product: rrF2 family protein

Products: NA

Alternate protein names: Cysteine metabolism repressor [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKLSTKGRYGVKAMVDLAINYGGQPVSIKNISERQHISEYYLEQLFSPLRKAKLIKSIRGAQGGYILNRHPKDITVADIM
EVLEGPIEISSCLEGEDSCSNMDCCATRLLWAKIKESLDNIMESTTLQDMVEDYKKINSPIKRSENNE

Sequences:

>Translated_148_residues
MKLSTKGRYGVKAMVDLAINYGGQPVSIKNISERQHISEYYLEQLFSPLRKAKLIKSIRGAQGGYILNRHPKDITVADIM
EVLEGPIEISSCLEGEDSCSNMDCCATRLLWAKIKESLDNIMESTTLQDMVEDYKKINSPIKRSENNE
>Mature_148_residues
MKLSTKGRYGVKAMVDLAINYGGQPVSIKNISERQHISEYYLEQLFSPLRKAKLIKSIRGAQGGYILNRHPKDITVADIM
EVLEGPIEISSCLEGEDSCSNMDCCATRLLWAKIKESLDNIMESTTLQDMVEDYKKINSPIKRSENNE

Specific function: Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulate

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=138, Percent_Identity=36.231884057971, Blast_Score=98, Evalue=2e-22,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000944 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 16701; Mature: 16701

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSTKGRYGVKAMVDLAINYGGQPVSIKNISERQHISEYYLEQLFSPLRKAKLIKSIRG
CCCCCCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AQGGYILNRHPKDITVADIMEVLEGPIEISSCLEGEDSCSNMDCCATRLLWAKIKESLDN
CCCCEEECCCCCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
IMESTTLQDMVEDYKKINSPIKRSENNE
HHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLSTKGRYGVKAMVDLAINYGGQPVSIKNISERQHISEYYLEQLFSPLRKAKLIKSIRG
CCCCCCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AQGGYILNRHPKDITVADIMEVLEGPIEISSCLEGEDSCSNMDCCATRLLWAKIKESLDN
CCCCEEECCCCCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
IMESTTLQDMVEDYKKINSPIKRSENNE
HHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]